Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains

Development

Volumn 129, Issue 6, 2002, Pages 1327-1338

  Takahashi, Masanori ^a   Osumi, Noriko ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Hindbrain; Homeodomain proteins; Interneurones; Neuronal specification; Pax6; Progenitor domains; Small eye rat; Somatic motoneurones

Indexed keywords

CELL MARKER; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR PAX6;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPORATION; EMBRYO; EMBRYO CULTURE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HOMOZYGOSITY; INTERNEURON; MALE; MOTONEURON; MUTANT; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RAT; RHOMBENCEPHALON; SPINAL CORD; STEM CELL; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PAIRED BOX TRANSCRIPTION FACTORS; RATS; REPRESSOR PROTEINS; RHOMBENCEPHALON; TRANS-ACTIVATORS;

ANIMALIA; MAMMALIA;

EID: 0036333291     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
2. A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner
3. Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system
4. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
5. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
6. + interneurons that require PAX6 for their development
7. Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6
8. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
9. Differential progenitor dispersal and the spatial origin of early neurons can explain the predominance of single-phenotype clones in the chick hindbrain
10. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
11. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
12. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
13. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
14. The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ
15. Progenitor dispersal and the origin of early neuronal phenotypes in the chick embryo spinal cord
16. Pax6: Mastering eye morphogenesis and eye evolution
17. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
18. Pax6 controls radial glia differentiation in the cerebral cortex
19. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord
20. Pax in development
21. Sliberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
22. Molecular genetics of the Pax gene family
23. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
24. Fate mapping of the mouse prosencephalic neural plate
25. Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development
26. Demarcation of early mammalian cortical development by differential expression of fringe genes
27. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
28. Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells
29. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
30. The specification of dorsal cell fates in the vertebrate central nervous system
31. A role for the roof plate and its resident TGF-β related proteins in neuronal patterning in the dorsal spinal cord
32. Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer
33. Expression pattern of a murine homeobox gene, Dbx, displays extreme spatial restriction in embryonic forebrain and spinal cord
34. Mouse homeobox gene Dbx: Sequence, gene structure and expression pattern during mid-gestation
35. Pax6 is required for the multipotent state of retinal progenitor cells
36. Hu neuronal proteins are expressed in proliferating neurogenic cells
37. Pax6 defines the dimesencephalic boundary by repressing En1 and Pax2
38. A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells
39. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
40. The role of Pax6 in brain patterning
41. Pax-6 is involved in specification of ventral cell types in the hindbrain
42. Gene transfer into cultured mammalian embryos by electroporation
43. Pax-6 is involved in the specification of hindbrain motor neuron subtype
44. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
45. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
46. A role for Pax6 in the normal development of dorsal thalamus and its cortical connections
47. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
48. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
49. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
50. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: I7mplication of Gli2 and Gli3 as primary mediators of Shh signaling
51. Influence of PAX6 gene dosage on development: Overexpression causes severe eye abnormalities
52. LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
53. Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse
54. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
55. Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain
56. Pax6 modulates the dorsoventral patterning of the mammalian telencephalon
57. Pax6 influences the time and site of origin of glial precursors in the ventral neural tube
58. Specification of motor neuron identity by the MNR2 homeodomain protein
59. Shaping morphogen gradients
60. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9
61. Genetic control of dorsal-ventral identity in the telencephalon: Opposing roles for Pax6 and Gsh2
62. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
63. Developmental eye disease - A genome era paradigm
64. Differential expression of LIM homeobox genes among motor neuron subpopulations in the developing chick brain stem
65. Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway
66. Pax-6, a murine paired box gene, is expressed in the developing CNS
67. Roles of Pax-6 in murine diencephalic development
68. Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum
69. Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon