The biology and clinical uses of blood stem cells

Blood

Volumn 89, Issue 7, 1997, Pages 2233-2258

  To, L B ^a   Haylock, D N ^a   Simmons, P J ^a   Juttner, C A ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARMUSTINE; CELL ADHESION MOLECULE; CISPLATIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOKINE; ERYTHROPOIETIN; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MELPHALAN; METHOTREXATE; MILODISTIM; MITOXANTRONE; PREDNISOLONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR; VINCRISTINE;

BLOOD CELL; BONE MARROW TOXICITY; BONE MARROW TRANSPLANTATION; BREAST CANCER; CANCER CHEMOTHERAPY; CELL TRANSPLANTATION; CLINICAL TRIAL; COLONY FORMING UNIT GM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEVER; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKAPHERESIS; NEUTROPENIA; NONHUMAN; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030951437     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.7.2233     Document Type: Review

References (290)

1. Gratwohl A, Baldomero H, Hermans J: Hematopoietic precursor cell transplants in Europe: Activity in 1994. Report from the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 17:137, 1996
2. Juttner CA, To LB, Haylock DN, Branford A, Kimber RJ: Circulating autologous stem cells collected in very early remission from acute non-lymphoblastic leukaemia produce prompt But incomplete hemopoietic reconstitution after high dose melphalan or supralethal chemoradiotherapy. Br J Haematol 61:739, 1985
3. Reiffers J, Bernard P, David B, Vezon G, Sarrat A, Marit G, Moulinier J, Broustet A: Succesful autologous transplantation with peripheral blood Hemopoietic cells in a patient with acute leukaemia. Exp Hematol 14:312, 1968
4. Korbling M, Dorken B, Ho AD, Pezzuto A, Hunstein W, Fliedner TM: Autologous transplantation of blood derived hemopoietic stem cells after myeloablative therapy in a patient with Burkett's lymphoma. Blood 67:629, 1986
5. Kessinger A, Armitage JO, Landmark JD, Weisenberger DD: Reconstitution of hematopoietic function with autologous cryopreserved circulating stem cells. Exp Hematol 14:192, 1986
6. Bell AJ, Oscier DG, Figes A, Hamblin TJ: Use of circulating stem cells to accelerate myeloid recovery after autologous bone marrow transplantation. Br J Haematol 67:252, 1987
7. Hershko C, Ho WG, Gale RP, Cline MJ: Cure of aplastic anaemia in paroxysmal nocturnal hemoglobulinuria by marrow transfusion from identical twin: Failure of peripheral leucocyte transfusion to correct marrow aplasia. Lancet 1:945, 1979
8. Abrams RA, Glaubiger D, Appelbaum FR, Deisseroth AB: Result of attempted hematopoietic reconstitution using isologous, peripheral blood mononuclear cells: A Case Report. Blood 56:516, 1980
9. Korbling M, Burke P, Braine H, Elfenbein G, Santos GW, Kaizer H: Successful engraftment of blood derived normal hemopoietic stem cells in chronic myelogenous leukemia, Exp Hematol 9:684, 1981
10. Goldman JM, Th'ing KH, Park DS, Spiers ASD, Lowenthal RM, Ruutu T: Collection, cryopreservation and subsequent viability of haemopoietic stem cells intended for treatment of chronic granulocytic leukaemia in transformation. Br J Haematol 40:185, 1978
11. Korbling M, Fliedner TM: History of blood stem cell transplants. Blood stem cell transplants, in Gale RP, Juttner CA, Henon P (eds): Peripheral Blood Stem Cell Autografts. New York, NY, Cambridge University Press, 1994, p 9
12. Richman CM, Weiner RS, Yankee RA: Increase in circulating stem cells following chemotherapy in man. Blood 47:1031, 1976
13. Lohrmann HP, Schreml W, Fliedner TM, Heimpel H: Reaction of human granulopoiesis to high does cyclophosphamide therapy. Blut 38:9, 1979
14. Stiff PJ, Murgo AJ, Wittes MF, DeRisi MF, Clarkson BD: Quantification of the peripheral blood colony forming unit-culture rise following chemotherapy - Could leukocytaphereses replace bone marrow for autologous transplantation? Transfusion 23:500, 1983
15. To LB, Haylock DN, Kimber RJ, Juttner CA: High Levels of circulating hemopoietic stem cells in very early remission from acute non-lymphoblastic leukaemia and their collection; and cryopreservation. Br J Haematol 58:399, 1984
16. Reiffers J, Bernard PH, Marit G, Sarrat A, Froideval JL, Broustet A, Vezon G: Collection of blood-derived haemopoietic stem cells and applications for autologous transplantation. Bone Marrow Transplant 1:371, 1986 (suppl 1)
17. To LB, Sheppard KM, Haylock DN, Dyson PG, Charles P, Thorpe DL, Dale BM, Dart GW, Roberts MM, Sage RE, Juttner CA: Single high doses of cyclophosphamide enable the collection of high numbers of hemopoietic stem cells from the peripheral blood. Exp Hematol 18:442, 1989
18. Duhrsen U, Villeval J-L, Boyd J, Kannourakis G, Morstyn G, Metcalf D: Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72:2074, 1988
19. Socinski MA, Cannistra SA, Elias A, Antman KH, Schnipper L, Griffin JD: Granulocyte-macrophage colony-stimulating factor expands the circulating haemopoietic progenitor cell compartment in man. Lancet 1:1194, 1988
20. Sheridan WP, Begley CG, Juttner CA, Szer J, To LB, Maher D, McGrath KM, Morstyn G, Fox RM: Effect of peripheral blood progenitor cells mobilized by filgrastim (G-CSF) on platelet recovery after high does chemotherapy. Lancet 339:640, 1992
21. Gianni AM, Siena S, Bregni M, Tarella C, Stern AC, Piler A, Bonadonna G: Granulocyte-macrophage colony-stimulating factor to harvest circulating hemopoietic stem cells for autotransplantation. Lancet 2:580, 1989
22. Elias AD, Ayash L, Anderson KC, Hunt M, Wheeler C, Schwartz G, Tepler I, Mazanet R, Lynch C, Pap S: Mobilization of peripheral blood progenitor cells by chemtherapy and granulocyte macrophage colony stimulating factor for hematologic support after high dose intensification for breast cancer. Blood 79:3036, 1992
23. Fukuda M, Kojima S, Matsumoto K, Matsuyama T: Autotransplantation of peripheral blood stem cells mobilized by chemotherapy and recombinant human granulocyte colony-stimulating factor in childhood neuroblastoma and non-Hodgkin's lymphoma. Br J Haematol 80:327, 1992
24. Haas R, Mohle R, Fruhauf S, Goldschmidt H, Witt B, Flentje M, Wannenmacher M, Hunstein W: Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma. Blood 83:3787, 1994
25. Schwartzberg LS, Birch R, Hazelton B, Tauer KW, Lee P, Altemose MD, George C, Blanco R, Wittlin F, Cohen J, Muscato J, West WH: Peripheral blood stem cell mobilization by chemotherapy with and without recombinant human granulocyte colony-stimulating factor. J Hematother 1:317, 1992
26. Schwartzberg LS: Peripheral blood stem cell mobilization in the out-patient setting, in Wunder EW, Henon PR (eds): Peripheral Blood Stem Cell Autografts. Heidelberg, Germany, Springer-Verlag, 1993, p 177
27. To LB, Russell J, Moore S, Juttner CA: Residual Leukaemia cannot be detected in very early remission peripheral blood stem cell collections in acute non-lymphoblastic leukaemia. Leuk Res 11:327, 1987
28. Ross AA, Cooper BW, Lazarus HM, Mackay W, Moss TJ, Ciobanu N, Tallman MS, Kennedy J, Davidson NE, Sweet D, Winter C, Akhard L, Jansen J, Copelan E, Meagher RC, Herzig RH, Klumpp TR, Kahn DG, Warner NE: Detection and viability of tumour cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques. Blood 82:2605, 1993
29. Ross AA, Miller GW, Moss TJ, Kahn DG, Warner NE, Sweet DL, Louie KG, Schneidermann E, Pecora AL, Meagher RC, Herzig RH, Collins RH, Fay JW: Immunocytochemical detection of tumour cells in bone marrow and peripheral blood stem cell collections from patients with ovarian cancer. Bone Marrow Transplant 15:929, 1995
