A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax

Gene Therapy

Volumn 7, Issue 1, 2000, Pages 75-79

  Kagawa, S ^a   Pearson, S A ^a   Ji, L ^a   Xu, K ^a   McDonnell, T J ^a   Swisher, S G ^a   Roth, J A ^a   Fang, B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Apoptosis; bax gene; Cell death; Gene therapy

Indexed keywords

COMPLEMENTARY DNA; HYBRID PROTEIN; PROTEIN BAX; TRANSACTIVATOR PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CARCINOMA CELL; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; GENE TRANSFER; HUMAN; HUMAN CELL; LIVER CELL; LUNG CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TARGET CELL; TATA BOX;

ADENOVIRIDAE; ANIMALIA; MAMMALIA;

EID: 0033967137     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301048     Document Type: Article

References (15)

1. Kovesdi I et al. Adenoviral vectors for gene transfer. Curr Opin Biotech 1997; 8: 583-589.
2. Yeh P, Perricaudet M. Advances in adenoviral vectors: from genetic engineering to their biology. FASEB J 1997; 11: 615-623.
3. Larregina AT et al. FasL induces Fas/Apol-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors. Gene Therapy 1998; 5: 563-568.
4. Arai H, Gordon D, Nabel EG, Nabel GJ. Gene transfer of Fas ligand induces tumor regression in vivo. Proc Natl Acad Sci USA 1997; 94: 13862-13867.
5. Okuyama T et al. Efficient Fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system. Gene Therapy 1998; 5: 1047-1053.
6. Shinoura N et al. Construction, propagation, and titer estimation of recombinant adenoviruses carrying proapoptotic genes. Hum Gene Ther 1998; 9: 2683-2689.
7. Apte SS, Mattei MG, Olsen BR. Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta. Genomics 1995; 26: 592-594.
8. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.
9. Coll JL et al. Antitumor activity of bax and p53 naked gene transfer in lung cancer: in vitro and in vivo analysis. Hum Gene Ther 1998; 9: 2063-2074.
10. Fang B, Ji L, Bouvet M, Roth JA. Evaluation of GAL4/TATA in vivo. Induction of transgene expression by adenovirally mediated gene codelivery. J Biol Chem 1998; 273: 4972-4975.
11. Zhang WW et al. Generation and identification of recombinant adenovirus by liposome-mediated transfection and PCR analysis. Biotechniques 1993; 15: 868-872.
12. Fueyo J et al. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nature Med 1998; 4: 685-690.
13. Tewari M et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death subst-ate poly (ADP-ribose) polymerase. Cell 1995; 81: 801-809.
14. Lieber A et al. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J Virol 1997; 71: 8798-8807.
15. Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.