메뉴 건너뛰기




Volumn 80, Issue 8-9, 1998, Pages 651-658

Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth

Author keywords

IRFs; Transcription

Indexed keywords

CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 2; TRANSCRIPTION FACTOR;

EID: 0032131490     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(99)80018-2     Document Type: Article
Times cited : (73)

References (50)
  • 1
    • 0009477934 scopus 로고    scopus 로고
    • The role of cytokines in viral infections
    • Mahy B.W.J., Collier L. (Eds.), Arnold Publications, Great Britain
    • [1] Kunzi M., Pitha P.M., The role of cytokines in viral infections, in: Mahy B.W.J., Collier L. (Eds.), Topley & Wilson's Microbiology and Microbial Infections 9nd edn., Virology Vol 1, Arnold Publications, Great Britain, 1998, pp. 93-210.
    • (1998) Topley & Wilson's Microbiology and Microbial Infections 9nd Edn., Virology , vol.1 , pp. 93-210
    • Kunzi, M.1    Pitha, P.M.2
  • 2
    • 0031418944 scopus 로고    scopus 로고
    • The growing family of interferon regulatory factors
    • [2] Nguyen H., Hiscott J., Pitha P.M., The growing family of interferon regulatory factors, Cyt. Growth Fact. Rev. 8 (1998) 293-312.
    • (1998) Cyt. Growth Fact. Rev. , vol.8 , pp. 293-312
    • Nguyen, H.1    Hiscott, J.2    Pitha, P.M.3
  • 3
    • 0024380583 scopus 로고
    • Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    • [3] Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata T., Taniguchi T., Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58 (1989) 729-739.
    • (1989) Cell , vol.58 , pp. 729-739
    • Harada, H.1    Fujita, T.2    Miyamoto, M.3    Kimura, Y.4    Maruyama, M.5    Furia, A.6    Miyata, T.7    Taniguchi, T.8
  • 5
    • 0028075947 scopus 로고
    • Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes
    • [5] Reis L.F., Ruffner H., Stark G., Aguetand M., Weissmann C., Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes, EMBO J. 13 (1994) 4798-4806.
    • (1994) EMBO J. , vol.13 , pp. 4798-4806
    • Reis, L.F.1    Ruffner, H.2    Stark, G.3    Aguetand, M.4    Weissmann, C.5
  • 7
    • 0025243645 scopus 로고
    • Interferon-dependent transcriptional activation: Signal transduction without second messenger involvement?
    • [7] Levy D., Darnell Jr. J.E., Interferon-dependent transcriptional activation: signal transduction without second messenger involvement? New. Biol. 2 (1990) 923-928.
    • (1990) New. Biol. , vol.2 , pp. 923-928
    • Levy, D.1    Darnell J.E., Jr.2
  • 8
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF3: One gene encodes the 91-and 84-kDa ISGF3 proteins that are activated by interferon alpha
    • [8] Schindler C., Fu X.Y., Improta T., Aebersold R.H., Darnell Jr. J.E., Proteins of transcription factor ISGF3: one gene encodes the 91-and 84-kDa ISGF3 proteins that are activated by interferon alpha, Proc. Natl. Acad. Sci. USA 89 (1992) 7836-7839.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.Y.2    Improta, T.3    Aebersold, R.H.4    Darnell J.E., Jr.5
  • 9
    • 0026778338 scopus 로고
    • Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and myb families of DNA-binding proteins
    • [9] Veals S.A., Schindler C., Leonard D., Fu X.Y., Aebersold R., Darnell Jr. J.E., Levy D.E., Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and myb families of DNA-binding proteins, Mol. Cell. Biol. 12 (1994) 3315-3324.
    • (1994) Mol. Cell. Biol. , vol.12 , pp. 3315-3324
    • Veals, S.A.1    Schindler, C.2    Leonard, D.3    Fu, X.Y.4    Aebersold, R.5    Darnell J.E., Jr.6    Levy, D.E.7
  • 11
    • 0026461132 scopus 로고
    • Human interferon consensus sequence binding protein a negative regulator of enhancer elements to interferon-inducible genes
    • [11] Weisz A., Marx P., Sharf R., Appella E., Driggers P.H., Ozato K., Levi B.Z., Human interferon consensus sequence binding protein a negative regulator of enhancer elements to interferon-inducible genes, J. Biol. Chem. 267 (1992) 25589-25596.
    • (1992) J. Biol. Chem. , vol.267 , pp. 25589-25596
    • Weisz, A.1    Marx, P.2    Sharf, R.3    Appella, E.4    Driggers, P.H.5    Ozato, K.6    Levi, B.Z.7
  • 13
    • 0029763203 scopus 로고    scopus 로고
    • Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1
    • [13] Brass A.L., Kehrli E., Eisenbeis C.F., Storb U., Singh H., Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1, Genes Dev. 10 (1996) 2335-2347.
