Matrix metalloproteinases: Promoters of tumor progression and invasiveness

Israel Medical Association Journal

Volumn 4, Issue 4, 2002, Pages 280-282

  Sela, Ben Ami ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

Extracellular matrix; Matrix metalloproteinases; Thyroid cancer

Indexed keywords

ADENOVIRUS VECTOR; ANGIOSTATIN; ANTISENSE OLIGONUCLEOTIDE; BB 3103; CHELATING AGENT; DECAPEPTIDE; FURIN; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; PROTEOGLYCAN; PYRIMIDINE 2,4,6 TRIONE; STROMELYSIN; STROMELYSIN 3; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRYPSIN INHIBITOR; TUMOR PROMOTER; UNCLASSIFIED DRUG;

ANGIOGENESIS; BLADDER CANCER; BREAST CANCER; CANCER CELL; CANCER DIAGNOSIS; CANCER GROWTH; CANCER INVASION; CLINICAL TRIAL; COLORECTAL CANCER; DRUG MECHANISM; EDITORIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IN VIVO STUDY; METASTASIS; NONHUMAN; OVARY CANCER; PHAGE DISPLAY; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SKIN CANCER; THYROID CANCER; THYROID PAPILLARY CARCINOMA;

DIAGNOSIS, DIFFERENTIAL; EXTRACELLULAR MATRIX; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; THYROID NEOPLASMS;

EID: 0036278749     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (30)

1. Assay of matrix metalloproteinases types 1, 2, 3 and 9 in breast cancer
2. Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy
3. Serum matrix metalloproteinase-2 and its density in men with prostate cancer as a new predictor of disease extension
4. Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas
5. Increased expression of matrix metalloproteinases (MMP-2), MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer
6. Excretion of matrix metalloproteinases 2 and 9 in urine is associated with a high stage and grade of bladder carcinoma
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13. Distribution of the 72-kD type IV collagenase in noneoplastic and neoplastic thyroid tissue
14. Enhanced production and activation of progelatinase A mediated by membrane type 1 matrix metalloproteinase in human papillary thyroid carcinomas
15. Protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroid carcinomas
16. Tissue inhibitor of metalloproteinases-1 (TIMP-1) mRNA is elevated in advanced stages of thyroid carcinoma
17. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis
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29. Tumor targeting with a selective gelatinase inhibitor
30. Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells