Hemoglobin-degrading, aspartic proteases of blood-feeding parasites. Substrate specificity revealed by homology models

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 38844-38851

  Brinkworth, Ross I ^a   Prociv, Paul ^a   Loukas, Alex ^b   Brindley, Paul J ^c,d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c TULANE UNIVERSITY   (United States)

^d TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; DISEASE CONTROL; ENZYMES; HEMOGLOBIN;

PARASITES;

BLOOD;

ANTIPARASITIC AGENT; ASPARTIC PROTEINASE; CATHEPSIN D; ENZYME INHIBITOR; HEMOGLOBIN; OCTAPEPTIDE; PEPSTATIN; PROTEIN INHIBITOR; RENIN;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HOOKWORM; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCHISTOSOMA; SCHISTOSOMA JAPONICUM; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ANCYLOSTOMATOIDEA; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PROTOZOA; SCHISTOSOMA; SCHISTOSOMA JAPONICUM; TREMATODA;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATALYSIS; CATHEPSIN D; CRYSTALLOGRAPHY, X-RAY; HEMOGLOBINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0035914328     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101934200     Document Type: Article

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