30. Brugger W, Brass KJ, Glatt M, Weber F, Mertelsrnann R, Kanz L: Mobilization of tumour cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 83:636, 1994
31. Moss TJ, Cairo M, Santana VM, Weinthal J, Hurvitz C, Bostrom B: Clonogenicity of circulating neuroblastoma cells: Implications regarding peripheral blood stem cell transplantation. Blood 83:3085, 1994
32. Moss TJ, To LB, Pantel K: Evaluation of grafts for occult tumor cells. J Hematother 3:163, 1994
33. Bregni M, Magni M, Siena S, Di Nicola M, Bonadonna G, Gianni AM: Human peripheral blood hematopoietic progenitors are optimal targets of retroviral mediated gene transfer. Blood 80:1418, 1992
34. Dunbar CD, Cottler-Fox M, O'Shaughnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Marc Stewart F, Leitman SF, Wilson WH, Cowan K, Young NS, Nienhuis AW: Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood 85:3048, 1995
35. + marrow cells in patients with breast cancer or neuroblastoma. Blood 77:1717, 1991
36. + cells into the myeloid lineage. Blood 89:1405, 1992
37. Shpall EJ, Jones RB, Bast RC Jr, Johnston CS, Ross M, Anderson I, Peters WP: Immunopharmacologic purging of breast cancer from bone marrow, in Dicke KA, Armitage JO, Decke Evinger MJ (eds): Autologous Bone Marrow Transplantation. Proceedings of the Fifth International Symposium on Autologous Bone Marrow Transplantation. Omaha, NE, The University of Nebraska Medical Center, 1991, p 379
38. Shpall EJ, Jones RB, Bearman SI, Franklin WA, Archer PG, Curiel T, Bitter M, Claman HN, Stemmer SM, Purdy M, Myers SE, Hami L, Taffs S, Heimfeld S, Hallagan J, Berenson RJ: Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemtherapy: Influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment. J Clin Oncol 12:28, 1994
39. + cells. Blood 84:2930, 1994
40. Simmons PJ, Leavesley DI, Levesque J-P, Swart BW, Haylock DN, To LB, Ashman LK, Juttner CA: The mobilization of primitive hemopoietic progenitors into the peripheral blood. Polyfunctionality of hemopoietic regulators: The Metaclf Forum. Stem Cells 12:187, 1994 (suppl 1)
41. To LB, Dyson PG, Juttner CA: Cell-dose effect in circulating stem cell autografting. Lancet 2:404, 1986
42. Siena S, Bregni M, Brando B, Belli N, Ravagnani F, Gandola L, Stern AC, Lansdorp PM, Bonadonna G, Gianni AM: Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients. Blood 77:400, 1991
43. To LB, Roberts MM, Haylock DN, Dyson PG, Branford AL, Thorp D, Ho JQKH, Dart GW, Davy MLJ, Olweny CLM, Abdi E, Juttner CA: Comparison of haematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow transplants and allogeneic bone marrow transplants. Bone Marrow Transplant 9:277, 1992
44. Bender JG, To LB, Williams S, Schwartzberg LS: Defining a therapeutic dose of peripheral blood stem cells. J Hematother 1:329, 1992
45. To LB, Roberts MM, Rawling CM, Dyson PG, Rawling TP, Haylock DN, Juttner CA: Establishment of a clinical threshold cell dose: Correlation between CFU-GM and duration of aplasia, in Wunder E, Sovalat H, Henon PR, Serke S (eds): Hematopoietic Stem Cells: The Mulhouse Manual. Dayton, OH, AlphaMed, 1994, P 15
46. + cells in peripheral and cord blood by flow cytometry. Exp Hematol 22:1003, 1994
47. To LB, Juttner CA, Stomski F, Vadas MA, Kimber RJ: Immune reconstitution following peripheral blood stem cell autografting (letter). Bone Marrow Transplant 2:111, 1987
48. Roberts MM, To LB, Gillis D, Mundy J, Rawling C, Ng K, Juttner CA: Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation and allogeneic bone marrow transplantation. Bone Marrow Transplant 17:469, 1993
49. Verbik DJ, Jackson JD, Pirruccello SJ, Patil KD, Kessinger A, Joshi SS: Functional and phenotypic characterization of human peripheral blood stem cell harvests. Blood 85:1964, 1995
50. Russell N, Gratwohl A, Schmitz N: The place of blood stem cells in allogeneic transplantation. Br J Haematol 93:747, 1996
51. Wagner JE: Umbilical cord blood transplantation. Transfusion 35:619,694, 1995
52. Goodman J, Hodgson G: Evidence for stem cells in the peripheral blood of mice. Blood 19:702, 1962
53. Cavins JA, Stuart CS, Scheer E, Ferrebee T, Ferrebee JW: The recovery of lethally irradiated dogs given infusions of autologous leukocytes preserved at -80 C. Blood 23:38, 1964
54. Micklem HS, Anderson N, Ross R: Limited potential of circulating hemopoietic stem cells. Nature 256:41, 1975
55. Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED: Demonstration of hemopoietic stem cells in the peripheral blood of baboons by cross-circulation. Blood 50:537, 1977
56. Cherktov JL, Gurevitch OA, Udalov GA: Self maintenance ability of circulating hemopoietic stem cells. Exp Hematol 10:90, 1982
57. Abrams RA, McCormack K, Bowles C, Deisseroth AB: Cycolphosphamide treatment expands the circulating hematopoietic stem cell pool in dogs. J Clin Invest 67:1392, 1981
58. McCredie KB, Hersh EM, Freireich EJ: Cells capable of colony formation in the peripheral blood of man. Science 171:293, 1971
59. Lohrmann HP, Schreml W, Lang W, Betzier M, Fliedner TM, Heimpel H: Changes of granulopoiesis during and after adjuvant chemotherapy of breast cancer. Br J Haematol 40:369, 1978
60. Verma DS, Fisher R, Spitzer G, Zander AR, McCredie KL, Dicke KA: Diurnal changes in circulating myeloid progenitor cells in man. Am J Haematol 9:185, 1980
61. Jehn U, Kern K, Wachholz K, Holzel D: Prognostic value of in vitro growth pattern of colony forming cells in adult acute leukaemia. Br J Cancer 47:423, 1983
62. Hibben JA, Njoku OS, Matutes F, Lewis SM, Goldman JM: Myeloid progenitor cells in the circulation of patients with myelofibrosis and other myeloproliferative disorders. Br J Haematol 57:495, 1984
63. Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger DD: Reconstitution of human hematopoietic function with autologous cryopreserved circulating stem cells. Exp Haematol 14:192, 1986
64. Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger DD: Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 71:723, 1988
65. Nothdurft W, Bruch C, Fliedner TM, Ruber E: Studies on the regeneration of the CFUc-population in blood and bone marrow of lethally irradiated dogs after autologous transfusion of cryopreserved mononuclear blood cells. Scand J Haematol 19:470, 1977
66. Carbonell F, Calvo W, Fliedner M, Kratt E, Gerhartz H, Korbling M, Nothdurft W, Ross WM: Cytogenetic studies in dogs after total body irradiation and allogeneic transfusion with cryopreserved blood mononuclear cells: Observations in long-term chimeras: Intern J Cell Cloning 2:81, 1984
67. McCredie B, Freireich EJ, Hersh EM, Curtis JE, Kaizer H, Anderson K: Early bone marrow recovery after chemotherapy following the transfusion of peripheral blood leukocytes in identical twins. Proc Am Assoc Cancer Res 2:11, 1970 (abstr)
68. Valdimarsson K, Holt PJL, Moss PD, Hobbs JR: Treatment of chronic mucocutaneous candidiasis with leucocytes from HL-A compatible sibling. Lancet 1:469, 1972
69. Cline MJ, Golde DW: Mobilization of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin. Exp Hematol 5:186, 1977
70. Barrett AJ, Longhurst P, Sneath P, Watson JG: Mobilization of CFU-C by exercise and ACTH induced stress in man. Exp Hematol 6:590, 1978
71. To LB, Haylock DN, Juttner CA, Kimber RJ: The effect of monocytes on the peripheral blood CFU-c assay system. Blood 62:112, 1983
72. Korbling M, Fliedner TM, Pflieger H: Collection of large quantaties of granulocyte macrophage progenitor cells (CFUc) in man by means continuous-flow leukapheresis. Scand J Haematol 24:22, 1980
73. To LB, Dyson PG, Branford AL, Russell JA, Haylock DN, Ho JQK, Kimber RJ, Juttner CA: Peripheral blood stem cells collected in very early remission produce rapid and sustained autologous haemopoietic reconstitution in acute non-lymphoblastic leukaemia. Bone Marrow Transplant 2:103, 1987
