Triggering of peritoneal macrophages with IFN-α/β attenuates the expression of inducible nitric oxide synthase through a decrease in NF-κB activation

Journal of Immunology

Volumn 160, Issue 6, 1998, Pages 2889-2895

  López Collazo, Eduardo ^a   Hortelano, Sonsoles ^a   Rojas, Armando ^b   Boscá, Lisardo ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b PO Box 16042   (Cuba)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; ENZYME INDUCTION; ENZYME SYNTHESIS; INTERFERON PRODUCTION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; ENZYME INDUCTION; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS);

EID: 0242613613     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051.
2. Dileepan, K. N., J. N. Page, Y. Li, and D. J. Stechschulte. 1995. Direct activation of murine peritoneal macrophages for nitric oxide production and tumor cell killing by interferon-gamma. J. Interferon Cytokine Res. 15:387.
3. Nathan, C., and Q. W. Xie. 1994. Nitric oxide synthases: roles, tolls, and controls. Cell 78:915.
4. Xie, Q. W., and C. Nathan. 1994. The high-output nitric oxide pathway: role and regulation. J. Leukoc. Biol. 56:576.
5. Xie, Q. W., R. Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J. Exp. Med. 177:1779.
6. Lowenstein, C. J., E. W. Alley, P. Raval, A. M. Snowman, S. H. Snyder, S. W. Russell, and W. J. Murphy. 1993. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90:9730.
7. Albina, J. E. 1995. On the expression of nitric oxide synthase by human macrophages: why no NO? J. Leukoc. Biol. 58:643.
8. Ding, A. H., C. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
9. Martin, E., C. Nathan, and Q. W. Xie. 1994. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:977.
10. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted IFN-γ genes. Science 259:1793.
11. Kamijo, R., H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S. I. Koh, T. Kimura, S. J. Green, T. W. Mak, T. Taniguchi, and J. Vicek. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263:1612.
12. Xie, Q. W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705.
13. Spink, J., J. Cohen, and T. J. Evans. 1995. The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase. J. Biol. Chem. 270:29541.
14. Deguchi, M., H. Sakuta, K. Uno, K. Inaba, and S. Muramatsu. 1995. Exogenous and endogenous type I interferons inhibit interferon-γ-induced nitric oxide production and nitric oxide synthase expression in murine peritoneal macrophages. J. Interferon Cytokine Res. 15:977.
15. Zhou, A., Z. Chen, J. A. Rummage, H. Jiang, M. Kolosov, I. Kolosova, C. A. Stewart, and R. W. Leu. 1995. Exogenous interferon-γ induces endogenous synthesis of interferon-α and -β by murine macrophages for induction of nitric oxide synthase. J. Interferon Cytokine Res. 15:897.
16. Jiang, H., J. A. Rummage, A. Zhou, Z. Chen, M. J. Herriott, C. A. Stewart, M. Kolosov, and R. W. Leu. 1996. IFN-α/β reconstitutes the deficiency in lipid A-activated AKR macrophages for nitric oxide synthase. J. Immunol. 157:305.
17. Devajyothi, C., I. Kalvakolanu, G. T. Babcock, H. A. Vasavada, P. H. Howe, and R. M. Ransohoff. 1993. Inhibition of interferon-γ-induced major histocompatibility complex class II gene transcription by interferon-β and type β1 transforming growth factor in human astrocytoma cells: definition of cis-element. J. Biol. Chem. 268:18794.
18. Fast, D. J., R. C. Lynch, and R. W. Leu. 1993. Interferon-γ, but not interferon-α/β, synergizes with tumor necrosis factor-α and lipid A in the induction of nitric oxide production by murine L929 cells. J. Interferon Res. 13:271.
19. Terenzi, F., M. J. M. Díaz-Guerra, M. Casado, S. Hortelano, S. Leoni, and L. Boscá. 1995. Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages. J. Biol. Chem. 270:6017.
20. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
21. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
