Mutational analysis of Plasmodium falciparum dihydrofolate reductase: The role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding

Molecular and Biochemical Parasitology

Volumn 121, Issue 2, 2002, Pages 185-193

  Sirawaraporn, Worachart ^a   Sirawaraporn, Rachada ^a   Yongkiettrakul, Suganya ^b   Anuwatwora, Amornpol ^b   Rastelli, Guilio ^c   Kamchonwongpaisan, Sumalee ^b   Yuthavong, Yongyuth ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Active site residues; Dihydrofolate reductase; Mutation; Plasmodium falciparum

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ASPARTIC ACID; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; FOLIC ACID ANTAGONIST; PHENYLALANINE; PYRIMETHAMINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BINDING; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; GENE MUTATION; KINETICS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ASPARTIC ACID; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; DNA MUTATIONAL ANALYSIS; FOLIC ACID ANTAGONISTS; KINETICS; MODELS, MOLECULAR; MUTATION; PHENYLALANINE; PLASMODIUM FALCIPARUM; TETRAHYDROFOLATE DEHYDROGENASE;

PLASMODIUM FALCIPARUM;

EID: 0036277069     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00035-X     Document Type: Article

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