74. Juttner CA, To LB, Ho JQK, Bardy PG, Dyson PG, Haylock DN, Kimber RJ: Early lympho-haemopoietic recovery after autografting using peripheral blood stem cells in acute non-lymphoblastic leukaemia. Transplant Proc 20:40, 1988
75. Juttner CA, To LB, Haylock DN, Dyson PG, Thorp D, Dart GW, Ho JQK, Horvath N, Bardy P: Autologous blood stem cell transplantation. Transplant Proc 21:2929, 1989
76. Reiffers L, Leverger G, Marit G, Castaigne S, Tilly H, Lepage E, Henon E, Douay L, Troussard X: Hematopoietic reconstitution after autologous blood stem cell transplantation, in Gale RP, Champlin RE (eds): Bone Marrow Transplantation: Current Controversies. Proceedings of Sandoz-UCLA Symposium. New York, NY, Liss, 1988, p 313
77. Molineux G, Pojda Z, Hampson IN, Lord BI, Dexter TM: Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. Blood 76:2153, 1990
78. Neben S, Marous K, Minch P: Mobilization of hematopoietic stem and progenitor cell populations from marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 81:1960, 1993
79. Yan X-Q, Hartley C, McElroy P, Chang A, McCrea, McNiece I: Peripheral blood progenitor cells mobilized by recombinant human granulocyte colony-stimulating factor plus recombinant rat stem cell factor contain long-term engrafting cells capable of cellular proliferation for more than two years as shown by serial transplantation in mice. Blood 85:2303, 1995
80. Starzl TE, Demetris AJ, Trucco M, Ricordi C, Ildstad S, Terasaki PI, Murase N, Kendall RS, Kocova M, Rudert WA, Zeevi A, Thiel DV: Chimerism after liver transplantation for type IV glycogen storage disease and type I Gaucher's disease. N Engl J Med 328:745, 1993
81. Dexter TM, Allen TD, Simmons PJ: Marrow biology and stem cells, in Dexter TM, Garland JM, Testa NG (eds): Colony Stimulating Factors: Molecular & Cellular Biology. New York, NY, Dekker, 1990, p 1
82. Tavassoli M, Hardy CL: Molecular basis of homing of intravenously transplanted stem cells: Blood 76:1059, 1990
83. Gordon MY: Haemopoietic progenitor cell binding to the stromal environment in vitro. Exp Hematol 18:837, 1990
84. Verfaillie C, Blakolmer K, McGlave P: Purified primitive human haemopoietic progenitors with long-term in vitro repopulating ability selectively adhere to irradiated bone marrow stroma. J Exp Med 172:509, 1990
85. Long MW: Blood cell cytoadhesion molecules. Exp Hematol 20:288, 1992
86. Simmons PJ, Zannettino A, Gronthos S, Leavesley D: Potential adhesion mechanisms for localisation of haemopoietic progenitors to bone marrow stroma. Leuk Lymphoma 12:353, 1994
87. Tsai S: Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin. Blood 69:1587, 1987
88. Simmons PJ, Masinovsky B, Longenecker BM, Berenson R, Torok-Storb B, Gallatin WM: Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitors. Blood 80:388, 1992
89. To LB: Mobilizing and collecting blood stem cells, in Gale RP, Juttner CA, Henon P (eds): Peripheral Blood Stem Cell Autografts. New York, NY, Cambridge University Press, 1994, p 56
90. Papayannopoulou T, Nakamoto B: Peripheralisation of hemopoietic progenitors in primates treated with anti-VLA-4 integrin. Proc Natl Acad Sci USA 90:9374; 1993
91. + hematopoietic progenitor cells: Comparison of cytokine mobilised blood stem cells with normal bone marrow and peripheral blood. J Hematother 2:483, 1993
92. Turner ML: Regulation of hematopoietic progenitor cell migration, mobilization and homing. Stem Cells 12:227, 1994
93. + myeloid progenitors: Role of marrow stromal, fibroblast and cytomatrix components. Exp Hematol 19:63, 1991
94. H1 cells to bone marrow stroma. J Clin Invest 90:358, 1992
95. Williams DA, Rios M, Stephens C, Patel VP: Fibronectin and VLA-4 in haemopoietic stem cell-microenvironment. Nature 352, 1991
96. Jacobson K, Kravitz J, Kincade PW, Osmond DG: Adhesion receptors on bone marrow stromal cells: In vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and γ-irridiated mice. Blood 87:73, 1996
97. + cells predict a rapid platelet recovery after peripheral blood stem cell transplantation. Blood 85:3313, 1995
98. + cells to fibronectin in an activation-dependent way. Blood 81:344, 1993
99. Kovach NL, Lin N, Yednock T, Harlan JM, Broudy VC: Stem cell factor modulates activity of α4β1 and α5β1 integrins expressed on hematopoietic cell lines. Blood 85:59, 1995
100. Levesque J-P, Leavesley DI, Niutta S, Vadas M, Simmons PJ: Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. J Exp Med 1805, 1995
101. + hemopoietic progenitors. Blood 88:1168, 1996
102. Lesley J, Hyman R: CD44 can be activated to function as a hyaluronic acid receptor in normal murine T-cells. Eur J Immunol 22:2719, 1992
103. d mice. Leukaemia 5:75, 1991
104. Leary AG, Ogawa M: Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors. Blood 69:953, 1987
105. Coates TD: Behavioural aspects of neutrophil motility. Curr Opin Hematol 3:41, 1996
106. To LB, Rawling C, Andary C, Rawling T, Haylock A, Thorp D, Dyson P, Juttner CA: The efficacy of sequential/combined IL-3/ GM-CSF administration in peripheral blood (PB) progenitor mobilization. Blood 82:319a, 1993 (abstr, suppl 1)
107. Orazi A, Cattoretli G, Schiro R, Siena S, Bregni M, DiNicola M, Gianni AM: Recombinant human interleukin-3 and recombinant human granulocyte-macrophage colony-stimulating factor administered in vivo after high dose cyclophosphamide cancer chemotherapy: Effect on hematopoiesis and microenvironment of bone marrow. Blood 79:2610, 1992
108. Dorudi S, Hart IR: Mechanisms underlying invasion and metastasis. Curr Opin Oncol 5:130, 1993
109. 2 in patients with advanced cancer. Aust NZ J Med 22:600, 1992
110. Kotasek DD, Shepherd KM, Sage RE, Dale BM, Norman JE, Charles P, Gregg CA, Pillow A, Bolton A: Factors affecting blood stem cell collections following high dose cyclophosphamide mobilization in lymphoma, myeloma and solid tumors. Bone Marrow Transplant 9:11, 1992
111. Jagannath S, Vesole DH, Glenn L, Crowley J, Barlogie B: Low risk intensive therapy for-multiple myeloma with combined autologous bone marrow and blood stem cell support. Blood 80:1666, 1992
112. Gianni AM, Bregni M, Siena S, Orazi A, Stern C, Gondola L, Bonadonna G: Recombinant human granulocyte-macrophage colony-stimulating factor reduces hematologic toxicity and widens clinical applicability of high-dose cyclophosphamide treatment in breast cancer and non-Hodgkin's lymphoma. J Clin Oncol 8:768, 1990
113. Brugger W, Bross K, Frisch J, Dern P, Weber B, Mertelsmann R, Kanz L: Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following polychemo-therapy with etoposide, ifosfamide and cisplatin. Blood 70:1193, 1992
114. Pettengell R, Morgenstern GR, Woll PJ, Chang J, Rowlands M, Young R, Radford JA, Scarffe JH, Testa NG, Crowther D: Peripheral blood progenitor cell transplantation in lymphoma and leukaemia using a single leukapheresis. Blood 82:3770, 1993
115. Haynes A, Hunter A, McQuaker G, Anderson S, Bienz N, Russell NH: Engraftment characteristics of peripheral blood stem cells mobilised with cyclophosphamide and the delayed addition of G-CSF. Bone Marrow Transplant 16:359, 1995
116. Weaver CH, Hazelton B, Birch R, Palmer P, Allen C, Schwartzberg, West W: An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood 86:3961, 1995
117. Abboud CN, Reykdal S, Liesveld JL, Belanger TJ, Haug JS, Rosell KE, Kempski MC, Flesher WR, DiPersio JF: Prospective randomized trial (NCI/92-0010), comparing the efficacy of hematopoietic growth factors for mobilizing peripheral blood stem cells (PBSC) in autologous bone marrow transplantation: II. Progenitor mobilization kinetics. Blood 86:463a, 1995 (abstr, suppl 1)
