Modulation of the immune response through 4-1bb

Advances in Experimental Medicine and Biology

Volumn 465, Issue , 2000, Pages 355-362

  Sica, G ^a   Chen, L ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD137 ANTIGEN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 10; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; VASCULOTROPIN;

AUTOIMMUNE DISEASE; CANCER IMMUNOTHERAPY; CYTOTOXIC T LYMPHOCYTE; FIBROSARCOMA; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEART TRANSPLANTATION; HELPER CELL; HUMAN; MASTOCYTOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN ALLOGRAFT; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNOLOGY;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD137; HUMANS; LIGANDS; NEOPLASMS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; TRANSPLANTATION;

EID: 0034482741     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (31)

1. Molecular and biological characterization of human 4-1BB and its ligand
2. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
3. Immunological ignorance of silent antigens as an explanation of tumor evasion
4. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
5. The host-tumor immune conflict: From immunosuppression to resistance and destruction
6. Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells
7. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP
8. Costimulation of CD28- T lymphocytes by 4-1BB ligand
9. 4-1BB is expressed on CD45RAhiROhi transitional T cell in humans
10. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: A member of an emerging family of cytokines with homology to tumor necrosis factor
11. Can co-stimulated tumor immunity be therapeutically efficacious?
12. Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28
13. Human 4-1BB (CD137) signals are medi-ated by TRAF2 and activate nuclear factor-kappa B
14. Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses
15. Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p561ck1
16. Expression characteristics of two potential T cell mediator genes
17. CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling
18. Costimulation by CD48 and B7-B1 induces immunity against poorly immunogenic tumors
19. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
20. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
21. A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis
22. The role of eosinophils in the pathobiology of Hodgkin's disease
23. Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4
24. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells
25. Inducible T cell antigen 4-1BB. Analysis of expression and function
26. CD28-independent and TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
27. ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival
28. A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family
29. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
30. Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes