Transgenic expression of interleukin 10 in the pancreas renders resistant mice susceptible to low dose streptozotocin-induced diabetes

Journal of Autoimmunity

Volumn 9, Issue 2, 1996, Pages 151-158

  Mueller, Regula ^a   Lee, Myung Shik ^a   Sawyer, Stephen P ^a   Sarvetnick, Nora ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Diabetes mellitus; IL 10; Insulitis; Streptozotocin

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE EXPRESSION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENE;

EID: 0029956260     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0018     Document Type: Article

References (41)

1. Honeyman M.C., Harrison L.C. 1993. The immunological insult in type 1 diabetes. Springer Semin. Immunopathol. 14: 253-274
2. Foulis A.K., McGill M., Farquharson M.A. 1991. Insulitis in type I (insulin-dependent) diabetes mellitus in man-macrophages, lymphocytes and interferon-γ containing cells. J. Pathol. 165: 97-103
3. Sibley R.K., Sutherland D.E.R., Goetz F., Michael A.F. 1985. Recurrent diabetes mellitus in the pancreas isoand allograft. Laboratory Investigations 53: 132-136
4. Paik S.-G., Fleischer N., Shin S.-I. 1980. Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: Obligatory role of cell-mediated autoimmune processes. Proc. Natl. Acad. Sci. USA 77: 6129-6133
5. Kim Y.T., Steinberg C. 1984. Immunologic studies on the induction of diabetes in experimental animals. Cellular basis for the induction of diabetes by streptozotocin. Diabetes 33: 771-777
6. Kiesel U., Freytag G., Biener J., Kolb H. 1980. Transfer of experimental autoimmune insulitis by spleen cells in mice. Diabetologia 19: 516-520
7. Herold K.C., Montag A.G., Fitch F.W. 1987. Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin. Diabetes 36: 796-801
8. Wilson G.L., Leiter E.H. 1990. Streptozotocin interactions with pancreatic β cells and the induction of insulin-dependent diabetes. Current Topics in Microbiology and Immunology 156: 27-54
9. Rossini A.A., Appel M.C., Williams R.M., Like A.A. 1977. Genetic influence of the streptozotocin-induced insulitis and hyperglycemia. Diabetes 26: 916-920
10. Like A.A., Rossini A.A. 1976. Streptozotocin-induced pancreatic insulitis: New model of diabetes. Science 193: 415-417
11. Rossini A.A., Williams R.M., Appel M.C., Like A.A. 1978. Complete protection from low-dose streptozotocin-induced diabetes in mice. Nature 276: 182-184
12. Kantwerk G., Cobbold S., Waldmann H., Kolb H. 1987. L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice. Clin. Exp. Immunol. 70: 585-592
13. Herold K.C., Bloch T.N., Vezys V., Sun Q. 1995. Diabetes induced with low doses of streptozotocin in mediated by Vß8.2+ T-cells. Diabetes 44: 354-359
14. Paik S.-G., Blue M.L., Fleischer N., Shin S.-I. 1982. Diabetes susceptibility of Balb/cBOM mice treated with streptozotocin. Inhibition by lethal irradiation and restoration by splenic lymphocytes. Diabetes 31: 808-815
15. Nedergaard M., Egeberg J., Kromann H. 1983. Irradiation protects against pancreatic islet degeneration and hyperglycaemia following streptozotocin treatment in mice. Diabetologia 24: 382-386
16. Campbell I.L., Oxbrow L., Koulmanda M., Harrison L.C. 1988. IFN-γ induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse. J. Immunol. 140: 1111-1116
17. Mosmann T.R. 1994. Properties and functions of interleukin-10. Advances in Immunology 56: 1-26
18. Fiorentino D.F., Zlotnik A., Mosmann T.R., Howard M., O'Garra A.O. 1991. IL10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815-3822
19. Gazzinelli R.T., Oswald I.P., James S.L., Sher A. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ activated macrophages. J. Immunol. 148: 1792-1797