118. Winter JN, Lazarus HM, Rademaker AF, Bauman A, Cooper B, Thomas R, Gordon LI, Tallman MS, Rubin H, Gerson S, Miller LL: Comparison of PIXY321 and GM-CSF for mobilization of peripheral blood progenitor cells (PBPC) in advanced breast cancer. Blood 86:578a, 1995 (abstr, suppl 1)
119. DeLuca E, Sheridan WP, Watson D, Szer J, Begley CG: Prior chemotherapy does not prevent effective mobilisation by G-CSF of peripheral blood progenitor cells. Br J Cancer 66:893, 1992
120. Demuynck H, Pettengell R, deCampos E, Dexter TM, Testa NG: The capacity of peripheral blood stem cells mobilised with chemotherapy plus G-CSF to repopulate irradiated marrow stroma in vitro is similar to that of bone marrow. Eur J Cancer 28:381, 1992
121. Bensinger W, Singer J, Appelbauf F, Lilleby K, Longin K, Rowley S, Clarke ER, Clift R, Hansen J, Shields T, Storb R, Weaver C, Weiden P, Buckner CD: Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte colony stimulating factor. Blood 81:3158, 1993
122. Chao NJ, Schriber JR, Grimes K, Long GD, Negrin RS, Raimondi CM, Horning SJ, Brown SL, Miller L, Blume KG: Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy. Blood 81:2031, 1993
123. Basser RL, To LB, Begley CG, Juttner CA, Maher DW, Szer J, Cebon J, Collins J, Russell I, Fox RM, Sheridan WP, Green MD: Adjuvant treatment of women with high risk breast cancer using multiple cycles of high-dose chemotherapy supported by filgrastim (G-CSF)-mobilised peripheral blood progenitor cells. Clin Cancer Res 1:715, 1995
124. Schmitz N, Dreger P, Suttorp M, Rohwedder EB, Haferlach T, Loffler H, Hunter A, Russell NH: Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor). Blood 85:1666, 1995
125. +dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease. Blood 86:2842, 1995
126. Grigg AP, Roberts AW, Raunow H, Houghton S, Layton JE, Boyd AW, McGrath KM, Maher D: Optimizing dose and scheduling of filgratism (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood 86:4437, 1995
127. Harada M, Nagafuji K, Fujisaki T, Kubota A, Mizuno S-I, Takenaka K, Miyamoto T, Ohno T, Gondo H, Kuroiwa M, Okamura T, Inaba S, Niho Y: G-CSF - induced mobilization of perpheral blood stem cells from healthy adults for allogeneic transplantation. J Hematother 5:63, 1996
128. Bensinger W, Weaver FR, Appelbaum FR, Rowley S, Demirer J, Sanders R, Storb R, Buckner CD: Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor. Blood 85:1655, 1995
129. Hoglund M, Smedmyr B, Simonsson B, Totterman T, Bengtsson M: Dose-dependent mobilisation of haematopoietic progenitor cells in healthy volunteers receiving glycosylated rHuG-CSF. Bone Marrow Transplant 18:19, 1996
130. Waller CF, Bertz H, Wenger MK, Fetscher S, Hardung M, Engelhardt M, Behringer D, Lange W, Mertelsmann R, Finke J: Mobilization of peripheral blood progenitor cells for allogeneic transplantalion: Efficacy and toxicity of a high-dose rhG-CSF regimen. Bone Marrow Transplant 18:279, 1996
131. Mire-Sluis AR, Das RG, Thorpe R: The international standard for granulocyte colony stimulating factor (G-CSF). Evaluation in an international collaborative study. J Immunol Methods 179:117, 1995
132. Gisselbrecht C, Prentice G, Bacigalupo A, Biron P, Milpied N, Rubie H, Cunningham D, Legros M, Pico JL, Linch DC, Burnett AK, Scarffe JH, Siegert W, Yver A: A phase III randomised placebo-controlled study of lenograstim (glycosylated rHuG-CSF) in 315 paediatric and adult autologous or allogeneic bone marrow transplant patients. Lancet 343:696, 1994
133. Hoglund M, Bengesson M, Cour-Chabernaud Y, Dabouz-Harrpuche F, Simonsson B, Smedmyr B, Torrerman T: Glycosylated rHuG-CSF is more potent than non-glycosylated rHuG-CSF in mobilisation of peripheral blood progenitor cells (PBPC) in healthy volunteers. Blood 86:464a, 1995 (abstr, suppl 1)
134. Andrews G, Knitter GH, Bartelmex SH, Langley KE, Farrar D, Hendren RW, Appelbaum FR, Bernstein ID, Zsebo KM: Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates. Blood 78:1975, 1991
135. Andrews RG, Bensinger WI, Knitter GH, Bartelmez SH, Longin K, Bornstein ID, Appelbaum FR, Zsebo KR: The ligand for c-kit,_stem cell factor, stimulates the circulation of cells that engraft lethally irradiated baboons. Blood 80:2715, 1992
136. Briddell RA, Hartley CA, Smith KA, McNiece IK: Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential. Blood 82:1720, 1993
137. Andrews RG, Briddell RA, Knitter GH, Opie T, Bronsden M, Myerson D, Appelbaum FR, McNiece IK: In vivo synergy between recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in baboons: Enhanced circulation of progenitor cells. Blood 84:800, 1994
138. Basser R, Begley CG, Mansfield R, To LB, Juttner C, Maher D, Fox R, Cebon J, Szer J, Grigg A, Clark K, Marty J, Menchaca D, Thompson B, Russell I, Collins J, Green M: Mobilization of PBPC by priming with stem cell factor (SCF) before filgratim compared to concurrent administration. Blood 86:687a, 1995 (abstr, suppl 1)
139. Begley CG, Basser R, Mansfield R, Maher B, To LB, Juttner CA, Fox R, Cebon J, Grigg A, Szer J, McGrath K, Thomson B, Sheridan W, Menchaca D, Collins J, Russell I, Green M: Randomized prospective study demonstrating a prolonged effect of SCF with G-CSF (Filgrastim) on PBPC in untreated patients: Early results. Blood 84:25a, 1994 (abstr, suppl 1)
140. Glaspy J, LeMaistre CF, Lill M, Jones R, Moore R, Briddell, Menchaca D, Turner S, Shpall EJ: Dose-response of 7 day administration of recombinant methionyl human stem cell factor (SCF) in combination with filgrastim (G-CSF) for progenitor cell mobilization in patients with stage II-IV breast cancer. Blood 86:463a, 1995 (abstr, suppl 1)
141. Haas R, Ho AD, Bredthauer U, Cayeux, Egerer G, Knauf W, Hunstein W: Successful autologous transplantation of blood stem cells mobilized with recombinant human granulocyte-macrophage colony-stimulating factors. Exp Hematol 18:94, 1990
142. Aglietta M, Piacibello W, Sanavio F, Stacchini A, Apra F, Schena M, Mossetti C, Carnino F, Caligaris-Cappio F, Gavosto F: Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor. J Clin Invest 83:551, 1995
143. Villeval J-L, Dührsen U, Morstyn G, Metcalf D: Effect of recombinant human granulocyte-macrophage colony stimulating factor on progenitor cells in patients with advance malignancies. Br J Haematol 74:36, 1990
144. Peters WP, Rosner G, Ross M, Vredenburgh J, Meisenberg B. Gilbert C, Kurtzberg J: Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy. Blood 81:1709, 1993
145. Lopez AF, To LB, Yang YC, Gamble JR, Shannon MF, Burns GF, Dyson PG, Juttner CA, Clark S, Vadas MA: Stimulation of proliferation, differentiation and function of human cells by primate interleukin-3. Proc Natl Acad Sci USA 84:2761, 1987
146. Ottmann OG, Ganser A, Seipelt G, Elder M, Schulz G, Hoelzer D: Effects of recombinant human Interleukin-3 on human hematopoietic progenitor and precursor cells in vivo. Blood 76:1494, 1990
147. Vose JM, Kessinger A, Bierman PJ, Sharp G, Garrison L, Armitage JO (Omaha, NE, USA/Seattle, WA, USA): The use of rhIL-3 for mobilization of peripheral blood stem cells in previously treated patients with lymphoid malignancies. Int J of Cell Cloning 10:62, 1992 (suppl 1)
148. Geissler K, Valent P, Mayer P, Liehl E, Hinterberger W, Lechner K, Bettelheim P: Recombinant human interleukin-3 expands the poor of circulating hematopoietic progenitor cells in primates and synergism with recombinant granulocyte/macrophage colony-stimulating factor. Blood 75:2305, 1990
149. Ghielmini M, Pettengell R, Coutinho LH, Testa N, Crowther D: The effect of the GM-CSF/IL-3 fusion protein PIXY 321 on bone marrow and circulating haemopoietic cells of previously untreated patients with cancer. Br J Haematol 93:6, 1996
