Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage

Journal of Vascular Research

Volumn 39, Issue 3, 2002, Pages 238-245

  Klabunde, Richard E ^a   Anderson, Denise E ^a  

^a OHIO UNIVERSITY   (United States)

Author keywords

Catalase; Mercaptoethylguanidine; Microcirculation; Nitric oxide; Nitric oxide synthase inhibitor; Peroxynitrite; Platelet activating factor; Reactive oxygen species; Superoxide dismutase

Indexed keywords

1 (2 MERCAPTOETHYL)GUANIDINE; CATALASE; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; GUANIDINE DERIVATIVE; HYPOXANTHINE; N(G) NITROARGININE; NITRIC OXIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ARTICLE; BLOOD VESSEL PERMEABILITY; CHEEK POUCH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MICROCIRCULATION; MICROVASCULATURE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; VASOCONSTRICTION;

ANIMALS; CAPILLARY PERMEABILITY; CRICETINAE; DEXTRANS; FLUORESCEIN-5-ISOTHIOCYANATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; PLATELET ACTIVATING FACTOR; REACTIVE OXYGEN SPECIES; REGIONAL BLOOD FLOW; VASOCONSTRICTOR AGENTS;

EID: 0036311421     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063689     Document Type: Article

References (45)

1. Platelet-activating factor (PAF-acether): Present status
2. Effect of platelet activating factor on leukocyte adhesion to microvascular endothelium
3. Modulation of PAF-induced leukocyte adherence and increased microvascular permeability
4. Vasoconstrictor effects on platelet-activating factor in the hamster cheek pouch microcirculation: Dose-related relations and pathways of action
5. Platelet-activating factor-induced microvascular dysfunction: Role of adherent leukocytes
6. Acute microvascular effects of PAF-acether, as studied by intravital microscopy
7. Superoxide dismutase attenuates effects of platelet-activating factor on gastric microcirculation
8. Effect of platelet-activating factor on microvascular permselectivity: Dose-response relations and pathways of action in the hamster cheek pouch microcirculation
9. Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor
10. Dose-response relationships between platelet activating factor and permeability-surface area product of FITC-dextran 150 in the hamster cheek pouch
11. Platelet-activating factor-induced mucosal dysfunction: Role of oxidants and granulocytes
12. Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C
13. Protein kinase C modulates microvascular permeability through nitric oxide synthase
14. Platelet-activating factor stimulates protein tyrosine kinase in hamster cheek pouch microcirculation
15. L-type calcium channel blockers modulate the microvascular hyperpermeability induced by platelet-activating factor in vivo
16. Platelet-activating factor modulates microvascular permeability through nitric oxide synthesis
17. Obligatory role of nitric oxide in platelet-activating factor-induced microvascular leakage
18. Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways
19. Oxidative stress during platelet-activating factor-induced microvascular dysfunction
20. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage
21. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
22. Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat
23. Characterization of platelet-activating factor induced superoxide anion generation by guinea-pig alveolar macrophages
24. Antioxidants attenuate endotoxin-induced microvascular leakage of macromolecules in vivo
25. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury
26. Oxygen radicals: Effects on intestinal vascular permeability
27. Role of superoxide anion radicals in microvascular permeability and leukocyte behaviour
28. Evidence for participation of hydroxyl radical in increased microvascular permeability
29. Role of superoxide and nitric oxide in platelet-activating factor-induced acute lung injury, hypotension, and mortality in rats
30. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
31. Reactive oxygen species and vascular signal transduction mechanisms
32. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide
33. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
34. Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers: Role of superoxide radical, hydroxyl radical, and peroxynitrite
35. Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells
36. The influence of oxygen free radicals on the permeability of the monolayer of cultured brain endothelial cells
37. Reactive oxygen species as mediators of signal transduction in cardiovascular disease
38. The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat
39. 2+ signaling in vascular endothelial cells
40. NO elicits prolonged relaxation of bovine pulmonary arteries via endogenous peroxynitrite generation
41. Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung
42. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform
43. The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity
44. Modulation by nitric oxide of platelet-activating factor-induced albumin extravasation on the conscious rat
45. Role of eicosanoids but not nitric oxide in the platelet-activating factor-induced increase in vascular permeability in mouse skin