Analysis of the immune response elicited by a Multiple Antigen Peptide (MAP) composed of two distinct protective antigens derived from the parasite Schistosoma mansoni

Parasite Immunology

Volumn 19, Issue 1, 1997, Pages 1-12

  Ferru, I ^a   Georges, B ^a   Bossus, M ^a   Estaquier, J ^a   Delacre, M ^a   Harn, D A ^b   Tartar, A ^a   Capron, A ^a   Grassmasse, H ^a   Auriault, C ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

B cell response; cytokines; immunogenicity; Multiple Antigen Peptide; T cell response

Indexed keywords

GAMMA INTERFERON; MULTIPLE ANTIGEN PEPTIDE; PARASITE ANTIGEN; SCHISTOSOMA VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; T LYMPHOCYTE;

EID: 8044234376     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1997.d01-138.x     Document Type: Article

References (42)

1. Balloul J.M., Pierce R.J., Grzych J.M. & Capron A. (1985) In vitro synthesis of a 28 kilodalton antigen present on the surface of the schistosomulum of S. mansoni. Molecular and Biochemical Parasitology 17, 105-114
2. Balloul J.M., Sondermeyer P., Dreyer D., et al. (1987a) Molecular cloning of a protective antigen of schistosomes. Nature 326, 149-153
3. Balloul J.M., Grzych J.M., Pierce R.J. & Capron A. (1987b) A purified 28000 Dalton protein from Schistosoma mansoni adult worms protects rat and mice against experimental schistosomiasis. Journal of Immunology. 138, 3448-3453
4. Bittle J.L., Houghten R.A., Alexander H. et al. (1982) Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature 298, 30-33
5. Boulanger D., Reid C.D.F., Sturrock R.F. et al. (1991) Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoni. Parasite Immunology 13, 473-490
6. Capron A., Balloul J.M., Grezel D. et al. (1990) Progress towards vaccine against schistosomiasis. Molecular Aspects of Immune Response and Infectious Diseases 183-191.
7. Czaja M.J., Weiner F.R., Takahashi S. et al. (1989) Gamma interferon treatment inhibits collagen deposition in murine schistosomiasis. Hepathology 10, 795-800
8. Darcy F., Maes P., Gras-Masse H. et al. (1992) Protection of mice and nude rats against toxoplasmosis by a multiple antigenic peptide construction derived from Toxoplasma gondii P30 antigen. Journal of Immunology 149, 3636-3641
9. Defoort J.P., Nardelli B., Huang W., Ho D.D. & Tam J.P. (1992) Macromolecular assemblage in the design of a synthetic AIDS vaccine. Proceedings of the National Academy Sciences, USA. 89, 3879-3883
10. Delgado V. & McLaren D.J. (1990) Evidence for enhancement of IgG1 subclass expression in mice polyvaccinated with radiation-atenuated cercariae of Schistosoma mansoni and the role of this isotype in serum-transferred immunity. Parasite Immunology 12, 15-32
11. Del Giudice G., Tougne C., Louis J. et al. (1990) A multiple antigen peptide from the repetitive sequence of the Plasmodium malariae circumsporozoïte protein induces a specific antibody response in mice of various H-2 haplotypes. European Journal of Immunology 20, 1619-1622
12. Emini E.A., Larson V., Eichberg J. et al. (1989) Protective effect of a synthetic peptide comprising the complete PreS2 region of the Hepathitis B virus surface protein. Journal of Medical Virology 28, 7-12
13. Fieser T.M., Tainer J.A., Geysen H.M. et al. (1987) Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein α-helix. Proceedings of the National Academy of Sciences, USA. 84, 8568-8572
14. Harn D.A., Gu W., Oligino L.D. et al. (1992) A protective monoclonal antibody specifically recognizes and alters the catalytic activity of schistosome triose-phosphate isomerase. Journal of Immunology 148, 562-567
15. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proceedings of the National Academy of Sciences, USA. 88, 7011-7015
16. Henrickson K.J., Kingsbury D.W., Wyke V. et al. (1991) Neutralizing epitopes of human para-influenza virus type 3 are conformational and cannot be imitated by synthetic peptides. Vaccine. 9, 243-249
17. James S.L. & Nacy C. (1993) Effector functions of activated macrophages against parasites. Current Opinion on Immunology 5, 518-525
18. Jardim A., Alexander J., Teh H.S. et al. (1990) Immunoprotective Leishmania major synthetic T-cell epitopes. Journal of Experimental Medicine 172, 645-648
