Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes

European Journal of Immunology

Volumn 31, Issue 3, 2001, Pages 699-707

  Delgado, Maria Belen ^a   Clark Lewis, Ian ^b   Loetscher, Pius ^a   Langen, Hanno ^c   Thelen, Marcus ^d   Baggiolini, Marco ^a   Wolf, Marlene ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Cathepsin G; Lymphocyte; NK cell; SDF 1; Serine proteinase

Indexed keywords

CATHEPSIN G; CHYMOSTATIN; DIPEPTIDYL PEPTIDASE IV; DIPROTIN A; LEUCINE; SERINE; SERINE PROTEINASE INHIBITOR; STROMAL CELL DERIVED FACTOR 1; TRITON X 100;

AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENZYME BINDING; ENZYME MECHANISM; ENZYME RELEASE; GENE ACTIVITY; GENE INACTIVATION; HUMAN; HUMAN CELL; LYMPHOCYTE MEMBRANE; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; T LYMPHOCYTE;

AMINO ACID SEQUENCE; B-LYMPHOCYTES; CATHEPSINS; CELLS, CULTURED; CHEMOKINES, CXC; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; T-LYMPHOCYTES;

EID: 0035079801     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200103)31:3<699::AID-IMMU699>3.0.CO;2-6     Document Type: Article

References (49)

1. Signal sequence trap: A cloning strategy for secreted proteins and type I membrane proteins
2. Molecular cloning and structure of a pre-B-cell growth-stimulating factor
3. Chemokines and leukocyte traffic
4. Chemokines and their receptors in lymphocyte traffic and HIV infection
5. HIV-1 entry cofactor: Functional cDNA cloning of a seventransmembrane, G protein-coupled receptor
6. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
7. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
8. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
9. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
10. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
11. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
12. HIV coreceptor downregulation as antiviral principle: SDF- 1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication
13. Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues
14. Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage
15. Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction
16. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1
17. Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage
18. Developmental regulation of the human cathepsin G gene in myelomonocytic cells
19. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines
20. Synthesis and expression in Escherichia coli of the gene encoding monocytederived neutrophil-activating factor: Biological equivalence between natural and recombinant neutrophil-activating factor
21. Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis and receptor binding activities
22. Interleukin-8 antagonists generated by N-terminal modification
23. Isolation of the CXC chemokines ENA-78 GROα and GROgamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity-Functional comparison of different natural isoforms
24. Amino-terminal processing of chemokine ENA-78 regulates biological activity
25. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3
26. RANTES and MCP-3 antagonists bind multiple chemokine receptors
27. Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant
28. Human chemokines: An update
29. Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor
30. CD26: A surface protease involved in T-cell activation
31. Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
32. Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1α
33. Amino-terminal truncation of chemokines by CD26/dipeptidylpeptidase IV - Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection
34. CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3
35. Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leukocytes
36. Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase- mediated proteolytic activity
37. Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins
38. Cell surface-bound elastase and cathepsin G on human neutrophils: A novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases
39. Angiotensin II generation at the cell surface of activated neutrophils: Novel cathepsin G-mediated catalytic activity that is resistant to inhibition
40. Cathepsin G enhances human natural killer cytotoxicity
41. Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: Evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor
42. Inducible binding of bioactive cathepsin G to the cell surface of neutrophils. A novel mechanism for mediating extracellular catalytic activity of cathepsin G
43. Cathepsin G binds to human lymphocytes
44. Chemical synthesis, purification and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2
45. Rapid killing of actinomycin D-treated tumor cells by human mononuclear cells. I. Effectors belong to the monocyte-macrophage lineage
46. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes
47. Identification of proteins by matrix-assisted laser desorption ionization mass spectrometry following in-gel digestion in low-salt, nonvolatile buffer and simplified peptide recovery
48. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration
49. Molecular cloning of human cathepsin G: Structural similarity to mast cell and cytotoxic T lymphocyte proteinases