In vivo activation of melanoma-specific CD8+ T cells by endogenous tumor antigen and peptide vaccines. A comparison to virus-specific T cells

European Journal of Immunology

Volumn 32, Issue 3, 2002, Pages 731-741

  Speiser, Daniel E ^a,c   Liénard, Danielle ^a   Pittet, Mikaël J ^a   Batard, Pascal ^a   Rimoldi, Donata ^b   Guillaume, Philippe ^b   Cerottini, Jean Charles ^a,b   Romero, Pedro ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c Hopital Orthopedique de la Suisse Romande   (Switzerland)

Author keywords

CD8+ T lymphocyte; Peptide vaccine; T cell differentiation; Tumor antigen; Viral antigen

Indexed keywords

ADJUVANT; ALPHA INTERFERON; CD2 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOKINE; MATRIX PROTEIN; MELAN A; SYNTHETIC PEPTIDE; TETRAMER; TUMOR ANTIGEN; VACCINE; VIRUS ENZYME; VIRUS PROTEIN;

ADVANCED CANCER; ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL SPECIFICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG EFFICACY; EFFECTOR CELL; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MELANOMA; MEMORY CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, NEOPLASM; ANTIGENS, VIRAL; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOMEGALOVIRUS; HLA-A2 ANTIGEN; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOTHERAPY; INFLUENZA A VIRUS; LYMPHOCYTE ACTIVATION; MANNITOL; MELANOMA; NEOPLASM PROTEINS; OLEIC ACIDS; PEPTIDE FRAGMENTS; VACCINES, SUBUNIT; VIRAL MATRIX PROTEINS;

EID: 0036206464     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200203)32:3<731::AID-IMMU731>3.0.CO;2-H     Document Type: Article

References (31)

1. Cellular localization of latent murine cytomegalovirus
2. Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes. Implications of a novel approach for T cell monitoring in infectious and malignant diseases
3. The immunogenicity of human and murine cytomegaloviruses
4. High frequency of cytomegalovirus-specific cytotoxic T-effector cells in HLA-A*0201-positive subjects during multiple viral coinfections
5. Cytotoxic T lymphocytes specific for Influenza virus
6. Phenotypic analysis of antigen-specific T lymphocytes
7. + T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2
8. Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: Human CD8 memory CTLp selectively express CD45RO (UCHL1)
9. + T cell memory, CD45R subsets and the persistence of antigen - A unifying concept
10. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
11. CD28-T lymphocytes. Antigenic and functional properties
12. + T cells
13. Skewed maturation of memory HIV-specific CD8 T lymphocytes
14. + cytotoxic T cells express CD38 and HLA-DR antigens
15. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
16. + effector αβ T cells
17. A shift in the phenotype of Melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response
18. + T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells
19. Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide
20. + T cells during the primary immune response to Epstein-Barr virus in vivo
21. Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues
22. Antiviral immunity
23. Rapid generation of broad T cell immunity in humans after a single injection of mature dendritic cells
24. Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression
25. + melanoma patients by mature monocyte-derived dendritic cells
26. Tumor-specific immune response: Current in vitro analyses may not reflect the in vivo immune status
27. Self antigens expressed by solid tumors do not stimulate naive or activated T cells: Implications for immunotherapy
28. + T cell memory: Relationships between epitope specificity, cell phenotype, and immediate effector function
29. Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness
30. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo
31. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytotoxic T lymphocytes