GABA(A) receptors mediate inhibition of T cell responses

Journal of Neuroimmunology

Volumn 96, Issue 1, 1999, Pages 21-28

  Tian, Jide ^a   Chau, Cindy ^a   Hales, Tim G ^b   Kaufman, Daniel L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Cytokine; DTH; GABA; GABA receptor; Lymphocytes; T cell proliferation

Indexed keywords

3ALPHA HYDROXY 16 IMINO 5BETA 17 AZAANDROSTAN 11 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; BACLOFEN; BICUCULLINE; CYTOKINE; INTERLEUKIN 2; MUSCIMOL; PENTOBARBITAL; PICROTOXIN; VIGABATRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FEMALE; GABAERGIC SYSTEM; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMIDINES; ANIMALS; ANTIGENS, CD3; AUTOCRINE COMMUNICATION; BICUCULLINE; CELL DIVISION; ENZYME INHIBITORS; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HYPERSENSITIVITY, DELAYED; IMMUNOSUPPRESSION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED NOD; MUSCIMOL; PENTOBARBITAL; PICROTOXIN; RECEPTORS, GABA-A; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; VIGABATRIN;

EID: 0033119044     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00264-1     Document Type: Article

References (35)

1. Alberola-Ila J., Takaki S., Kerner J.D., Perlmutter R.M. Differential signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 15:1997;125-154.
2. Atkinson M.A., Bowman M.A., Campbell L., Darrow B.L., Kaufman D.L., Maclaren N.K. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94:1994;2125-2129.
3. Berget et al., 1998. Medicine and Pharmacotherapy 52, 214-219.
4. B receptor pharmacology. Annu. Rev. Pharmacol. Toxicol. 33:1993;109-147.
5. Cabaniols J.P., Cibotti R., Kourilsky P., Kosmatopoulos K., Kanellopoulos J.M. Dose-dependent T cell tolerance to an immunodominant self peptide. Eur. J. Immunol. 24:1994;1743-1749.
6. Cahalan M.D., Lewis R.S. Regulation of chloride channels in lymphocytes. Current Topics in Membranes. 42:1994;103-129.
7. Cooper, J.R., Bloom, F.E., Roth, R.H., 1986. The Biochemical Basis of Neuropharmacology, 5th edn. Oxford, England, Oxford University Press.
8. Deng H., Apple R., Clare-Salzler M., Trembleau S., Mathis D., Adorini L., Sercarz E. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 178:1993;1675-1680.
9. Erdo S.L., Wolff J.R. Gamma-aminobutyric acid outside the mammalian brain. J. Neurochem. 54:1990;363-372.
10. Erlander M.G., Tillakaratne N.J., Feldblum S., Patel N., Tobin A.J. Two genes encode distinct glutamate decarboxylases. Neuron. 7:1991;91-100.
11. Felber S.M., Brand M.D. Factors determining the plasma-membrane potential of lymphocytes. Biochem. J. 204:1982;577-585.
12. Frangulyan, L.A., Manukyan, R.A., Babayab, N.P., Danelyan, G.T., Bagdasaryan, G.H., Armenyan, N.M. (1986). Influence of neuroactive amino acids on some indexes of natural immunity. In: Neurohumoral Regulation of Immune Homeostasis. Leningrad, Russia.
13. Isaacson J.S., Solis J.M., Nicoll R.A. Local and diffuse synaptic actions of GABA in the hippocampus. Neuron. 10:1993;165-175.
14. Ishida Y., Chused T.M. Lack of voltage sensitive potassium channels and generation of membrane potential by sodium potassium ATPase in murine T lymphocytes. J. Immunol. 151:1993;610-620.
15. Jain J., Loh C., Rao A. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:1995;333-342.
16. Janeway C.A. Jr., Bottomly K. Signals and signs for lymphocyte responses. Cell. 76:1994;275-285.
17. Kaufman D.L., Clare-Salzler M., Tian J., Forsthuber T., Ting G.S., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 366:1993;69-72.
18. Kaufman D.L., Tobin A.J. Glutamate decarboxylases and autoimmunity in insulin-dependent diabetes. Trends Pharmacol. Sci. 14:1993;107-109.
19. Lewis R.S., Cahalan M.D. Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13:1995;623-653.
20. A, or glycine receptor. J. Appl. Physiol. 74:1993;1265-1273.
21. A/benzodiazepine receptor heterogeneity: neurophysiological implications. Neuropharmacology. 34:1995;245-254.
22. A receptor channels. Annu. Rev. Neurosci. 17:1994;569-602.
23. Mody I., De Koninck Y., Otis T.S., Soltesz I. Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 17:1994;517-525.
24. Moudgil K.D., Sercarz E.E. Dominant determinants in hen egg white lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J. Exp. Med. 178:1993;2131-2138.
25. Neal M.J., Shah M.A. Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina. Br. J. Pharmacol. 100:1990;324-328.
26. Nio D.A., Moylan R.N., Roche J.K. Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements. J. Immunol. 150:1993;5281-5288.
27. A receptors. FASEB J. 4:1990;1469-1480.
28. Parola A.L., Yamamura H.I., Laird H.E.d. Peripheral-type benzodiazepine receptors. Life Sci. 52:1993;1329-1342.
29. Paul W.E., Seder R.A. Lymphocyte responses and cytokines. Cell. 76:1994;241-251.
30. Ramseier H., Lichtensteiger W., Schlumpf M. In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression. Immunopharmacol. Immunotoxicol. 15:1993;557-582.
31. Ratnikov V.I., Riabinina N.E., Ostrovskaia R.U. Effect of GABA-ergic substances on humoral immunity. Biull. Eksp. Biol. Med. 94:1982;56-58.
32. A-receptor chloride channels. Nature. 341:1989;233-236.
33. Schlumpf M., Lichtensteiger W., Ramseier H. Diazepam treatment of pregnant rats differentially affects interleukin-1 and interleukin-2 secretion in their offspring during different phases of postnatal development. Pharmacol. Toxicol. 73:1993;335-340.
34. Torcia M., Bracci-Laudiero L., Lucibello M., Nencioni L., Labardi D., Rubartelli A., Cozzolino F., Aloe L., Garaci E. Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell. 85:1996;345-356.
35. Wan Q., Xiong Z.G., Man H.Y., Ackerley C.A., Braunton J., Lu W.Y., Becker L.E., MacDonald J.F., Wang Y.T. Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin. Nature. 388:1997;686-690.