Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia

Molecular Carcinogenesis

Volumn 21, Issue 1, 1998, Pages 37-49

  Oreffo, Victor I C ^a   Robinson, Susan ^a   You, Ming ^b   Wu, Mau Ching ^c   Malkinson, Alvin M ^d  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Adenocarcinomas; Adenomas; Message stability; Transgenic mice; Tumor suppressor genes

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLARA CELL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; MALE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMALS; DOWN-REGULATION; EPITHELIAL CELLS; GENES, APC; GENES, MCC; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RNA, MESSENGER; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE; MUS MUSCULUS; RODENTIA;

EID: 0031932199     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199801)21:1<37::AID-MC6>3.0.CO;2-M     Document Type: Article

References (59)

1. Minna JD. The molecular biology of lung cancer pathogenesis. Chest 103:449S-456S, 1993.
2. Miura I, Siegfried JM, Resau J, Keller SM, Zhou J-Y, Testa JR. Chromosome alterations in 21 non-small cell lung carcinomas. Genes Chromosome Cancer 2:328-338, 1990.
3. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 55:6200-6209, 1995.
4. Ashton-Rickardt PG, Wyllie AH, Bird CC, et al. MCC, a candidate familial polyposis gene on 5q21, shows frequent allele loss in colorectal and lung cancer. Oncogene 6:1881-1886, 1991.
5. D'Amico D, Carbone DP, Johnson BE, Meltzer SJ, Minna JD. Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer. Cancer Res 52:1996-1999, 1992.
6. Weiland I, Bôhm M. Frequent allelic deletion at a novel locus on chromosome 5 in human lung cancer. Cancer Res 54:1772-1774, 1994.
7. Hosoe S, Ueno K, Shigedo Y, et al. A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung. Cancer Res 54:1787-1790, 1994.
8. Fong KM, Zimmerman PV, Smith PJ. Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer. Cancer Res 55:220-223, 1995.
9. Cooper CA, Bubb VJ, Smithson N, et al. Loss of heterozygosity at 5q21 in non-small cell lung cancer: A frequent event but with-out evidence of APC mutation. J Pathol 180:33-37, 1996.
10. Groden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589-600, 1991.
11. Su LK, Kinzler KW, Vogelstein B, et al. Multiple intestinal neoplasia caused by a mutation in the murine homologue of the APC gene. Science 256:668-670, 1992.
12. Kinzler KW, Nilbert MC, Vogelstein B, et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 25:1366-1370, 1991.
13. Rubinfield B, Albert I, Porfiri E, Fiol C, Munemitsu S. Polakis P. Binding of GSK3b to APC-β-catenin complex and regulation of complex assembly. Science 272:1023-1026, 1996.
14. Rubinfield B, Souza B, Albert I, et al. Association of the APC gene product with β-catenin. Science 262:1731-1733, 1993.
15. Su LK, Vogelstein B, Kinzler KW. Association of the APC tumor suppressor protein with catenins. Science 262:1734-1737, 1993.
16. Munemitsu S, Albert I, Souza B, Rubinfield B, Polakis P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 92:3046-3050, 1995.
17. Bôhm M, Totzeck B, Birchmeier W, Weiland I. Differences of Ecadherin expression levels and patterns in primary and metastatic human lung cancer. Clin Exp Metastasis 12:55-62, 1994.
18. Baeg G, Matsumine A, Kuroda T, et al. The tumor suppressor gene product ARC blocks cell cycle progression from GO/G1 to S phase. EMBO J 14:5618-5625, 1995.
19. Matsumine A, Ogai A, Senda T, et al. Binding of ARC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272:1020-1023, 1996.
20. Munemitsu S, Souza B, Muller O, Albert I, Rubinfield B, Polakis P. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res 54:3676-3681, 1994.
21. Kinzier KW, Nilbert MC, Su L, et al. Identification of FAP locus genes from chromosome 5q21. Science 253:661-664, 1991.
22. Bourne HR. Consider the coiled coil. Nature 351:188-190, 1991.
23. Matsumine A, Senda T, Baeg G. MCC, a cytoplasmic protein that blocks cell cycle progression from GO/G1 to S phase. J Biol Chem 271:10341-10346, 1996.
24. Justice MJ, Gilbert DJ, Kinzler KW, et al. Molecular genetic map of mouse chromosome 18 reveals extensive linkage conservation with human chromosome 5 and 18. Genomics 13:1281-1288, 1992.
25. Luongo C, Gould KA, Su L, et al. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of mouse. Genomtes 15:3-8, 1993.
26. Obata M, Nishimori H, Ogana K, Lee G-H. Identification of the Par2 (Pulmonary adenoma resistance) locus in mouse chromosome 18, a major genetic determinant for lung carcinogen 3resistance in BALB/cByJ mice. Oncogene 13:1599-1604, 1996.
27. Malkinson AM. Primary lung tumors in mice: An experimentally manipulate model of human adenocarcinoma. Cancer Res 52(suppl):2670s-2676s, 1992.