    • (1996) Genes Dev. , vol.10 , pp. 2335-2347
    • Brass, A.L.1    Kehrli, E.2    Eisenbeis, C.F.3    Storb, U.4    Singh, H.5
  • 15
    • 0028795052 scopus 로고
    • Induction of interferon alpha gene expression
    • [15] Pitha P.M., Au W.C., Induction of interferon alpha gene expression, Semin. Virol. 6 (1995) 151-159.
    • (1995) Semin. Virol. , vol.6 , pp. 151-159
    • Pitha, P.M.1    Au, W.C.2
  • 16
    • 0028796833 scopus 로고
    • Molecular mechanisms of interferon beta gene induction
    • [16] Hiscott J., Nguyen H., Lin R., Molecular mechanisms of interferon beta gene induction, Semin. Virol. 6 (1995) 161-173.
    • (1995) Semin. Virol. , vol.6 , pp. 161-173
    • Hiscott, J.1    Nguyen, H.2    Lin, R.3
  • 17
    • 0031310825 scopus 로고    scopus 로고
    • The mechanism of transcriptional synergy of an in vitro assembled interferon-β enhanceosome
    • [17] Kim T.K., Maniatis T., The mechanism of transcriptional synergy of an in vitro assembled interferon-β enhanceosome, Mol. Cell. 1 (1997) 119-129.
    • (1997) Mol. Cell. , vol.1 , pp. 119-129
    • Kim, T.K.1    Maniatis, T.2
  • 18
    • 0022423154 scopus 로고
    • Characterization of a mouse interferon gene locus II. Differential expression of α-interferon genes
    • [18] Kelley K.A., Pitha P.M., Characterization of a mouse interferon gene locus II. Differential expression of α-interferon genes, Nucleic Acids Res. 13 (1985) 825-839.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 825-839
    • Kelley, K.A.1    Pitha, P.M.2
  • 19
    • 0021760405 scopus 로고
    • Differential expression of human interferon genes
    • [19] Hiscott J., Cantell K., Weissmann C., Differential expression of human interferon genes, Nucleic Acids Res. 12 (1984) 3727-3746.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 3727-3746
    • Hiscott, J.1    Cantell, K.2    Weissmann, C.3
  • 20
    • 0026089936 scopus 로고
    • Multimerization of AAGTGA and GAAAGT generates sequences that mediate virus inducibility by mimicking an interferon promoter element
    • [20] Naf D., Hardin S.E., Weissmann C., Multimerization of AAGTGA and GAAAGT generates sequences that mediate virus inducibility by mimicking an interferon promoter element, Proc. Natl. Acad. Sci. USA 88 (1991) 1369-1373.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1369-1373
    • Naf, D.1    Hardin, S.E.2    Weissmann, C.3
  • 21
    • 0026639492 scopus 로고
    • Distinct activation of murine interferon-α promoter region by IRF-1/ISFG-2 and virus infection
    • [21] Au W.C., Raj N.B.K., Pitha P.M., Distinct activation of murine interferon-α promoter region by IRF-1/ISFG-2 and virus infection, Nucleic Acids Res 20 (1992) 2877-2884.
    • (1992) Nucleic Acids Res , vol.20 , pp. 2877-2884
    • Au, W.C.1    Raj, N.B.K.2    Pitha, P.M.3
  • 22
    • 0024546241 scopus 로고
    • Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
    • [22] Fujita T., Kimura Y., Miyamoto M., Barsoumian E.L., Taniguchi T., Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1, Nature 337 (1989) 270-272.
    • (1989) Nature , vol.337 , pp. 270-272
    • Fujita, T.1    Kimura, Y.2    Miyamoto, M.3    Barsoumian, E.L.4    Taniguchi, T.5
  • 24
    • 0029618697 scopus 로고
    • Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes
    • [24] Au W.C., Moore P.A., Lowther W., Juang Y.T., Pitha P.M., Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes, Proc. Natl. Acad. Sci. USA 92 (1995) 11657-11661.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11657-11661
    • Au, W.C.1    Moore, P.A.2    Lowther, W.3    Juang, Y.T.4    Pitha, P.M.5
  • 25
    • 0032579369 scopus 로고    scopus 로고
    • Regulation of type I interferon gene expression by interferon regulatory factor-3
    • [25] Schafer S.L., Lin R., Moore P.A., Hiscott J., Pitha P.M., Regulation of type I interferon gene expression by interferon regulatory factor-3, J. Biol. Chem. 273 (1998) 2714-2720.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2714-2720
    • Schafer, S.L.1    Lin, R.2    Moore, P.A.3    Hiscott, J.4    Pitha, P.M.5
  • 26
    • 85030362557 scopus 로고    scopus 로고
    • The HPV-16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
    • [26] Ronco L.V., Stevenson L., Vidal M., Howley P.M., The HPV-16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity, J. Interferon Cytokine Res. 17 (suppl. 2), (1997) S37.
