Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1

Biochemical and Biophysical Research Communications

Volumn 292, Issue 4, 2002, Pages 841-847

  Schnyder, Bruno ^a   Schnyder Candrian, Silvia ^a   Moser, René ^a   Panski, Andreas ^b   Heim, Markus ^b   Bömmel, Heike ^c   Duschl, Albert ^c  

^a Institute for Biopharmaceutical Research Inc   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF SALZBURG   (Austria)

Author keywords

B cells; Endothelium; Histamine; IL 4; Sesquiterpene lactone; Stat6; TNF; VCAM 1

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; LUCIFERASE; PARTHENOLIDE; STAT6 PROTEIN; TYROSINE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG EFFECT; ENDOTHELIUM CELL; EXTRAVASATION; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEUKOCYTE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION;

EID: 0036290162     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6754     Document Type: Article

References (22)

1. Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions
2. Sesquiterpene lactones specifically inhibit activation of NF-kappaB by preventing the degradation of IkappaB-alpha and IkappaB-beta
3. Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family
4. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB
5. Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells
6. Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain
7. Distribution pattern of tenascin-C in normal and neoplastic mesenchymal tissues
8. Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease
9. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro
10. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappaB by targeting the IkappaB kinase complex
11. Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1
12. Upregulation and activation of Stat6 precede vascular smooth muscle cell proliferation in carotid artery injury model
13. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice
14. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion
15. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
16. Oxidative stress and nuclear factor-kappaB activation: A reassessment of the evidence in the light of recent discoveries
17. The green tea extract epigallocatechin gallate is able to reduce neutrophil transmigration through monolayers of endothelial cells
18. The antiinflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
19. Stat6 inhibits human interleukin-4 promoter activity in T cells
20. Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction
21. Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells
22. Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB