Differential regulation of p21(waf-1/cip-1) and Mdm2 by etoposide: Etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

Oncogene

Volumn 18, Issue 4, 1999, Pages 1081-1091

  Arriola, Emma L ^a   Rodriguez Lopez, Ana ^a   Chresta, Christine M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Apoptosis; Etoposide; Mdm2; p53; Testicular neoplasms

Indexed keywords

ANTINEOPLASTIC AGENT; ETOPOSIDE; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; RNA; BLEOMYCIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DNA; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN;

APOPTOSIS; ARTICLE; AUTOREGULATION; BLADDER CARCINOMA; CANCER CELL CULTURE; CLONOGENESIS; CONTROLLED STUDY; CULTURE MEDIUM; DNA DAMAGE; DOSE RESPONSE; DOWN REGULATION; FEEDBACK SYSTEM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NON SEMINOMATOUS GERMINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; TRANSACTIVATION; TRANSITIONAL CELL CARCINOMA; BLADDER TUMOR; CELL CULTURE; DNA REPAIR; DRUG EFFECT; GENETICS; MALE; METABOLISM; TESTIS; TESTIS TUMOR;

VIOLA (ANGIOSPERM);

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLEOMYCIN; CARCINOMA, TRANSITIONAL CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; ETOPOSIDE; FEEDBACK; HUMANS; MALE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TESTICULAR NEOPLASMS; TESTIS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS;

EID: 0033611413     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202391     Document Type: Article

References (56)

1. Barak Y, Gottlieb E, Juven GT and Oren M. (1994). Genes Dev., 8, 1739-1749.
2. Barbareschi M, Girlando S, Fellin G, Graffer U, Luciani L and DallaPalma P. (1995). Urol. Res., 22, 349-352.
3. Bertrand R, Sarang M, Jenkin J, Kerrigan D and Pommier Y. (1991). Cancer Res., 51, 6280-6285.
4. Blaydes JP, Gire V, Rowson JM and Wynford-Thomas D. (1997). Oncogene, 14, 1859-1868.
5. Bottger A, Bottger V, Sparks A, Liu WL, Howard SF and Lane DP. (1997). Curr. Biol., 7, 860-869.
6. Canman CE, Wolff AC, Chen CY, Fornace AJ and Kastan MB. (1994). Cancer Res., 54, 5054-5058.
7. Chen CY, Oliner JD, Zhan Q, Fornace AJ, Vogelstein B and Kastan MB. (1994). Proc. Natl. Acad. Sci. USA, 91, 2684-2688.
8. Chen JD, Lin JY and Levine AJ. (1995). Mol. Med., 1, 141-142.
9. Chen JD, Wu X, Lin JY and Levine AJ. (1996). Mol. Cell. Biol., 16, 2445-2452.
10. Chen L, Agrawal S, Zhou W, Zhang R and Chen J. (1998). Proc. Natl. Acad. Sci. USA, 95, 195-200.
11. Chresta CM, Masters JRW and Hickman JA. (1996). Cancer Res., 56, 1834-1841.
12. Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF and Levine AJ. (1994). Cancer Res., 54, 794-799.
13. deJong S, Dam WA, deVries EGE and Muldner NH. (1997). Proc. AACR, 38, 638.
14. Dubs-Poterszman MC, Tocque B and Wasylyk B. (1995). Oncogene, 11, 2445-2449.
15. Erhardt P, Tomaselli KJ and Cooper GM. (1997). J. Biol. Chem., 272, 15049-15052.
16. Fakharzadeh SS, Trusko SP and George DL. (1991). EMBO J., 10, 1565-1569.
17. Finlay CA. (1993). Mol. Cell. Biol., 13, 301-306.
18. Fleischhacker M, Strohmeyer T, Imai Y, Slamon DJ and Koeffler HP. (1994). Mod. Pathol., 7, 435-439.
19. Guillou L, Estreicher A, Chaubert P, Hurlimann J, Kurt AM, Metthez G, Iggo R, Gray AC, Jichlinski P, Leisinger HJ and Benhattar J. (1996). Am. J. Path., 149, 1221-1228.
20. Haines DS. (1997). Leukemia and Lymphoma, 26, 227-238.
21. Haupt Y, Barak Y and Oren M. (1996). EMBO J., 15, 1596-1606.
22. Haupt Y, Maya R, Kazaz A and Oren M. (1997). Nature, 387, 296-299.
23. Jones SN, Roe AE, Donehower LA and Bradley A. (1995). Nature, 378, 206-208.
24. Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF and Meek DW. (1997). Oncogene, 15, 1727-1736.
25. Knippschild U, Milne DM, Campbell LE and Meek DW. (1996). Oncogene, 13, 1387-1393.
26. Kohn KW, Erickson LC, Ewig R and Friedman CA. (1976). Biochemistry, 15, 4629-4637.
27. Kondo S, Barnett GH, Hara H, Morimura T and Takeuchi J. (1995). Oncogene, 10, 2001-2006.
28. Kubbutat MHG, Jones SN and Vousden KH. (1997). Nature, 387, 299-303.
29. Landers JE, Cassei SL and George DL. (1997). Cancer Res., 57, 3562-3568.
30. Levine AJ. (1990). Virology, 177, 419-426.
31. Lianes P, Orlow I, Zhang ZF, Olvia MR, Sarkins AS, Reuter VE and Cordon-Cardo C. (1994). J. Natl. Cancer Inst., 86, 1325-1330.
32. Ljungman M and Zhang F. (1996). Oncogene, 13, 823-831.
33. Lu X, Burbridge SA, Griffin S and Smith HM. (1996). Oncogene, 13, 413-418.
34. Lu X and Lane DP. (1993). Cell, 75, 765-778.
35. Lutzker SG and Levine AJ. (1996). Nature Med., 2, 804-810.
36. Maki CG and Howley PM. (1997). Mol. Cell. Biol., 17, 355-363.
37. Martin K, Trouche D, Hagemeier C, Sorensen TS, La TN and Kouzarides T. (1995). Nature, 375, 691-694.
38. Momand J, Zambetti GP, Olson DC, George D and Levine AJ. (1992). Cell, 69, 1237-1245.
39. Montes-de-Oca-Luna R, Wagner DS and Lozano G. (1995). Nature, 378, 203-206.
40. Oliner JD, Kinzler KW, Meltzer PS, George DL and Vogelstein B. (1992). Nature, 358, 80-83.
41. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW and Vogelstein B. (1993). Nature, 362, 857-860.
42. Perry ME, Piette J, Zawadzki JA, Harvey D and Levine AJ. (1993). Proc. Natl. Acad. Sci. USA, 90, 11623-11627.
43. Reich NC, Oren M and Levine AJ. (1983). Mol. Cell. Biol., 3, 2143-2150.
44. Reinke V and Lozano G. (1997). Radiation Res., 148, 115-122.
45. Rieger KM, Little AF, Swart JM, Kastrinakis WV, Fitzgerald JM, Hess DT, Libertino JA and Summerhayes IC. (1995). Br. J. Cancer, 72, 683-690.
46. Riou G, Barrios M, Prost S, Terrier MJ, Theodore C and Levine AJ. (1995). Mol. Carcinog., 12, 124-131.
47. Riou JF, Gabillot M and Riou G. (1993). FEBS Lett., 334, 369-372.
48. Sambrook J, Fritsch EF and Maniatis T. (1989). Molecular cloning: A laboratory manual (CSH, 1989).
49. Shaulian E, Resnitzky D, Shifman O, Blandino G, Amsterdam A, Yayon A and Oren M. (1997). Oncogene, 15, 2717-2725.
50. Shieh SY, Ikeda M, Taya Y and Prives C. (1997). Cell, 91, 325-334.
51. Sigalas I, Calvert AH, Anderson JJ, Neal DE and Lunec J. (1996). Nature Med., 2, 912-917.
52. Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E and Kastan MB. (1997). Genes Dev., 11, 3471-3481.
53. Weinberg R. (1993). Neuron, 11, 191-196.
54. Wu L and Levine AJ. (1997). Molec. Med., 3, 441-451.
55. Xiao G, White D and Bargonetti J. (1998). Oncogene, 16, 1171-1181.
56. Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR and Livingston DM. (1995). Nature, 375, 694-697.