150. Brasel K, MeKenna HJ, Charrier K, Morrissey P, Williams DE, Lyman SD: Synergistic effects in vivo of flt3 ligand with GM-CSF of G-CSF in mobilization of colony forming cells in mice. Blood 86:499a, 1995 (abstr. suppl 1)
151. Lord BI, Woolford LB, Wood LM, Czaplewski LG, McCourt M, Hunter MG, Edwards RM: Mobilization of early hematopoietic progenitor cells with BB-10010: A genetically engineered variant of human macrophage inflammatory protein-1α. Blood 85:3412, 1995
152. Ganser A, Bergmann M, Völkers B, Grützmacher P, Scigalla P, Hoelzer D: In vivo effects of recombinant human erythropoietin on circulating human hematopoietic progenitor cells. Exp Hematol 17:433, 1989
153. Pettengell R, Woll PJ, Chang J, Coutinho L, Crowther D, Testa NG: Effects of erythropoietin on mobilisation of haemopoietic progenitor cells. Bone Marrow Transplant 14:125, 1994
154. Fibbe WE, Hamilton MS, Laterveer LL, Kibbelaar RE, Falkenburg JH, Visser JW, Willemze R: Sustained engraftment of mice transplanted with IL-1 primed blood-derived stem cells. J Immunol 148:417, 1992
155. Laterveer L, Lindley IJD, Heemskerk DPM, Camps JAJ, Pauwels EKJ, Willemze R, Fibbe WE: Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8. Blood 87:781, 1996
156. Schaafsma MR, Fibbe WE, Van Der Harst D, Duinkerken N, Brand A, Osanto S, Franks CR, Willemze R, Falkenburg JHF: Increased numbers of circulating haematopoietic progenitor cells after treatment with high-dose interleukin-2 in cancer patients. Br J Haematol 76:180, 1990
157. To LB, Haylock DN, Dyson P, Simmons P, Juttner C: Chemotherapy-based approaches to mobilization of progenitor cells, in Morstyn G, Sheridan W (eds): Cell Therapy Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy 9. Cambridge, Cambridge University Press, 1996, p 130
158. Tarella C, Boccardoro M, Omede P, Bondesan P, Caracciolo D, Frierei R, Bregni M, Siena S, Gianni AM, Pileri A: Role of chemotherapy and GM-CSF on hemopoietic progenitor cell mobilization in multiple myeloma. Bone Marrow Transplant 11:271, 1993
159. Chabannon C, Le Coroller A-G, Faucher C, Novakovitch G, Blaise D, Moatti JP, Maraninchi D, Mannoni P: Patient condition affects the collection of peripheral blood progenitors after priming with recombinant granulocyte colony-stimulating factor. J Hematother 4:171, 1995
160. Tricot G, Jagannath S, Vesole D, Nelson J, Tindle S, Miller L, Cheson B, Crowley J, Barlogie B: Peripheral blood stem cell transplants for multiple myeloma: Identification of favorable variables for rapid engraftment in 225 patients. Blood 85:588, 1995
161. Dreger P, Klöss M, Petersen B, Haferlach T, Löffler H, Loeffler M, Schmitz N: Autologous progenitor cell transplantation: Prior exposure to stem cell-toxic drugs determines yield and engraftment of peripheral blood progenitor cell but not of bone marrow grafts. Blood 86:3970, 1995
162. Tarella C, Caracciolo D, Gavarotti P, Bondesan P, Cherasco C, Omedè P, Bregni M, Siena S, Gianni AM, Pileri A: Circulating progenitors following high-dose sequential (HDS) chemotherapy with G-CSF: Short intervals between drug courses severely impair progenitor mobilization. Bone Marrow Transplant 16:223, 1995
163. Fruehauf S, Haas R, Conradt C, Murea S, Witt B, Mohle R, Hunstein W: Peripheral blood progenitor cell (PBPC) counts during steady-state hematopoiesis allow to estimate the yield of mobilized PBPC after filgrastim (R-metHuG-CSF)-supported cytotoxic chemotherapy. Blood 85:2619, 1995
164. Holdrinet RSG, Egmond JV, Wessels JMC, Haaanen C: A method for quantification of peripheral blood mixture in bone marrow aspirates. Exp Hematol 8:103, 1980
165. Parmentier C, Droz P, Tubiana M: Ways of expressing results of human bone marrow progenitor cell culture. Br J Haematol 40:105, 1978
166. Gordon MY, Douglas IDC, Clink HM, Pickering BM: Distribution of granulopoietic activity in the human skeleton, studied by colony growth in agar diffusion chambers. Br J Haematol 32:537, 1976
167. 52iron: Regeneration and extension of marrow after ablative doses of radiotherapy. Cancer 37:1432, 1976
168. Lie AKW, Rawling TP, Bayly JL, To LB: Progenitor cell yield in sequential blood stem cell mobilization in the same patients: Insights into chemotherapy dose escalation and combination of haemopoietic growth factor and chemotherapy. Br J Haematol 95:39, 1996
169. Morley A, Blake J: An animal model of chronic aplastic marrow failure. I. Late marrow failure after busulfan. Blood 44:49, 1974
170. Botnick LE, Hannon EC, Hellman S: Multisystem stem cell failure after apparent recovery from alkylating agents. Cancer Res 38:1942, 1978
171. Bradwein JM, Callum J, Sutcliffe SBV, Scott JG, Keating A: Analysis of factors affecting hematopoietic recovery after autologous bone marrow transplantation for lymphoma. Bone Marrow Transplant 6:291, 1990
172. To LB: Is our current strategy in manipulating hemopoiesis in autologous transplantation correct? Stem Cells 11:283, 1993
173. Moore MAS: Does stem cell exhaustion result from combining hematopoietic growth factors with chemotherapy? If so, how do we prevent it? Blood 80:3, 1992
174. Hillyer CD: Large volume leukapheresis to maximize peripheral blood stem cell collection. J Hematother 2:529, 1993
175. Jones HM, Jones SA, Watts MJ, Khwaja A, Mills W, Fielding A, Goldstone AH, Linch DC: Development of a simplified single leukapheresis approach for peripheral blood progenitor cell transplantation in previously treated patients with lymphoma. J Clin Oncol 12:1693, 1994
176. Siena S, Bregni M, Brando B, Ravagnani F, Bonadonna G, Gianni AM: Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients: Enhancement by intravenous recombinant human granulocyte-macrophage colony-stimulating factor. Blood 74:1905, 1989
177. Wunder E, Solovot H, Fritsch G, Silvestri F, Henon P, Serke S: Report of the European workshop on peripheral blood blood stem celt determination and standardization-Mulhouse, France. J Hematother 1:131, 1992
178. Andrews RG, Singer JW, Bernstein ID: Precursors of colony-forming cells in human can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties. J Exp Med 169:1721, 1992
179. Srour EF, Brandt JE, Leemhuis T, Van Besien K, Hoffman R: Simulaneous use of CD34, Cd15, anti-HLA-DR and rhodamine 123 for the isolation of precursors of human hematopoietic progenitor cells. Exp Hematol 18:549, 1990
180. Lansdorp PM, Sutherland HJ, Eaves CJ: Selsctive expression of CD45 isoforms on functional subpopulations of CD34+ hematopoietic cells from human bone marrow. J Exp Med 172:363, 1990
181. Terstappen LWM, Huang S, Safford M, Lansdorp PM, Loken MR: Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+ CD38-progenitor cells. Blood 77:1218, 1991
182. Bender JG, Unverzagt KL, Walker DE, Lee W, Lum L, Van Epps DE, Stewart CC, To LB: Identification and comparison of CD34+ cells and their subpopulations from normal peripheral blood and bone marrow using multicolor flow cytometry. Blood 77:2591, 1991
183. Bender JG, Williams SF, Myers S, Nottleman D, Lee WJ, Unverzagt KL, Walker D, To LB, Van Epps DE: Characterization of chemotherapy mobilized peripheral blood progenitor cells for use in autologous stem cell transplantation. Bone Marrow Transplant 10:281, 1992
184. Hohaus S, Goldschmidt H, Ehrhardt R, Haas R: Successful autografting following myeloablative conditioning therapy with blood stem cells mobilsed by chemotherapy plus rhG-CSF. Exp Hematol 21:508, 1993
185. Craig W, Kay R, Cutler RL, Lansdorp PM: Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 177:1331, 1993