22. Díaz-Guerra, M. J. M., M. Velasco, P. Martin-Sanz, and L. Boscá. 1996. Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. J. Biol. Chem. 271:30114.
23. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573.
24. Schreiber, E., P. Matthias, M. M. Müller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
25. Selden, R. F. 1987. Identification of newly transcribed RNA. In Current Protocols in Molecular Biology. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. John Wiley & Sons Press, New York, Chapter 4.10.
26. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529.
27. Fujihara, M., N. Ito, J. L. Pace, Y. Watanabe, S. W. Russell, and T. Suzuki. 1994. Role of interferon-β in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774. J. Biol. Chem. 269:12773.
28. Zhang, X., E. W. Alley, S. W. Russell, and D. C. Morrison. 1994. Necessity and sufficiency of β-interferon for nitric oxide production in mouse peritoneal macrophages. Infect. Immun. 62:33.
29. Deguchi, M., K. Inaba, and S. Muramatsu. 1995. Counteracting effect of interferon-α/β on interferon-γ-induced production of nitric oxide which is suppressive for antibody response. Immunol. Lett. 45:157.
30. Kreil, T. R., and M. M. Eibl. 1995. Viral infection of macrophages profoundly alters requirements for induction of nitric oxide synthesis. Virology 212:174.
31. Mackichan, M. L., F. Logeat, and A. Israël. 1996. Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-κB. J. Biol. Chem. 271:6084.
32. Kumar, A., J. Haque, J. Lacoste, J. Hiscott, and B. R. G. Williams. 1994. Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc. Natl. Acad. Sci. USA 91:6288.
33. Koromilas, A. E., C. Cantin, A. W. B. Craig, R. Jagus, J. Hiscott, and N. Sonenberg. 1995. The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin κ gene. J. Biol. Chem. 270:25426.
34. Gusella, G. L., T. Musso, S. E. Rottschafer, K. Pulkki, and L. Varesio. 1995. Potential requirement of a functional double-stranded RNA-dependent protein kinase (PKR) for the tumoricidal activation of macrophages by lipopolysaccharide or IFN-α β, but not IFN-γ. J. Immunol. 154:345.
35. Silvennoinen, O., J. N. Ihle, J. Schelissinger, and D. E. Levy. 1993. Interferon-induced nuclear signaling by Jak protein tyrosine kinases. Nature 366:583.
36. Salkowski, C. A., S. A. Barber, G. R. Detore, and S. N. Vogel. 1996. Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes. J. Immunol. 156:3107.
37. Goldring, C. E. P., S. Reveneau, M. Algarte, and J. F. Jeannin. 1996. In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6. Nucleic Acids Res. 24:1682.
38. Ohmori, Y., and T. A. Hamilton. 1993. Cooperative interaction between IFN stimulus response element and κB sequence motifs controls IFN-γ- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J. Biol. Chem. 268:6677.
39. Gao, J., D. C. Morrison, T. J. Parmely, S. W. Russell, and W. J. Murphy. 1997. An interferon-γ-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and lipopolysaccharide. J. Biol. Chem. 272:1226.
40. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. JAK-STAT pathways and transcriptional activation in response to IFNs and other extracellular proteins. Science 264:1415.
41. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Ann. Rev. Biochem. 64:621.
42. Bluyssen, H. A. R., J. E. Durbin, and D. E. Levy. 1996. ISGF3γ p48, a specificity switch for interferon activated transcription factors. Cytokine Growth Factor Rev. 7:11.
43. Qureshi, S. A., M. Salditt-Georgieff, and J. E. Darnell, Jr. 1995. Tyrosine-phosphorylated STAT1 and STAT2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. Proc. Natl. Acad. Sci. USA 92:3829.
44. Kreil, T. R., and M. M. Eibl. 1996. Nitric oxide and viral infection: NO antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo. Virology 219:304.
45. Symons, J. A., A. Alcami, and G. L. Smith. 1995. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity. Cell 81:551.