Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation

Molecular Therapy

Volumn 2, Issue 1, 2000, Pages 39-46

  Chen, Shu Hsia ^a   Pham Nguyen, Khiem B ^a   Martinet, Olivier ^a   Huang, Yunzhong ^a   Yang, Wen ^a   Thung, Swan N ^a   Chen, Lieping ^b   Mittler, Robert ^c   Woo, Savio L C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

4 1BB; Colon metastases; Gene therapy; IL 12; Immune modulation

Indexed keywords

ADENOVIRIDAE; ANIMALIA; MURINAE;

CD137 ANTIGEN; CD137 LIGAND; INTERLEUKIN 12; LEUKOCYTE ANTIGEN; NERVE GROWTH FACTOR RECEPTOR; TNFRSF9 PROTEIN, MOUSE; TNFSF9 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ADENOVIRUS; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; COLON TUMOR; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE THERAPY; GENETICS; LIVER; LIVER TUMOR; LUNG TUMOR; METABOLISM; METASTASIS; METHODOLOGY; MOUSE; MULTIMODALITY CANCER THERAPY; NATURAL KILLER CELL; PATHOLOGY; SPLEEN; TIME;

4-1BB LIGAND; ADENOVIRIDAE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD137; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE THERAPY; INTERLEUKIN-12; KILLER CELLS, NATURAL; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034218442     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0086     Document Type: Article

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