186. Haas R, Mohle R, Murea S, Goldsmidt H, Pforsich M, Witt M, Hunstein W: Characterisation of peripheral blood progenitor cells mobilised by cytotoxic chemotherapy and recombinant granulocyte colony-stimulating factor. J Hematother 3:323, 1994
187. Murray L, Chen B, Galy A, Chen S, Tushinski R, Uchida N, Negrin R, Tricot G, Jagannath S, Vesole D, Barlogie B, Hoffman R, Tsukomoto A: Enrichment of human hematopoietic stem cell activity in the CD34+Thy-1+ Lin-subpopulation from mobilised peripheral blood. Blood 85:368, 1995
188. Stewart AK, Keating IA, Anania S, Nayar R, Sutherland R: Optimising the CD34+ and CD34+Thy-1+ stem cell content of peripheral blood collections. Exp Hematol 23:1619, 1995
189. Haas R, Mohle R, Pforsich M, Fruehauf S, Witt B, Goldsmidt H, Huntsein W: Blood derived autografts collected during granulocyte colony-stimulating factor-enhanced recovery are enriched with early Thy-1+ hematopoietic progenitor cells. Blood 85:1936, 1995
190. Humeau L, Bardin F, Maroc C, Alario T, Galindo R, Mannoni P, Chabannon C: Phenotypic, molecular and functional characterisation of human peripheral blood CD34+/Thy1 + cells. Blood 87:949, 1996
191. Tong J, Hoffman R, Siena S, Srour S, Bregni EF, Bregni M, Gianni AM: Characterization and quantitation of primitive hematopoietic progenitor cells present in peripheral blood autografts. Exp Hematol 22:1016, 1994
192. Roberts AW, Metcalf D: Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines. Blood 86:1600, 1995
193. Siena S, Bregni M, Bonsi L, Sklenar I, Bagnara GP, Bonadonna G, Gianni AM: Increase in peripheral blood megakaryocyte progenitors following cancer therapy with high-dose cyclophosphamide and hematopoietic growth factors. Exp Hematol 21:1583, 1993
194. Dyson PG, Jackson KA, McClure BJ, Rawling TP, To LB: Increased leels of megakaryocyte progenitors in peripheral blood mobilised by chemotherapy and/or haemopoietic growth factors protocols. Bone Marrow Transplant 18:705, 1996
195. Takamatsu Y, Harada M, Teshima T, Makino S, Inaba S, Akashi K, Shibuya T, Niho Y: Relationship of infused CFU-GM and CFU-Mk mobilised by chemotherapy with or without G-CSF to platelet recovery after autologous blood stem cell transplantation. Exp Hematol 23:8, 1995
196. Galy AHM, Webb S, Cen D, Murray LJ, Condino J, Negrin RS, Chen BP: Generation of T cells from cytokine-mobilised peripheral blood and adult bone marrow CD34+ cells. Blood 84:104, 1994
197. Dooley DC, Law P: Detection and quantitation of long-term culture initiating cells in normal human peripheral blood. Exp Hematol 20:156, 1992
198. Udomsaki C, Lansdorp PM, Hogge DE, Eaves AC, Eaves CJ: Characterisation of primitive hematapoietic cells in normal human peripheral blood. Blood 80:2513, 1992
199. Sutherland HJ, Eaves CJ, Lansdorp PM, Phillips GL, Hogge DE: Kinetics of committed and primitive blood progenitor mobilisation after chemotherapy and growth factor treatment and their use in autotransplants. Blood 83:3808, 1994
200. Tong J, Gianni AM, Siena S, Srour BF, Bregni M, Hoffman R: Primitive hematopoietic progenitor cells are present in peripheral blood autografts. Blood Cells 20:351, 1994
201. Siena S, Bregni M, Di Nicoa M, Ravagani F, Peccatori F, Gandola L, Lombardi F, Tarella C, Bonadonna G, Gianni AM: Durability of hematopoiesis following autografting with peripheral blood hematopoietic progenitors. Ann Oncol 5:935, 1994
202. Silva MRG, Parreira A, Ascensão JL: Natural killer cell numbers and activity in mobilized peripheral blood stem cell grafts: Conditions for in vitro expansion. Exp Hematol 23:1676, 1995
203. Lopez M, Mortel O, Pouillart P, Zucker JM, Fechtenbaum J, Douay L, Palangie T, Michon J, Salmon D, Gorin NC: Acceleration of hemopoietic recovery after autologous bone marrow transplantation by low doses of peripheral blood stem cells. Bone Marrow Transplant 7:173, 1991
204. Takamatsu Y, Akashi K, Harada M, Teshima T, Inaba S, Shimoda K, Eto T, Shibuya T, Okamura S, Niho Y: Cytokine production by peripheral blood monocytes and T cells during haemopoietic recovery after intensive chemotherapy. Br J Haematol 83:21, 1993
205. Testa U, Martucci R, Rutella S, Scambia G, Sica S, Panici B, Pierelli L, Menichella G, Leone G, Mancuso S, Peschle C: Autologous stem cell transplantation: Release of early and late acting growth factors relates with hematopoietic ablation and recovery. Blood 84:3532, 1994
206. Kolb H-J, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D, Van Rhee F, Mittermueller J, deWitte T, Holler E, Ansari H, for the European Group for Blood and Marrow Transplantation Working Party Chronic Leukaemia: Graft-versus-leukaemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 86:2041, 1995
207. Lewis ID, Rawling T, Dyson PG, Haylock DN, Juttner CA, To LB: Standardisation of the CFU-GM Assay Using Hemopoietic Growth Factors. J Hematother 5:625, 1996
208. Siena S, Bregni M, Brando B, Belli N, Landsdorp PM, Bonnadonna G, Gianni M: Flow cytometry to estimate circulating hematopoietic progenitors for autologous transplantation: Comparative analysis of different CD34 monoclonal antibodies. Haematologica 76:330, 1991
209. Bender JG, Unverzagt K: Flow cytometric analysis of peripheral blood stem cells. J Hematother 2:421, 1993
210. Serke S, Huhn D: Quantification of blood CD34-positive cells (letter to the editor). Blood 80:1628, 1992
211. Kressig C, Kirsch A, Serke S: Characterisation and measurement of CD34-expressing hematopoietic cells. J Hematother 3:263, 1994
212. Chen CH, Lin W, Shye S, Kibler R, Grenier K, Recktenwald D, Terstappen LWMM: Automated enumeration of CD34+ cells in peripheral blood and bone marrow. J Hematother 3:3, 1994
213. Sutherland DR, Anderson L, Keeney M, Nayar Chin-Yee I: The ISHAGE guidelines for CD34+ cell determination by flow cytometry. J Hematother 5:213, 1996
214. Sutherland DR: Assessment of peripheral blood stem cell grafts by CD34+ cell enumeration: Toward a standardized flow cytometric approach. J Hematother 5:209, 1996
215. Brecher ME, Sims L, Schmitz J, Shea T, Bentley SA: North American Multicentre study on flow cytometric enumeration of CD34+ hematopoietic stem cells. J Hematother 5:227, 1996
216. Johnsen HE, Knudsen LM, Nordic flow cytometry standards for CD34+ cell enumeration in blood and leukapheresis products: report from the second Nordic workshop. J Hematother 5:237, 1996
217. Juttner CA, To LB, Ho JQK, Thorp DL, Kimber RJ: Successful peripheral blood stein-cell autograft with a near critical dose of myeloid progenitor cells in acute non-lymphoblastic leukaemia in relapse. Med J Aust 147:292, 1987
218. To LB, Haylock DN, Dyson PG, Thorp D, Roberts MM, Juttner CA: An unusual pattern of haemopoietic reconstitution in patients with acute myeloid leukaemia transplanted with autologous recovery phase peripheral blood. Bone Marrow Transplant 6:109, 1990
219. To LB, Haylock DN, Dyson PG, Rawling C, Simmons PJ, Juttner CA: Progenitor threshold effects in haemopoietic reconstitution. Autologous Marrow and Blood Transplantation. 1995 The Cancer Treatment Research and Educational Institute, Arlington, TX, IX:511, 1994
220. Sheridan WP, Begley CG, To LB, Grigg A, Szer J, Maher D, Green MD, Rowlings PA, McGrath KM, Cebon J, Dyson P, Watson D, Bayly J, deLuca E, Tomita D, Hoffman E, Morstyn, Juttner CA: Phase II study of autologous filgrastim (G-CSF)-mobilized peripheral blood progenitor cells to restore hemopoiesis after high-dose chemotherapy for lymphoid malignancies. Bone Marrow Transplant 14:105, 1994
