Pathological findings in human autoimmune lymphoproliferative syndrome

American Journal of Pathology

Volumn 153, Issue 5, 1998, Pages 1541-1550

  Lim, Megan S ^a   Straus, Stephen E ^b   Dale, Janet K ^b   Fleisher, Thomas A ^c   Stetler Stevenson, Maryalice ^a   Strober, Warren ^b   Sneller, Michael C ^b   Puck, Jennifer M ^d   Lenardo, Michael J ^b   Elenitoba Johnson, Kojo S J ^a   Lin, Albert Y ^a   Raffeld, Mark ^a   Jaffe, Elaine S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; DISEASE ASSOCIATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; HISTOPATHOLOGY; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPH NODE; LYMPHOPROLIFERATIVE DISEASE; PATIENT SELECTION; PLASMACYTOSIS; PRIORITY JOURNAL;

EID: 0031737954     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65742-2     Document Type: Article

References (34)

1. Sneller MC, Straus SE, Jaffe ES, Jaffe JS, Fieisher TA, Stetler-Stevenson M, Strober W: A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease. J Clin Invest 1992, 90:334-341
2. Watanabe-Fukunaga R, Brannan PE, Copeland NG, Jenkins N, Nagata S: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992, 356:314-317
3. Takahashi T, Tanaka M, Rannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994, 76:969-977
4. Lynch DH, Watson ML, Alderson MR, Baum PR, Miller RE, Tough T, Gibson M, Davis-Smith T, Smith CA, Hunter K, Bhat D, Din W, Goodwin RG, Seldin MF: The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1994, 1:131-140
5. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middleton LA, Lin AY, Strober W, Lenardo MJ, Puck JM: Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 1995, 81:935-946
6. Drappa J, Vaishnaw A, Sullivan KE, Chu J, Elkon KB: Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 1996, 335:1643-1649
7. Rieux-Laucat F, Le Diest F, Hivroz C, Roberts IA, Debatin KM, Fischer A, de Villartay JP: Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 1995, 268:1347-1349
8. Le Deist F, Emile J-F, Rieux-Laucat F, Benkerrou M, Roberts I, Brousse N, Fischer A: Clinical, immunological and pathological consequences of fas-deficient conditions. Lancet 1996, 348:719-723
9. Canale VC, Smith, CH: Chronic lymphadenopathy simulating malignant lymphoma. J Pediatr 1967, 70:891-899
10. Rao LM, Shahidi NT, Opitz JM: Hereditary splenomegaly with hypersplenism. Clin Genet 1974, 5:379-386
11. Gillette-Ferguson I, Sidman CL: A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. Eur J lmmunol 1994, 24:1181-1185
12. Adachi M, Suematsu S, Kondo T, Ogasawara J, Tanaka T, Yoshida N, Nagata S: Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nature Genet 1995, 11:294-300
13. Adachi M, Suematsu S, Suda T, Watanabe D, Fukuyama H, Ogasawara J, Tanaka T, Yoshida N, Shigekazu N: Enhanced and accelerated lymphoproliferation in Fas-null mice. Biochem 1996, 93:2131-2136
14. Infante AJ, Britton HA, DeNapoli T, Middelton LA, Lenardo MJ, Jackson CE, Wang J, Fleisher T, Straus SE, Puck JM: The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome (ALPS) due to a fas mutation that impairs lymphocyte apoptosis. J Pediatr (in press)
15. Sneller MC, Wang J, Dale JK, Strober W, Middleton LA, Choi Y, Fieisher TA, Lim MS, Jaffe ES, Puck JM, Lenardo MJ, Straus SE: Clinical, immunologic and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. Blood 1997, 89:1341-1348
16. Elenitoba-Johnson KSJ, Kumar S, Lim MS, Kingma DW, Raffeld M, Jaffe E: Marginal zone B-cell lymphoma with monocytoid B-cell lymphocytes in pediatric patients without immunodeficiency: a report of two cases. Am J Clin Pathol 1997, 107:92-98
17. McCarthy KP, Sloane JP, Kabarowski JH, Matutes E, Wiedermann LM: A simplified method of detection of clonal rearrangement of the TCR-γ chain gene. Diagn Mol Pathol 1992, 1:173-179
18. Natkunam Y, Elenitoba-Johnson KS, Kingma DW, Kamel O: Epstein-Barr virus strain type and latent membrane protein-1 gene deletions in lymphoma in patients with rheumatic disease. Arthritis Rheum 1997, 40:1152-1156
19. Dianzani U, Bragardo M, DiFranco D, Alliaudi C, Scagni P, Buonfiglio D, Redoglia V, Bonissoni S, Correra A, Dianzani I, Ramenghi U: Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation. Blood 1997, 89:2871-2879
20. Tedder TF, Cooper MD, Clement LT: Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. J Immunol 1985, 134:2989-2994
21. Chittal SM, Brousset P, Voigt J-J, Delsol G: Large B-cell lymphoma rich in T-cells and simulating Hodgkin's disease. Histopathology 1992, 19:211-220
22. Delabie, J, Vandenberghe E, Kennes C, Verhoef G, Foschini MP, Stul M, Cassiman JJ, De Wolf-Peeters C: Histiocyte-rich B-cell lymphoma: a distinct clinicopathologic entity possibly related to lymphocyte predominant Hodgkin's disease, paragranuloma subtype. Am J Surg Pathol 1992, 16:32-48
23. Wu J, Wilson J, He J, Xiang L, Schur PH, Mountz JD: Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. J Clin Invest 1996, 98:1107-1113
24. - intermediate stage. Eur J Immunol 1986, 16:653-658
25. -) lymphocytes bearing T cell receptor α and β chains in normal human skin. Proc Natl Acad Sci USA 1989, 86:5059-5063
26. + T lymphocytes that express neither CD4 nor CD8 antigens. J Exp Med 1986, 164: 339-344
27. Lenkei R, Andersson B: High correlations of anti-CMV titers with lymphocyte activation status and CD57 antibody-binding capacity as estimated with three-color, quantitative flow cytometry in blood donors. Clin Immunol 1995, 77:131-138
28. + T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 1989, 143:103-112
29. Wirt DP, Rooks EG, Vaidya S, Klimpel GR, Waldmann TA, Goldblum RM: Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease. N Engl J Med 1989, 321: 370-374
30. Fuss IJ, Strober W, Dale JK, Fritz S, Pearlstein GR, Puck JM, Lenardo MJ, Straus SE: Characteristic T helper 2 T cell cytokine abnormalities in autoimmune lymphoproliferative syndrome, a syndrome marked by defective apoptosis and humoral autoimmunity. J Immunol 1997, 158:1912-1918
31. Giese T, Davidson WF: Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production. J Immunol 1994, 152:2000-2010
32. + double-negative T cells as the predominant populations in enlarged lymph nodes. J Immunol 1995, 154:4986-4995
33. Warren HS, Skipsey SM: Loss of activation-induced CD45RO with maintenance of CD45RA expressing prolonged culture of T cells and NK cells. Immunology 1991, 74:78
34. Pritsch O, Maloum K, Dighiero G: Basic biology of autoimmune phenomena in chronic lymphocytic leukemia. Semin Oncol 1998, 25:34-41