Plasma levels of artesunate and dihydroartemisinin in children with Plasmodium falciparum malaria in Gabon after administration of 50-milligram artesunate suppositories

American Journal of Tropical Medicine and Hygiene

Volumn 58, Issue 3, 1998, Pages 365-368

  Halpaap, Beatrice ^a   Ndjave, Maryse ^b   Paris, Maria ^a   Benakis, Achille ^a   Kremsner, Peter G ^b,c  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b ALBERT SCHWEITZER HOSPITAL   (Gabon)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; CHLOROQUINE; DIHYDROARTEMISININ; FANSIDAR;

ARTICLE; BODY TEMPERATURE; CLINICAL ARTICLE; CLINICAL PROTOCOL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG METABOLISM; FEMALE; FEVER; HUMAN; MALARIA FALCIPARUM; MALE; PARASITEMIA; PLASMODIUM FALCIPARUM; RECTAL DRUG ADMINISTRATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCHOOL CHILD; SUPPOSITORY;

EID: 0031900724     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1998.58.365     Document Type: Article

References (9)

1. Nosten F, Price RN, 1995. New antimalarials, a risk benefit analysis. Drug Saf (suppl 4): 264-273.
2. Hien TT, White NJ, 1993. Qinghaosu. Lancet 341: 603-608.
3. White NJ, 1994. Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives, Trans R Soc Trop Med Hyg 88 (suppl 1): 41-43.
4. Barradell LB, Fitton A, 1995. Artesunate, a review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs 50: 714-741.
5. Hermann TW, 1995. Recent research on bioavailability of drugs from suppositories. Int J Pharm 123: 1-11.
6. Li GQ, Guo XB, Jiang HX, Fu LC, 1990. Observations of the efficacy of qinghasu suppositories in 100 cases of falciparum malaria. Li GQ, Guo XB, Jiang HX, eds. Clinical Trials on Qinghaosu and its Derivatives. Volume 1. Guangzhou, China: College of Traditional Chinese Medicine, Sanya Tropical Medicine Institute, 78-81.
7. Li GQ, Guo XB, Jiang HX, Fu LC, 1990. A summary of clinical studies on the treatment of malaria with qinghaosu suppositories. Li GQ, Guo XB, Jiang HX, eds. Clinical Trials on Qinghaosu and its Derivatives. Volume 1. Guangzhou, China: College of Traditional Chinese Medicine, Sanya Tropical Medicine Institute, 17-22.
8. Benakis A, Paris M, Loutan L, Plessas CT, Plessas ST, 1996. Pharmacokinetics study of a new pharmaceutical form of artesunate (PLASMOTRIM® -200 RECTOCAPS®) administered in healthy volunteers by rectal route. Jpn J Trop Med Hyg 24 (suppl 1): 39-45.
9. Benakis A, Paris M, Loutan L, Plessas CT, Plessas ST, 1997. Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers. Am J Trop Med Hyg 56: 17-23.