    • (1997) J. Interferon Cytokine Res. , vol.17 , Issue.SUPPL. 2
    • Ronco, L.V.1    Stevenson, L.2    Vidal, M.3    Howley, P.M.4
  • 27
    • 0026741769 scopus 로고
    • Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection
    • [27] Pine R., Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection, J. Virol. 66 (1992) 4470-4478.
    • (1992) J. Virol. , vol.66 , pp. 4470-4478
    • Pine, R.1
  • 28
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • [28] Darnell Jr. J.E., Kerr I.M., Stark G.R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science 264 (1994) 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell J.E., Jr.1    Kerr, I.M.2    Stark, G.R.3
  • 29
    • 0031893220 scopus 로고    scopus 로고
    • Virus dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential and proteasome mediated degradation
    • [29] Lin R., Heylbroech C., Pitha P., Hiscott J., Virus dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential and proteasome mediated degradation, Mol. Cell. Biol. 18 (1998) 2986-2996.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2986-2996
    • Lin, R.1    Heylbroech, C.2    Pitha, P.3    Hiscott, J.4
  • 30
    • 0032582712 scopus 로고    scopus 로고
    • Characterisation of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes
    • in press
    • [30] Au W.-Ch., Moore P.A., La Fleur D.W., Tombal B., Pitha P.M., Characterisation of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes, J. Biol. Chem. (1998), in press.
    • (1998) J. Biol. Chem.
    • Au, W.-Ch.1    Moore, P.A.2    La Fleur, D.W.3    Tombal, B.4    Pitha, P.M.5
  • 31
    • 85030366490 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 is a subunit of the dsRNA activated factor, DRAF1
    • [31] Weaver B., Kumar P., Reich N.C., Interferon regulatory factor 3 is a subunit of the dsRNA activated factor, DRAF1, J. Interferon Cytokine Res. 17 (suppl. 2), (1997) S36.
    • (1997) J. Interferon Cytokine Res. , vol.17 , Issue.SUPPL. 2
    • Weaver, B.1    Kumar, P.2    Reich, N.C.3
  • 32
    • 0025874550 scopus 로고
    • Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: Block in transcriptional complex formation
    • [32] Kalvakolanu D,V.R., Bandyopadhyay S.K., Harter M.L., Sen G.S., Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation, Proc. Natl. Acad. Sci. USA 88 (1991) 7459-7463.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7459-7463
    • Kalvakolanu, D.V.R.1    Bandyopadhyay, S.K.2    Harter, M.L.3    Sen, G.S.4
  • 33
    • 0031060533 scopus 로고    scopus 로고
    • The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element
    • [33] Nonkwelco C., Ruf I.K., Sample J., The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element, J. Virol. 71 (1997) 354-361.
    • (1997) J. Virol. , vol.71 , pp. 354-361
    • Nonkwelco, C.1    Ruf, I.K.2    Sample, J.3
  • 34
    • 0030820054 scopus 로고    scopus 로고
    • IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency
    • [34] Zhang L., Pagano J.S., IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency, Mol. Biol Cell. 17 (1998) 5748-5757.
    • (1998) Mol. Biol Cell. , vol.17 , pp. 5748-5757
    • Zhang, L.1    Pagano, J.S.2
  • 36
    • 0029974841 scopus 로고    scopus 로고
    • Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus
    • [36] Nador R.G., Cesarman E., Chadburn A., Dawson D.B., Ansari M.Q., Said J., Knowles D.M., Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus, Blood 88 (1996) 645-656.
    • (1996) Blood , vol.88 , pp. 645-656
    • Nador, R.G.1    Cesarman, E.2    Chadburn, A.3    Dawson, D.B.4    Ansari, M.Q.5    Said, J.6    Knowles, D.M.7
  • 38
    • 0031017578 scopus 로고    scopus 로고
    • A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
    • [38] Cheng E.H.Y., Nicholas J., Bellows D., Hayward G.S., Guo H.G., Reitz M.S., Hardwick J.M., A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak, Proc. Natl. Acad. Sci. USA 94 (1997) 690-694.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 690-694
    • Cheng, E.H.Y.1    Nicholas, J.2    Bellows, D.3    Hayward, G.S.4    Guo, H.G.5    Reitz, M.S.6    Hardwick, J.M.7
  • 39
    • 0028588064 scopus 로고
    • Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    • [39] Chang Y., Cesarman E., Pessin M.S., Lee F., Culpepper J., Knowles D.M., Moore P.S., Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science 266 (1994) 1865-1869.
