Protein folding and stability of human CDK inhibitor p19INK4d

Journal of Molecular Biology

Volumn 315, Issue 3, 2002, Pages 447-457

  Zeeb, Markus ^a   Rösner, Heike ^a   Zeslawski, Wojciech ^b   Canet, Denis ^c   Holak, Tad A ^b   Balbach, Jochen ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

NMR; P19INK4d; Phenylalanine fluorescence; Protein folding; Protein folding intermediate

Indexed keywords

ANKYRIN; CYCLIN D; CYCLOPHILIN; PHENYLALANINE; PHOSPHOTRANSFERASE INHIBITOR; PROLINE DERIVATIVE; PROTEIN P19; UREA;

ALPHA HELIX; ARTICLE; CELL CYCLE; CONTROLLED STUDY; FLUORESCENCE; HUMAN; ISOMERISM; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; ULTRAVIOLET RADIATION;

EID: 0036304525     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5242     Document Type: Article

References (45)

1. Principles of CDK regulation
2. Cell cycle: Reaching for a role for the Cks proteins
3. Cdk inhibitors in development and cancer
4. CDK inhibitors: Positive and negative regulators of G1-phase progression
5. The retinoblastoma protein and cell cycle control
6. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
7. Cancer cell cycles
8. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
9. INK4a
10. INK4d
11. INK4a: Determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
12. INK4a mutations
13. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
14. Early acquisition of homozygous deletions of p16/p19 during squamous cell carcinogenesis and genetic mosaicism in bladder cancer
15. INK4d-deficient mice are fertile despite testicular atrophy
16. INK4a
17. INK4d
18. Contact order, transition state placement and the refolding rates of single domain proteins
19. INK4d
20. 15N NMR relaxation experiments at two field strengths
21. Proline isomerization and its catalysis in protein folding
22. Following protein folding in real time using NMR spectroscopy
23. Real-time NMR studies of protein folding
24. A protein folding intermediate of ribonuclease T1 characterized at high resolution by 1D and 2D real-time NMR spectroscopy
25. A residue-specific NMR view of the non-cooperative unfolding of a molten globule
26. Characterization of an associated equilibrium folding intermediate of bovine growth hormone
27. Dynamic NMR spectral analysis and protein folding - Identification of a highly populated folding intermediate of rat intestinal fatty acid-binding protein by F-19 NMR
28. NMR investigation of ferricytochrome c unfolding: Detection of an equilibrium unfolding intermediate and residual structure in the denatured state
29. The equilibrium unfolding of Azotobacter vinelandii apoflavodoxin II occurs via a relatively stable folding intermediate
30. Slow cooperative folding of a small globular protein HPr
31. Real-time refolding studies of 6-F-19-tryptophan labeled Escherichia coli dihydrofolate reductase using stopped- flow NMR spectroscopy
32. Slow folding of muscle acylphosphatase in the absence of intermediates
33. Characterization of the unfolding pathway of hen egg white lysozyme
34. Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy
35. Real-time NMR studies on folding of mutants of barnase and chymotrypsin inhibitor 2
36. Stability and folding of the tumour suppressor protein p16
37. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
38. Elucidating the folding problem of helical peptides using empirical parameters. 2. Helix macrodipole effects and rational modification of the helical content of natural peptides
39. Elucidating the folding problem of helical peptides using empirical parameters. 3. Temperature and pH dependence
40. INK4a
41. Determination and analysis of urea and guanidine hydrochloride denaturation curves
42. 1 are strongly altered by the replacement of cis-proline 39 with alanine
43. Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions
44. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures