Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 5, 2000, Pages 796-805

  Abendschein, Dana R ^a   Baum, Pamela K ^a   Martin, Daniel J ^a   Vergona, Ron ^b   Post, Joseph ^b   Rumennik, Galina ^b   Sullivan, Mark E ^b   Eisenberg, Paul R ^a   Light, David R ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER AG   (Germany)

Author keywords

Anticoagulants; Factor Xa; Thrombosis

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; ARDEPARIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CENTAXARIN; N [2 (5 AMIDINO 2 HYDROXYPHENOXY) 3,5 DIFLUORO 6 [3 (1 METHYL 1H 2 IMIDAZOLIN 2 YL)PHENOXY] 4 PYRIDINYL] N METHYLGLYCINE; RECOMBINANT TICK ANTICOAGULANT PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; HEMOSTASIS; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RABBIT; THROMBOSIS; VEIN THROMBOSIS;

AMIDINES; ANIMALS; ANTICOAGULANTS; ANTITHROMBIN III; CORONARY THROMBOSIS; DISEASE MODELS, ANIMAL; FEMALE; MALE; NAPHTHALENES; PEPTIDES; PROPIONIC ACIDS; PYRIDINES; RABBITS; SPECIES SPECIFICITY; VENOUS THROMBOSIS;

EID: 0034021684     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200005000-00018     Document Type: Article

References (5)

1. Eisenberg PR, Siegel JE, Abendschein DR, Miletich JP. Importance of factor Xa in determining the procoagulant activity of whole-blood clots. J Clin Invest 1993;91:1877-83.
2. Prager NA, Abendschein DR, McKenzie CR, Eisenberg PR. Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots. Circulation 1995;92:962-7.
3. McKenzie CR, Abendschein DR, Eisenberg PR. Sustained inhibition of whole-blood clot procoagulant activity by inhibition of thrombus-associated factor Xa. Arterioscler Thromb Vasc Biol 1996;16:1285-91.
4. Granger CG, Miller JM, Bovill EG, et al. Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes. Circulation 1995;91:1929-35.
5. Abendschein DR, Meng YY, Torr-Brown S, Sobel BE. Maintenance of coronary patency after fibrinolysis with tissue factor pathway inhibitor. Circulation 1995;92:944-9.