    • (1994) Science , vol.266 , pp. 1865-1869
    • Chang, Y.1    Cesarman, E.2    Pessin, M.S.3    Lee, F.4    Culpepper, J.5    Knowles, D.M.6    Moore, P.S.7
  • 40
    • 0029837991 scopus 로고    scopus 로고
    • Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
    • [40] Moore P.S., Boshoff C., Weiss R.A., Chang Y., Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV, Science 274 (1996) 1739-1744.
    • (1996) Science , vol.274 , pp. 1739-1744
    • Moore, P.S.1    Boshoff, C.2    Weiss, R.A.3    Chang, Y.4
  • 41
    • 0031034118 scopus 로고    scopus 로고
    • PU.1 can participate in an active enhancer complex without its transcriptional activation domain
    • [41] Pongubala J.M.R., Atchison M.L., PU.1 can participate in an active enhancer complex without its transcriptional activation domain, Proc. Natl. Acad. Sci. USA 94 (1997) 127-132.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 127-132
    • Pongubala, J.M.R.1    Atchison, M.L.2
  • 42
    • 0030665032 scopus 로고    scopus 로고
    • KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway
    • [42] Gao S.J., Boshoff C., Jayachandra S., Weiss R.A., Chang Y., Moore P.S., KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway, Oncogene 85 (1997) 1979-1985.
    • (1997) Oncogene , vol.85 , pp. 1979-1985
    • Gao, S.J.1    Boshoff, C.2    Jayachandra, S.3    Weiss, R.A.4    Chang, Y.5    Moore, P.S.6
  • 43
    • 0031964683 scopus 로고    scopus 로고
    • Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription
    • [43] Zimring J.C., Goodbourn S., Offermann M.K., Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription, J. Virol. 72 (1998) 701-707.
    • (1998) J. Virol. , vol.72 , pp. 701-707
    • Zimring, J.C.1    Goodbourn, S.2    Offermann, M.K.3
  • 44
    • 0031604766 scopus 로고    scopus 로고
    • Recruitment of CBP/p300 by the IFN beta enhanceosomeis required for synergistic activation of transcription
    • [44] Merika M., Williams A.J., Chen G., Collins T., Thanos D., Recruitment of CBP/p300 by the IFN beta enhanceosomeis required for synergistic activation of transcription, Mol. Cell. 1 (1998) 277-287.
    • (1998) Mol. Cell. , vol.1 , pp. 277-287
    • Merika, M.1    Williams, A.J.2    Chen, G.3    Collins, T.4    Thanos, D.5
  • 45
    • 0032544059 scopus 로고    scopus 로고
    • Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor-3
    • [45] Juang Y.T., Lowther W., Kellum M., Au W.C., Lin R., Hiscott J., Pitha P.M., Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor-3, Proc. Natl. Acad. Sci. USA 95 (1998) 9837-9842.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9837-9842
    • Juang, Y.T.1    Lowther, W.2    Kellum, M.3    Au, W.C.4    Lin, R.5    Hiscott, J.6    Pitha, P.M.7
  • 46
    • 0031932892 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
    • [46] Weaver B.K., Kumar K.P., Reich N.C., Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1, Mol. Cell. Biol. 18 (1998) 1359-1368.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1359-1368
    • Weaver, B.K.1    Kumar, K.P.2    Reich, N.C.3
  • 47
    • 0032481352 scopus 로고    scopus 로고
    • Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
    • [47] Yonegama M., Suhara W., Fukuhara Y., Fukuda M., Nishida E., Fujita T., Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300, EMBO J. 17 (1998) 1087-1095.
    • (1998) EMBO J. , vol.17 , pp. 1087-1095
    • Yonegama, M.1    Suhara, W.2    Fukuhara, Y.3    Fukuda, M.4    Nishida, E.5    Fujita, T.6
  • 48
    • 0032549658 scopus 로고    scopus 로고
    • Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
    • [48] Sato M., Tanaka N., Hata N., Oda E., Taniguchi T., Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene, FEBS Lett. 425 (1998) 112-116.
    • (1998) FEBS Lett. , vol.425 , pp. 112-116
    • Sato, M.1    Tanaka, N.2    Hata, N.3    Oda, E.4    Taniguchi, T.5
  • 49
    • 0032015647 scopus 로고    scopus 로고
    • Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
    • [49] Wathelet M.G., Lin C.H., Parekh B.S., Ronco L.V., Howley P.M., Maniatis T., Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo, Mol. Cell. 1 (1998) 507-518.
    • (1998) Mol. Cell. , vol.1 , pp. 507-518
    • Wathelet, M.G.1    Lin, C.H.2    Parekh, B.S.3    Ronco, L.V.4    Howley, P.M.5    Maniatis, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.