20. Ding L., Shevach E.M. 1992. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol. 148: 3133-3139
21. Sher A., Fiorentino D., Caspar P., Pearce E., Mosmann T. 1991. Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J. Immunol. 147: 2713-2716
22. Wogensen L., Huang X., Sarvetnick N. 1993. Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin-10 in the islets of Langerhans. J. Exp. Med. 178: 175-185
23. Wogensen L., Lee M.-S., Sarvetnick N. 1994. Production of interleukin-10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice. J. Exp. Med. 179: 1379-1384
24. Lee M.-S., Wogensen L., Shizuru J., Oldstone M.B.A., Sarvetnick N. 1994. Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J. Clin. Invest. 93: 1332-1338
25. Wicker L.S., Miller B.J., Mullen Y. 1986. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35: 855-860
26. Duijvestijn A., Hamann A. 1989. Mechanisms and regulation of lymphocyte migration. Immunology Today 10: 23-28
27. Kansas G.S. 1992. Structure and function of L-selectin. APMIS 100: 287-293
28. Schwarz R.H. 1992. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy Cell 71: 1065-1068
29. Cockfield SM., Ramassar V., Urmson J., Halloran P.F. 1989. Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-γ. J. Immunol. 142: 1120-1128
30. Sai P., Maugendre D., Loreal O., Maurel C., Pogu S. 1988. Effects of cyclosporin on autoimmune diabetes induced in mice by streptozotocin. Diabetes and Metabolism 14: 455-462
31. Blay R.A., Bigley N.J., Giron D.J. 1985. A murine model of insulin-dependent diabetes mellitus resulting from the cumulative effects of the nondiabetic strain of encephalomyocarditis virus and a single low dose of streptozotocin. Diabetes 34: 1288-1292
32. Ihm S.H., Lee K.U., McArthur R.G., Yoon J.W. 1990. Predisposing effect of anti-beta cell autoimmune process in NOD mice on the induction of diabetes by environmental insults. Diabetologia 33: 709-712
33. Gerling I.C., Friedman H., Greiner D.L., Shultz L.D., Leiter E.H. 1994. Multiple low-dose streptozotocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes 43: 433-440
34. Rossini A.A., Williams R.M., Appel M.C., Like A.A. 1978. Sex differences in the multiple dose streptozotocin model of diabetes. Endocrinology 103: 1518-1520
35. Leiter E.H. 1985. Differential susceptibility of Balb/c sublines to diabetes induction by multi-dose streptozotocin treatment. Current Topics in Microbiology and Immunology 122: 78-85
36. Leiter E.H., Le PH., Prochazka M., Worthen S.M., Huppi K. 1988. Genetic and environmental control of diabetes induction by multi-dose streptozotocin in two BALB/c substrains. Diabetes Research 9: 5-10
37. Schwizer R.W., Leiter E.H., Evans R. 1984. Macrophage-mediated cytotoxicity against cultured pancreatic islet cells. Transplantation 37: 539-544
38. Lee K.-I., Amano K., Yoon J.-W. 1988. Evidence for initial involvement of macrophages in development of insulitis in NOD mice. Diabetes 37: 989-991
39. Zunino S.J., Simons L.F., Sambrook J.F., Gething M.J.H. 1994. Interleukin-1 promotes hyperglycemia and insulitis in mice normally resistant to streptozotocin-induced diabetes. Am. J. Pathol. 145: 661-669
40. Pennline K., Roque-Gaffney E., Monahan M. 1994. Recombinant human IL-10 (rhuIL-10) prevents the onset of diabetes in the nonobese diabetic (NOD) mouse. Clin. Immunol. Immunopathol. 71: 169-175
41. Moritani M., Yoshimoto K., Tashiro F., Hashimoto C., Miyazaki J., Ii S., Kudo E., Iwahana H., Hayashi Y., Sano T., Itakura M. 1994. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. International Immunology 6: 1927-1936