221. Kawana Y, Takaue Y, Watanabe T, Saito S, Hirao A, Abe T, Sato J, Ninomiya T, Shimokawa T, Yokobayashi A, Asana S, Masaoka T, Takaku F, Kuroda Y: Effects of progenitor cell dose and preleukapheresis use of human recombinant granulocyte colony-stimulating factor on the recovery of hematopoiesis after blood stem cell autografting in children. Exp Hematol 21:103, 1993
222. Roberts MM, Dyson PG, Willson K, Juttner CA, To LB: Peripheral blood stem cells mobilized from patients with acute myeloid leukaemia have different platelet roepopulating ability to those mobilised from patients with other diseases. Bone Marrow Transplant 18:41, 1996
223. Schimazaki C, Oku N, Uchiyama H, Yamagata N, Tatsumi T, Hirata T, Ashihara E, Okawa K, Goto H, Inaba T, Fujita N, Haruyama H, Nakagawa M: Effect of granulocyte colony-stimulating factor on haematopoietic recovery after peripheral blood progenitor cell transplantation. Bone Marrow Transplant 13:271, 1994
224. Smith SL, Bender JG, Maples PB, Unverzagt K, Schilling M, Lum L, Williams S, Van Epps DE: Expansion of neutrophil precursors and progenitors in suspension cultures of CD34+ cells enriched from human bone marrow. Exp Haematol 21:870, 1993
225. Haylock DN, Makino S, Dowse TL, Trimboli S, Niutta S, To LB, Juttner CA, Simmons PJ: Ex vivo hematopoietic progenitor cell expansion. Immunomethods 5:217, 1994
226. Schwartz RM, Palsson BO, Emerson SG: Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures. Proc Natl Acad Sci USA 88:6760, 1991
227. Shapiro F, Yao T-J, Raptis G, Reich L, Norton L, Moore MAS: Optimization of conditions for ex-vivo expansion of CD34+ cells from patients with stage IV breast cancer. Blood 84:3567, 1994
228. Williams SF, Lee WJ, Bender JG, Zimmerman T, Swinney P, Blake M, Carreon J, Schilling M, Smith S, Williams DE, Oldham F, Van Epps D: Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer. Blood 87:1687, 1996
229. Brugger W, Heimfeld S, Berenson RJ, Mertelsmann R, Kanz L: Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex-vivo. N Engl J Med 333:283, 1995
230. Beyer J, Schwella N, Zingsem J, Strohscheer I, Sehwaner I, Oettle H, Serke S, Huhn D, Siegert W: Hematopoietic rescue after high-dose chemotherapy using autologous peripheral-blood progenitor cells or bone marrow: A randomized comparison. J Clin Oncol 13:1328, 1995
231. + cells. Cytometry 23:250, 1996
232. Appelbaum FR: Haemopoietic reconstitution following autologous bone marrow and peripheral blood mononuclear cell infusion. Exp Haematol 7:7, 1979 (suppl 5)
233. Henon PR, Liang H, Beck-Wirth G, Eisenmann JC, Lepers M, Wunder E, Kandel G: Comparison of haemopoietic and immune recovery after autologous bone marrow or blood stem cell transplants. Bone Marrow Transplant 9:285, 1992
234. Takaue Y, Okamoto Y, Kawano Y, Suzue T, Abe T, Saito SI, Sato J, Hirao A, Makimoto A, Kawahito M: Regeneration of immunity and varicella-zoster virus infection after high-dose chemotherapy and peripheral blood stem cell autografts in children. Bone Marrow Transplant 14:219, 1994
235. -1 lymphocyte cell enumberation for prediction of clinical course of human immunodeficiency virus disease. J Infect Dis 165:352, 1992
236. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Kathe S, Watanabe M, Thomas ED, Riddell SR: Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333:1038, 1995
237. Scheid C, Pettengell R, Ghielmini M, Radford JA, Morgensteren GR, Stern PL, Crowther D: Time-course of the recovery of cellular immune function after high-dose chemotherapy and peripheral blood progenitor cell transplantation for high-grade non-Hodgkin's lymphoma. Bone Marrow Transplant 15:901, 1995
238. Johnsen HE, Hansen PB, Plesner T, Ralfkiaer E, Hansen NE: Increased yield of myeloid progenitor cells in bone marrow harvested for autologous transplantation by pretreatment with recombinant human granulocyte-colony stimulating factor. Bone Marrow Transplant 10:229, 1992
239. Johnsen HE, Hansen PB, Plesner T, Ralfkiaer E, Hansen NE: Cytokine priming of bone marrow and blood progenitors before harvest for autologous stem-cell transplantation, in Levitt D, Mertelsmann R (eds): Hematopoietic Stem Cells. New York, NY, Dekker, 1995, p 455
240. Janssen WE, Smilee RC, Elfenbein GJ: A prospective randomized trial comparing blood- and marrow-derived stem cells for hematopoietic replacement following high-dose chemotherapy. J Hematother 4:139, 1995
241. Fibbe WE, Heemskerk DPM, Laterveer L, Pruijt JDM, Foster D, Kaushansky K, Willemze R: Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 86:3308, 1995
242. Harousseau JL, Attal M, Divine M, Milpied N, Marit G, Leblond V, Stoppa AM, Bourhis JH, Caillot D, Boasson M, Abgrall JF, Facon T, Colombat P, Cahn JY, Lamy T, Troussard X, Gratecos N, Pignon B, Auzanneau G: Comparision of autologous bone marrow transplantation and peripheral blood stem cell transplantation after first remission induction treatment in multiple myeloma. Bone Marrow Transplant 15:963, 1995
243. Peters WP, Ross M, Vredburgh B, Meisenberg B, Marks L, Winer E, Kurtzberg J, Bast RC, Jones R, Shpall E, Wu K, Rosner G, Gilbert C, Mathias B, Coniglio D, Petros W, Henderson IC, Norton L, Weiss RB, Budman D, Hurd D: High-dose chemotherapy and autologous bone marrow support as consolidation after standarddose adjuvant therapy for high-risk primary breast cancer. J Clin. Oncol 11:1132, 1993
244. Tepler I, Cannistra SA, Frei E: Use of peripheral blood progenitor cells abrogates the myelotoxicity of repetitive outpatient high dose carboplatin and cyclophosphamide chemotherapy. J Clin Oncol 11:1583, 1993
245. Ayash LJ, Elias A, Wheeler C, Reich E, Schwartz G, Mazanet R, Tepler I, Warren D, Lynch C, Gonin R, Schnipper L, Frei E, Antman K: Double dose-intensive chemotherapy with autologous marrow and peripheral-blood progenitor-cell support for metastatic breast cancer. A feasibility study. J Clin Oncol 12:37, 1994
246. Bezwoda WR, Seymour L, Dansey RD: High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: A randomized trial. J Clin Oncol 13:2483, 1995
247. + peripheral blood progenitor cells after high-dose chemotherapy for patients with advanced multiple myeloma. Blood 86:390, 1995
248. Negrin RS, Kusnierz-Glaz, Still BJ, Schriber JR, Nelson JC, Long GD, Hoyle C, Hu WW, Horning SJ, Brown BW, Blume KG, Strober S: Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-hodgkin's lymphoma. Blood 85:3334, 1995
249. Macintyre EA, Belanger C, Debert C, Canioni D, Turhan AG, Azagury M, Hermine O, Varet B, Flandrin G, Schmitt C: Detection of clonal CD34+19+ progenitors in bone marrow of BCL2-IgH-positive follicular lymphoma patients. Blood 86:4691, 1995
250. Campana D, Pui C-H: Detection of minimal residual disease in acute leukemia: Metholdologic advances and clinical significance. Blood 85:1416, 1995
251. Brenner MK, Rill DR, Moen RC, Krance RA, Mirro J, Anderson WF, Ihle JN: Gene-marking to trace origin of relapse after autologous bone marrow transplantation. Lancet 341:85, 1993
252. Gorin NC: Marrow purging: Present status and future perspectives - Efficacy in AML. Prog Clin Biol Res 377:251, 1992
253. Szer J, Juttner CA, To LB, Bradstock KF, Sage RE, Enno A, Toogood IRG: Post-remission therapy for acute myeloid leukaemia with blood-derived stem cell transplantation. Results of a collaborative phase II trial. Int J Cell Cloning 10:114, 1992
254. Brisco MJ, Condon J, Hughes E, Neon SH, Sykes PJ, Seshadri R, Toogood I, Waters K, Tauro G, Ekert H: Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction. Lancet 22:343,196, 1994
255. Seriu T, Yokota S, Nakao M, Misawa S, Takaue Y, Koizumi S, Kawai S, Fujimoto T: Prospective monitoring of minimal residual disease during the course of chemotherapy in patients with acute lymphoblastic leukemia, and detection of contaminating tumor cells in peripheral blood stem cells for autotransplantation. Leukemia 9:615, 1995
