Transcriptional downregulation of ORF50/Rta by methotrexate inhibits the switch of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 from latency to lytic replication

Journal of Virology

Volumn 76, Issue 10, 2002, Pages 5208-5219

  Curreli, Francesca ^a   Cerimele, Francesca ^a   Muralidhar, Sumitra ^a   Rosenthal, Leonard J ^a   Cesarman, Ethel ^a   Friedman Kien, Alvin E ^a   Flore, Ornella ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; FOSCARNET; G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 6; KAPOSIN; METHOTREXATE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARCINOGENESIS; CELL LINE; CONTROLLED STUDY; DNA REPLICATION; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN HERPESVIRUS 8; IMMEDIATE EARLY GENE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; VIRUS LATENCY; VIRUS REPLICATION; VIRUS TRANSCRIPTION; VIRUS TRANSFORMATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIVIRAL AGENTS; CYTOSINE; DOWN-REGULATION; DRUG RESISTANCE; FOSCARNET; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERLEUKIN-6; METHOTREXATE; NEUROPEPTIDES; NUCLEIC ACID SYNTHESIS INHIBITORS; OPEN READING FRAMES; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VIRAL PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0036233351     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.10.5208-5219.2002     Document Type: Article

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