Ex vivo IFN-γ secretion by circulating CD8 T lymphocytes: Implications of a novel approach for T cell monitoring in infectious and malignant diseases

Journal of Immunology

Volumn 166, Issue 12, 2001, Pages 7634-7640

  Pittet, M J ^a   Zippelius, A ^a   Speiser, D E ^a   Assenmacher, M ^a   Guillaume, P ^a   Valmori, D ^a   Lienard D ^a   Lejeune, F ^a   Cerottini, J C ^a   Romero, P ^a  

^a Hopital Orthopedique de la Suisse Romande   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MELAN A; TETRAMER;

ANTIGEN DETECTION; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CANCER; CELL HETEROGENEITY; CELL SECRETION; CELL SELECTION; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALIC INCLUSION BODY DISEASE; DISEASE ASSOCIATION; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFECTION; INFLUENZA; LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MELANOMA; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035876923     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.12.7634     Document Type: Article

References (37)

1. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
2. Functions of CD8 T-cell subsets secreting different cytokine patterns
3. Reverse ELISPOT assay for clonal analysis of cytokine production. I. Enumeration of gamma-interferon-secreting cells
4. + T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals
5. Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses
6. Quantitation of antigen-reactive T cells in peripheral blood by IFNγ-ELISPOT assay and chromium-release assay: A four-centre comparative trial
7. + T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
8. Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression
9. Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix
10. + T cells based on cytokine secretion
11. + antigen-specific cytotoxic T lymphocytes after enrichment based on cytokine secretion: Comparison with the MHC-tetramer technology
12. Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell
13. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release γ interferon, tumor necrosis factor α (TNF-α), and TNF-β when they encounter their target antigens
14. Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues
15. + T cells produce antiviral cytokines but are impaired in cytolytic function
16. Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression
17. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
18. + T cells following vaccination with antigenic peptide
19. Partial purification and some properties of BB7.2: A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28
20. Phenotypic analysis of antigen-specific T lymphocytes
21. Ex vivo staining of metastatic lymph nodes by class 1 major histocompatibility complex tetramers reveals high numbers of antigen- experienced tumor-specific cytolytic T lymphocytes
22. Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues
23. Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the Vβ 17 gene segment
24. + virus-specific cytotoxic T lymphocytes
25. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
26. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
27. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
28. + T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells
29. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
30. Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: Human CD8 memory CTLp selectively express CD45RO (UCHL1)
31. bright T cell subsets and their relationship to memory and naive T cells
32. + T-cell memory, CD45R subsets and the persistence of antigen: A unifying concept
33. A shift in the phenotype of Melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response
34. + T cells
35. CD28- T lymphocytes. Antigenic and functional properties
36. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection
37. + T cells