Type I protein kinase A is localized to interphase microtubules and strongly associated with the mitotic spindle

Experimental Cell Research

Volumn 264, Issue 2, 2001, Pages 250-265

  Imaizumi Scherrer, Tereza ^a   Faust, Daniela M ^a   Barradeau, Sébastien ^a   Hellio, Raymond ^b   Weiss, Mary C ^a  

^a URA du CNRS 1773   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

cAMP dependent PKA; Cell cycle; Hepatoma; Mutant RI

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CELL CYCLE; CENTROSOME; CONTROLLED STUDY; CYTOKINESIS; GIANT CELL; HUMAN; INTERPHASE; LIVER CELL CARCINOMA; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SISTER CHROMATID;

EID: 0035298062     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5164     Document Type: Article

References (67)

1. Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches
2. Compensatory regulation of RIα protein levels in protein kinase A mutant mice
3. Nucleotide-binding sites and structural domains of cAMP-dependent protein kinases
4. PKA isoforms, neural pathways, and behaviour: Making the connection
5. A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP
6. Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification of side chain determinants for anchoring and isoform selective association with AKAPs
7. Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area
8. Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA
9. AKAPs: From structure to function
10. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits
11. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
12. Tayloring cAMP-signalling responses through isoform multiplicity
13. Cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase of human erythrocyte membranes
14. Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
15. Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic sub-units RIα and Cα
16. 2+ channel activity by cAMP-dependent protein kinase
17. The mitotic machinery as a source of genetic instability in cancer
18. A mouse hepatoma cell line which secretes several serum proteins including albumin and α-foetoprotein
19. Spontaneous apoptosis in a rat hepatoma cell line its inhibition by dexamethasone
20. Long-term cultivation of hypodiploid human tumor cells
21. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
22. Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit
23. Intracompartmental sorting of essential myosin light chains: Molecular dissection and in vivo monitoring by epitope tagging
24. Alternative 5′-exons of the mouse cAMP-dependent protein kinase subunit RIα gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion
25. Transfection of DNA into eukaryotic cells
26. Visualization of prosomes (MCP-proteasomes), intermediate filament and actin networks by "instantaneous fixation" preserving the cytoskeleton
27. Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins
28. The pool of MAP kinase associated with microtubules is small but constitutively active
29. The mitotic spindle of chinese hamster ovary cells isolated in taxol-containing medium
30. Immunofluorescence analysis of the time course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids
31. Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment
32. Expression and characterization of mutant forms of the type I regulatory subunit of cAMP-dependent protein kinase. The effect of defective cAMP binding on holoenzyme activation
33. Role of cAMP-dependent protein phosphorylation in microtubule assembly and function
34. Mitosis-specific phosphorylation and subcellular redistribution of RIIα regulatory subunit of cAMP-dependent protein kinase
35. Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand stoichiometry and competition
36. Purification of brain microtubules and microtubule-associated protein 1 using taxol
37. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis
38. A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs)
39. A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2)
40. Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau
41. cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics
42. The Xenopus XMAP215 and its homolog TOG proteins interact with cyclin B1 to target p34cdc2 to microtubules during mitosis
43. A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle
44. Roles of motor proteins in building microtubule-based structures: A basic principle on cellular design
45. Microtubule polymerization dynamics
46. Balanced regulation of microtubule dynamics during the cell cycle: A contemporary view
47. Microtubules and signal transduction
48. Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
49. Polo-like kinases: A team that plays throughout mitosis
50. Role of citron kinase as a target of the small GTPase Rho in cytokinesis
51. The stathmin phosphoprotein family: Intracellular localization and effects on the microtubule network
52. A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells
53. Association of mitogen-activated protein kinase with the microtubule cytoskeleton
54. Possible role of the multi catalytic proteinase (proteasome) in regulating the cell cycle
55. The aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis
56. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
57. Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin
58. Control of the microtubule dynamics by oncoprotein 18: Dissection of the regulatory role of multisite phosphorylation during mitosis
59. Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells
60. Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamics
61. Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells
62. Regulation of APC activity by phosphorylation and regulatory factors
63. Whose end is destruction: Cell division and the anaphase-promoting complex
64. Protein kinase A-directed antisense restrains cancer growth: Sequence-specific inhibition of gene expression
65. Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo
66. A developmental timer that regulates apoptosis at the onset of gastrulation