19. Mangold B.L. & Dean D.A. (1986) Passive transfer with serum and IgG antibodies of irradiated cercaria-induced resistance against Schistosoma mansoni in mice. Journal of Immunology 136, 2644-2648
20. Marguerite M., Bossus M., Mazingue C. et al. (1992) Analysis of antigenicity and immunogenicity of five different chemically defined constricts of a peptide. Molecular Immunology 29, 793-800
21. McKnight A., Barclay N. & Manson D. (1991) Molecular cloning of rat IL-4 cDNA and analysis of the cytokine repertoire subsets of CD4+ T cells. European Journal of Immunology 21, 1187-1191
22. Morris L., Troutt A.B., McLeod K.S. et al. (1993) IL-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis. Infection and Immunity 61, 3459-3465
23. Muller G., Shapira M. & Arnon R. (1982) Anti-influenza response achieved by immunization with a synthetic conjugate. Proceedings of the National Academy of Sciences, USA 79, 569-573
24. Niman H., Houghten R., Walker L. et al. (1983) Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proceedings of the National Academy of Sciences, USA 80, 4949-4953
25. Oswald I.P., Caspar P., Jankovic D. et al. (1994) IL-12 inhibits TH2 cytokine responses induced by eggs of Schistosoma mansoni. Journal of Immunology 153, 1707-1713
26. Pancré V., Wolowczuk I., Guerret S. et al. (1994) Protective effect of rSm28GST specific T-cells in schistosomiasis: role of gamma interferon. Infection and Immunity 62, 3723-3730
27. Patarroyo M.E., Romero P., Torres M.L. et al. (1987) Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature 328, 629-632
28. Perlmutter R.M., Hansburg D., Briles D.E. et al. (1978) Subclass restriction of murine anticarbohydrate antibodies. Journal of Immunology 121, 566-572
29. Perkin D.L., Berriz G., Kamradt T. (1991) Immunodominance: intramolecular competition between T-cell epitopes. Journal of Immunology 146, 2137-2144
30. Posnett D.N., McGrath H. & Tam J.P. (1988) A novel method for producing anti-peptide antibodies. Journal of Biological Chemistry 263, 1719-1725
31. Reynolds S.R., Dahl C.E. & Harn D. (1994) T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase. Journal of Immunology 152, 193-200
32. Sher A., Coffman R.L., Hieny S. & Cheever A.W. (1990) Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. Journal of Immunology 145, 3911-3916
33. Shoemaker C., Gross A., Gebremichael A. & Harn D. (1992) cDNA cloning and functional expression of the Schistosoma mansoni protective antigen triose-phosphate isomerase. Proceedings of the National Academy of Sciences, USA 89, 1842-1846
34. Smythies L.E., Coulson P.S. & Wilson R.A. (1992) Monoclonal antibody to IFN-γ modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae. Journal of Immunology 146, 3654-3658
35. Tam J.P. (1988) Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigen peptide. Proceedings of the National Academy of Sciences, USA 85, 5409-5413
36. Tam J.P. & Lu Y.A. (1989) Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T and B cell epitopes. Proceedings of the National Academy of Sciences, USA 86, 9084-9088
37. Tam J.P., Clavijo P., Lu Y. et al. (1990) Incorporation of T and B epitopes of the circumsporozoïte protein in a chemically defined synthetic vacine against malaria. Journal of Experimental Medicine 171, 299-306
38. Taylor J.B., Vidal A., Torpier G. et al. (1988) The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni. EMBO. 7, 465-469
39. Troalen F., Razafindratsita A., Puisieux A. et al. (1990) Structural probing of human lutropin using antibodies raised against synthetic peptides constructed by classical and multiple antigen peptide system approaches. Molecular Immunology 27, 363-368
40. Urban J.F., Katona I.M., Paul W.E. & Finkelman F.D. (1991) IL-4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proceedings of the National Academy of Sciences, USA. 88, 5513-3317
41. Wolowczuk I., Auriault C., Bossus M. (1991) Antigenicity and immunogenicity of a multiple peptidic construction of the Schistosma mansoni Sm28GST antigen in rat, mouse and monkey. I-Partial protection of Fisher rat after active immunization. Journal of Immunology 146, 1987-1995
42. Wynn T.A., Eltoum I., Cheever A.W. (1993) Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. Journal of Immunology 151, 1430-1440