Adenoviral Bak overexpression mediates caspase-dependent tumor killing

Cancer Research

Volumn 60, Issue 4, 2000, Pages 788-792

  Pataer, Abujiang ^a   Fang, Bingliang ^a   Yu, Robert ^a   Kagawa, Shunsuke ^a   Hunt, Kelly K ^a   McDonnell, Timothy J ^a   Roth, Jack A ^a   Swisher, Stephen G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; PROTEIN BAK; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL KILLING; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; MOUSE; PRIORITY JOURNAL; TUMOR REGRESSION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; CASPASES; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0034652461     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124: 1-6, 1994.
2. Fang, B., Ji, L., Bouvet, M., and Roth, J. A. Evaluation of GAL4/TATA in vivo: induction of transgene expression by adenovirally mediated gene codelivery. J. Biol. Chem., 273: 4972-4975, 1998.
3. Swisher, S. G., Roth, J. A., Nemunaitis, J., Lawrence, D. D., Kemp, B. L., Carrasco, C. H., Connors, D. G., El-Naggar, A. K., Fossella, F., Glisson, B. S., Hong, W. K., Khuri, F. R., Kurie, J. M., Lee, J. J., Lee, J. S., Mack, M., Merritt, J. A., Nguyen, D. M., Nesbitt, J. C., Perez-Soler, R., Pisters, K. M. W., Putnam, J. B., Jr., Richli, W. R., Savin, M., Schrump, D. S., Shin, D. M., Shulkin, A., Walsh, G. L., Wait, J., Weill, D., and Waugh, M. K. A. Adenoviral-mediated p53 gene transfer in advanced non-small cell lung cancer. J. Natl. Cancer Inst., 91: 763-771, 1999.
4. Clayman, G. L., El-Naggar, A. K., Lippman, S. M., Henderson, Y. C., Frederick, M., Merritt, J. A., Zumstein, L. A., Timmons, T. M., Liu, T-J., Ginsberg, L., Roth, J. A., Hong, W. K., Bruso, P., and Goepfert, H. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J. Clin. Oncol., 16: 2221-2232, 1998.
5. Coll, J. L., Negoescu, A., Louis, N., Sachs, L., Tenaud, C., Girardot, V., Demeinex, B., Brambilla, E., Brambilla, C., and Favrot, M. Antitumor activity of bax and p53 naked gene transfer in lung cancer: in vitro and in vivo analysis. Hum. Gene Ther., 20: 2063-2074, 1998.
6. Orth, K., and Dixit, V. M. Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis. J. Biol. Chem., 272: 8841-8844, 1997.
7. Kiefer, M. C., Brauer, M. J., Powers, V. C., Wu, J. J., Umansky, S. R., Tomei, L. D., and Barr, P. J. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (Lond.), 374: 736-739, 1995.
8. Korsmeyer, S. J., Shutter, J. R., Veis, D. J., Merry, D. E., and Oltvai, Z. N. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer Biol., 4: 327-332, 1993.
9. L and Bcl-2. Oncogene, 15: 1871-1875, 1997.
10. L function and induce apoptosis through cytochrome c-independent activation of caspases. J. Biol. Chem., 274: 13298-13304, 1999.
11. Kurokawa, H., Nishio, K., Fukumoto, H., Tomonari, A., Suzuki, T., and Saijo, N. Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7 breast cancer cells. Oncol. Rep., 6: 33-37, 1999.
12. Xiang, L., Cho, D. T., and Korsmeyer, S. J. BAX-induced cell death may not require interleukin IB-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA, 93: 14559-14563, 1996.
13. Pearson, A. S., Spitz, F. R., Swisher, S. G., Kataoka, M., Sarkiss, M. G., Meyn, R. E., McDonnell, T. J., Cristiano, R. J., and Roth, J. A. Up-regulation of the proapoptotic mediators bax and bak following adenovirus-mediated p53 gene transfer in lung cancer cells. Clin. Cancer Res., in press, 2000.