28. Malkinson AM, Belinsky SA. The use of animal models in pfeclinical studies. In: Pass HL, Mitchell J, Johnson DH, Turrisi AT (eds), Lung Cancer: Principles and Practice. JB Lippincott, Philadelphia, 1996, pp. 273-284.
29. INK4a-β in mouse lung tumor cells. Oncogene 13:1885-1891, 1996.
30. Herzog CR, Wiseman RW, You M. Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res 54:4007-4010, 1994.
31. Herzog CR, Wang Y, You M. Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36. Oncogene 11:1811-1815, 1995.
32. Horio Y, Schrump DS, Chen A, Rice P, Malkinson AM, Roth JA. Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice. Mol Carcinog 17:217-223, 1996.
33. Smith GJ, LeMesurier SM, De Montfort ML, Lykke AWJ. Development and characterization of type 2 pneumocyte-related cell lines from normal adult mouse lung. Pathology 16:401-405, 1984.
34. Smith GJ, Lykke AWJ. Characterization of a neoplastic epithelial cell strain derived by dexamethasone treatment of cultured normal mouse type 2 pneumocytes. J Pathol 147:165-172, 1985.
35. Parsa I, Kauffman SL. Malignant Clara cell line derived from ethylnitrosourea-induced murine lung adenoma. Cancer Lett 1:311-316, 1994.
36. Malkinson AM, Dwyer-Neild LD, Rice PL, Dinsdale D. Mouse lung epithelial cell lines: Tools for the study of differentiation and the neoplastic phenotype. Toxicology 123:53-100, 1997.
37. Wu M, Sundaresan V, Sundaresan M, Rabbitts PH. Genomewide search for genetic damage in p53 transgenic mouse lung tumors reveals consistent loss of chromosome 4. Eur J Cancer (in press).
38. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
39. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning: A Laboratory Manual. 1st ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1982, pp. 187-210.
40. Lange-Carter CA, Malkinson AM. Differential regulation of the stability of cyclic AMP-dependent protein kinase messenger RNA in normal versus neoplastic mouse lung epithelial cells. Cancer Res 51:6699-6703, 1991.
41. Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS. "Touchdown" PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 19:4008, 1991.
42. Sabath DE, Broome EH, Prystowsky MB. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene 91:185-191, 1990.
43. Hori A, Nakaatsuru S, Ichii S, Nagae H, Nakamura Y. Multiple forms of the APC gene transcripts and their tissue-specific expression. Hum Mol Genet 2:283-287, 1993.
44. Oshima M, Sugiyama H, Kitagawa K, Taketo M. APC gene messenger RNA: Novel isoforms that lack exon 7. Cancer Res 53:5589-5591, 1993.
45. Thliveris A, Samowitz W, Matsunami N, Groden J, White R. Demonstration of promoter activity and alternative splicing in the region 5′ to exon 1 of the APC gene. Cancer Res 54:2991-2995, 1994.
46. Santoro IM, Groden J. Alternative splicing of the APC gene and its association with terminal differentiation. Cancer Res: 488-498, 1997.
47. Groden J, Joslyn G, Samowitz W, et al. Response of colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene. Cancer Res 55:1531-1539, 1995.
48. Curtis U, Bubb VJ, Gledhill S, Morris RG, Bird CC, Wyllie AH. Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. Hum Mol Genet 3:443-146, 1994.
49. Boynton RF, Blount PL, Yin J, et al. Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc Natl Acad Sci USA 89:3385-3388, 1992.
50. Huang Y, Boynton RF, Blount PL, et al. Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers. Cancer Res 52:6525-6530, 1992.
51. Polakis P. Mutations in the ARC gene and their implications for protein structure and function. Curr Opin Genet Dev 5:66-71, 1995.
52. Béroud C, Soussi T. APC gene: Database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res 24:121-124, 1996.
53. Miyoshi Y, Nagase H, Ando H, et al. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APCgene. Hum Mol Genet 1:229-233, 1992.
54. Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247:322-324, 1991.
55. Nishisho I, Nakamura Y, Miyoshi Y, et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253:665-669, 1991.
56. Gao X, Zacharek A, Grignon D, et al. High frequency of loss of expression and allelic deletion of the APC and MCC genes in human prostate cancer. Int J Oncol 6:111-117, 1995.
57. Wilson VL, Wei Q, Miley FB, Malkinson AM. 5-Methyldeoxycytidine patterns and lung cancer susceptibility in mice. Proceedings of the American Association for Cancer Research 33:102, 1992.
58. Belinsky SA, Nikula KJ, Baylin SB, Issa J. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci USA 93:4045-4050, 1996.
59. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87:159-170, 1996.