Endostatin binds to blood vessels in situ independent of heparan sulfate and does not compete for fibroblast growth factor-2 binding

American Journal of Pathology

Volumn 155, Issue 1, 1999, Pages 71-76

  Chang, Zhen ^a   Choon, Aung ^a   Friedl, Andreas ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ENDOSTATIN; FIBROBLAST GROWTH FACTOR 2; HEPARAN SULFATE;

ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; BINDING AFFINITY; BINDING SITE; BREAST CARCINOMA; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TUMOR GROWTH;

EID: 0033022469     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65101-2     Document Type: Article

References (20)

1. Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364
2. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997, 88:277-285
3. Boehm T, Folkman J, Browder T, O'Reilly MS: Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997, 390:404-407
4. Standker L, Schrader M, Kanse SM, Jurgens M, Forssmann WG, Preissner KT: Isolation and characterization of the circulating form of human endostatin. FEBS Lett 1997, 420:129-133
5. Sasaki T, Fukai N, Mann K, Goehring W, Olsen BR, Timpl R: Structure, function, and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. EMBO J 1998, 17:4249-4256
6. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994, 79:315-328
7. Hohenester E, Sasaki T, Olsen BR, Timpl R: Crystal structure of the angiogenesis inhibitor endostatin at 1.5 angstrom resolution. EMBO J 1998, 17:1656-1664
8. Rapraeger AC, Krufka A, Olwin BB: Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 1991, 252:1705-1708
9. Gitay-Goren H, Soker S, Vlodavsky I, Neufeld G: The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. J Biol Chem 1992, 267:6093-6098
10. Friedl A, Chang Z, Tierney A, Rapraeger AC: Differential binding of FGF-2 and FGF-7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues. Am J Pathol 1997, 150:1443-1455
11. Noonan DM, Fulle A, Valente P, Cai S, Horigan E, Sasaki M, Yamada Y, Hassell JR: The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. J Biol Chem 1991, 266:22939-22947
12. Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV: Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan): a chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. J Biol Chem 1992, 267:8544-8557
13. Rehn M, Pihlajaniemi T: Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins. J Biol Chem 1995, 270:4705-4711
14. Engels K, Fox SB, Whitehouse RM, Gatter KC, Harris AL: Distinct angiogenic patterns are associated with high-grade in situ ductal carcinomas of the breast. J Pathol 1997, 181:207-212
15. Guidi AJ, Fischer L, Harris JR, Schnitt SJ: Microvessel density and distribution in ductal carcinoma in situ of the breast. J Natl Cancer Inst 1994, 86:614-619
16. Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N Engl J Med 1991, 324:1-8
17. Timpl R, Brown JC: Supramolecular assembly of basement membranes. Bioessays 1996, 18:123-132
18. Claesson-Welsh L, Welsh M, Ito N, Anand-Apte B, Soker S, Zetter B, O'Reilly M, Folkman J: Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc Natl Acad Sci USA 1998, 95:5579-5583
19. Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC: Zinc-dependent dimers observed in crystals of human endostatin. Proc Natl Acad Sci USA 1998, 95:10443-10448
20. Boehm T, Oreilly MS, Keough K, Shiloach J, Shapiro R, Folkman J: Zinc-binding of endostatin is essential for its antiangiogenic activity. Biochem Biophys Res Commun 1998, 252:190-194