256. Sharp JG, Mann SL, Murphy B, Weekes C: Culture methods for the detection of minimal tumour contamination of hematopoietic harvests: A review. J Hematother 4:1418, 1995
257. Craig JL, Langlands K, Parker AC, Anthony RS: Molecular detection of tumor contamination in peripheral blood stem cell harvests. Exp Hematol 22:898, 1994
258. 258: Dreyfus F, Ribrag V, Leblond V, Ravaud P, Melle J, Quarre MC, Pillier C, Boccaccio C, Varet B: Detection of malignant B cells in peripheral blood stem cell collections after chemotherapy in patients with multiple myeloma. Bone Marrow Transplant 15:707, 1995
259. Henry JM, Sykes PJ, Brisco MH, To LB, Juttner CA, Morley AA: Comparison of myeloma cell contamination of bone marrow and peripheral blood stem cell harvests. Br J Haematol 92:614, 1996
260. Simpson SJ, Vachula M, Kennedy MJ, Kaizer H, Coon JS, Williams S, Van Epps D: Detection of tumor cells in the bone marrow, peripheral blood, and apheresis products breast cancer patients using flow cytometry. Exp Hematol 23:1062, 1995
261. Passos-Coelho JL, Ross AA, Moss TJ, Davis JM, Huelskamp A-M, Noga SJ, Davidson NE, Kennedy MJ: Absence of breast cancer cells in a single-day peripheral blood progenitor cell collection after priming with cyclophosphamide and granulocyte-macrophage colony-stimulating factor. Blood 85:1138, 1995
262. Neiderwieser DW, Appelbaum FR, Gastl G, Gersdorf E, Meister B, Geissler D, Tratkiewicz JA, Thaler J, Huber C: Inadvertent trasmission of a donor's acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia. N Engl J Med 322:1794, 1990
263. Brito-Babapulle F, Apperley JF, Rassool F, Guo A-P, Dowding C, Goldman JM: Complete remission after autografting for chronic myeloid leukemia. Leuk Res 11:1115, 1987
264. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 17:367, 645, 1994
265. Henon PR: Antologous blood stem-cell versus bone marrow transplantation: Comparison of cast-ettectiveness and of clinical benefits, in Levitt D, Mertelsmann R (eds): Hematopoietic Stem Cells. New York, NY, Dekker, 1995, p 421
266. Henon P, Donatini B, Eisenmann JC, Becker M, Beck-Wirth G: Comparative survival, quality of life and cost-effectiveness of intensive therapy with autologous blood cell transplantationor conventional chemotherapy in multiple myeloma. Bone Marro Transplant 16:19, 1995
267. Kessinger A, Smith DM, Strandjord SE, Landmark JD, Dooley DC, Law P, Coccia PF, Warkentin PI, Weisenburger DD, Armitage JO: Allogeneic transplantation of blood-derived. T cell-depleted hemopoietic stem cells after myeloablative treatment in a patient with acute lymphoblastic leukemia. Bone Marrow Transplant Nov 4:643, 1989
268. Korbling M, Przepiorka D, Huh Y, Engel H, Van Besien K, Giralt S, Anderson B, Kleine HD, Seong D, Deisseroth AB, Andreef M, Champlin R: Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: Potential advantages of blood over marrow allografts. Blood 86:1659, 1995
269. Ottinger HD, Beelen DW, Scheulen B, Schaefer UW, Grosse-Wilde H: Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow. Blood 88:2775, 1996
270. Reisner Y, Martelli M: Bone marrow transplantation across HLA barriers by increasing the number of transplanted cells. Immunol Today 16:437, 1995
271. Aversa F, Tabilio A, Terenzi A, Velardi A, Falzeth F, Giannoni C, Iacucci R, Zei T, Martelli MP, Gambelunghe C, Rossetti M, Caputo P, Latini P, Aristei C, Raymond C, Reisner Y, Martelli M: Successful engraftment of T-cell depleted haploidentical 'tree loci' incompatible transplantation in leukemia patients by addition of recombinant granulocyte colony-stimulating factor-mobilised peripheral blood progenitor cells to marrow inoculum. Blood 84:3948, 1994
272. Coulombel L, Kalousek DK, Eaves CJ, Gupta CM, Eaves AC: Long term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome positive chronic myelogenous leukemia. N Engl J Med 306:1493, 1983
273. Gronthos S, To LB, Moore S, Suttle JM, Juttner CA: The detection of Philadelphia chromosome negative metaphases in long term bone marrow cultures of the peripheral blood from patients with chronic myeloid leukemia predicts response to interferon-alpha 2a. Leukemia 6:1246, 1992
274. Carella AM, Pollicardo N, Raffo MR, Podesta M, Carlier P, Valbonesi M, Lercari G, Vitale V, Gallamini A: Intensive conventional chemotherapy can lead to a precocious overshoot of cytogenetically normal blood stein cells (BSC) in chronic myeloid leukemia and acute lymphoblastic leukemia. Leukemia 6:120, 1992 (suppl 4)
275. Verfaillie CM, Miller WJ, Boylan K, McGlave PB: Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression. Blood 79:1003, 1992
276. Berardi AC, Wang A, Levine JD, Lupez P, Scadden DT: Functinal isolation and characterisation of human hematopoietic stem cells. Science 267:104, 1995
277. Dunbar CE, Stewart FM: Separating the wheat from the chaff: Selection of benign hematopoietic cells in chronic myeloid leukemia. Blood 79:1107, 1992
278. Leopold LH, Shore SK, Newkirk TA, Reddy RMV, Reddy EP: Multi-unit ribozyme-mediated cleavage of bcr-abl mRNA in myeloid leukemias. Blood 85:2162, 1995
279. de Fabritis P, Amadori S, Petti MC, Mancini M, Montefusco E, Picardi A, Geiser T, Campbell K, Calabretta B, Mandelli F: In vitro purging with BCR-ABL antisense oligodeoxynucleotides does not prevent hematologic reconstitution after autologous bone marrow transplantation. Leukemia 9:662, 1995
280. Delforge M, Demuynck H, Vandenber;ghe P, Verhoef G, Zachee P, Van Duppen V, Marijnen P, Van den Berghe H, Boogaerts MA: Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes. Blood 86:3660, 1995
281. Takaue Y, Kawano Y, Abe T, Okamoto Y, Suzue T, Shimizu T, Saito S, Sato J, Makimoto A, Nakagawa R: Collection and transplantation of peripheral blood stem cells in very small children weighing 20 kg or less. Blood 86:372, 1995
282. Takaue Y, Watanabe T, Kawano Y, Koyama T, Huq AHM, Ninomiya T, Kuroda Y: Sustained cytopenia in small children after leukapheresis for collection of peripheral blood stem cells. Vox Sang 57:168, 1989
283. - hematopoietic precursors in paroxysmal nocturnal hemoglobinuria. Blood 86:3381, 1995
284. Burt RK, Burns W, Hess A: Bone marrow transplantation for multiple sclerosis. Bone Marrow Transplant 16:1, 1995
285. Dunbar CE: Clinical gene therapy, in Morstyn G, Sheridan W (eds): Cell Therapy Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy (vol 21). New York, NY, Cambridge University Press, 1996, p 369
286. Kohn DB, Weinberg KI, Nolta JA, Heiss LN, Lenarsky C, Crooks GM, Hanley ME, Annett G, Brooks JS, el-Khoureiy A: Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nat Med 1:1017, 1995
287. Hanania EG, Kavanagh J, Hortobagyi G, Giles RE, Champlin R, Deisseroth AB: Recent advances in the application of gene therapy to human disease. Am J Med 99:537, 1995
288. + peripheral blood progenitor cells I of a mutated dihydrofolate reductase cDNA via retroviral gene transfer. Blood 85:556, 1995
289. Malech HL, Sekhsaria S, Whiting-Theobald, Linton GF, Vowells LF, Miller JA, Holland SM, Leitman SF, Carter CS, Read EJ, Butz R, Wannebo C, Fleisher TA, Deans RJ, Spratt SK, Maack CA, Rokovich JA, Cohen LK, Maples Gallin JI: Development of a phase I clinical trial of gene therapy for chronic granulomatous disease. Blood 85:295a, 1995 (abstr, suppl 1)
290. Nimgaonkar M, Mierski J, Beeler M, Kemp A, Lancia J, Mannion-Henderson J, Mohney T, Bahnson A, Rice E, Ball ED, Barranger JA: Cytokine mobilization of peripheral blood stem cells in patients with gaucher disease with a view to gene therapy. Exp Hematol 23:1633, 1995