Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 91, Issue 3, 1997, Pages 335-342

  Phuong, Cao Xuan Thanh ^a   Bethell, Delia B ^b,c   Phuong, Pham Tung ^b   Mai, Ta Thi Tuyet ^a   Thuy, Tran Thi Nhu ^a   Ha, Nguyen Thi Thanh ^a   Thuy, Pham Thi Thu ^a   Anh, Nguyen Thi Tuyet ^a   Day, Nicholas P J ^b,c   White, Nicholas J ^b,c,d  

^a Dong Nai Paediatric Centre   (Viet Nam)

^b CHO QUAN HOSPITAL   (Viet Nam)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Artemisinin suppositories; Chemotherapy; Children; Malaria; Plasmodium falciparum

Indexed keywords

ARTEMISININ; ARTESUNATE; FANSIDAR; MEFLOQUINE; PYRIMETHAMINE; QUININE; SULFADOXINE;

ADOLESCENT; ARTICLE; CARDIOTOXICITY; CHILD; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; EXTRASYSTOLE; FEMALE; HUMAN; INFANT; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MORTALITY; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION; RETICULOCYTE COUNT; SIDE EFFECT;

ARTESUNATE; CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM;

EID: 8244245260     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(97)90099-7     Document Type: Article

References (24)

1. Abd-El-Maeboud, K. H., El-Naggar, T., El-Hawi, E. M. M., Mahmoud, S. A. R. & Abd-El-Hawi, A. (1991). Rectal suppository: commonsense and mode of insertion. Lancet, 338, 798-800.
2. Anonymous (1992). Rediscovering wormwood: qinghaosu for malaria. Lancet, 339, 649-651.
3. Arnold, K. (1994). Early treatment of malaria in the community using artemisinin - hope or hazard? Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, supplement, S1/47-S1/49.
4. Bethell, D. B., Phuong, P. T., Phuong, C. X. T., Nosten, F., Waller, D., Davis, T. M. E., Day, N. P. J., Crawley, J., Brewster, D., Pukrittayakamee, S. & White, N. J. (1996). Electrocardiographic monitoring in severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 266-269.
5. Canfield, C. J. (1989). The development of arteether. In: Antimalarial Drug Development in China. Scientific Papers Presented at a Meeting of the Scientific Working Group on the Chemotherapy of Malaria held in Beijing on 24-26 April 1989,
6. Shen, J. X. (editor). Beijing: National Institute of Pharmaceutical Research and Development, on behalf of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), pp. 75-82.
7. Gibaldi, M. (1984). Biopharmaceutics and Clinical Pharmacokinetics, 3rd edition. Philadelphia: Lea & Febiger, pp. 104-109.
8. Hien, T. T. & White, N. J. (1993). Qinghaosu. Lancet, 341, 603-608.
9. Hien, T. T., Tam, D. T. H., Cuc, N. T. K. & Arnold, K. (1991). Comparative effectiveness of artemisinin suppositories and oral quinine in children with acute malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85, 210-211.
10. Hien, T. T., Arnold, K., Vinh, H., Cuong, B. M., Phu, N. H., Chau, T. T. H., Hoa, N. T. M., Chuong, L. V., Mai, N. T. H., Vinh, N. N. & Trang, T. T. M. (1992). Comparison of artemisinin suppositories with intravenous quinine in the treatment of cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 582-583.
11. Li, G. Q., Guo, X. B., Jiang, H. X., Fu, L. C., Shen, L., Li, R. S., Dai, B. Q. & Li, Z. L. (1985). Observation on the efficacy of quinghaosu suppository in 100 cases of falciparum malaria. Journal of Traditional Chinese Medicine, 5, 159-161.
12. Li, G. Q., Guo, X. B. & Yang, F. (editors) (1990). Clinical Trials of Qinghaosu and its Derivatives. Guangzhou: College of Traditional Chinese Medicine, Sanya Tropical Medical Institute, vol. 1, pp. 1-90.
13. Li, G.-Q., Guo, X.-B., Fu, L.-C., Jian, H.-X. & Wang, X.-H. (1994). Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, supplement, S1/5-S1/6.
14. Molyneux, M. E. & Taylor, T. E. (1989). Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Quarterly Journal of Medicine, 71, 441-459.
15. Phillips, R. E., Loowareesuwan, S.,Warrell, D. A., Lee, S. H., Karbwang, J., Warrell, M. J., White, N. J., Swasdichai, C. & Weatherall, D. J. (1986). The importance of anaemia in cerebral and uncomplicated falciparum malaria: role of complications, dyserythropoiesis and iron sequestration. Quarterly Journal of Medicine, 58, 305-323.
16. Schapira, A., Solomon, T., Julien, M., Macome, A., Parmar, N., Ruas, I., Simão, F., Streat, E. & Betschart, B. (1993). Comparison of intramuscular and intravenous quinine for the treatment of severe and complicated malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 87, 299-302.
17. Silamut, K., Hough, R., Eggelte, T., Pukrittayakamee, S., Angus, B. & White, N. J. (1995). A simple method for assessing quinine pre-treatment in acute malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 655-667.
18. Titulaer, H. A. C., Zuidema, J., Kager, P. F., Wetsteyn, J. C. F. M., Lugt, C. H. B. & Merkus, F. W. H. M. (1990).The pharmacokinetics of artemisinin after oral, intramuscular, and rectal administration to human volunteers. Journal of Pharmacy and Pharmacology, 42, 810-813.
19. WHO (1990). Severe and complicated malaria, 2nd edition. Transactions of the Royal Society of Tropical Medicine and Hy-giene, 84, Supplement 2.
20. White, N. J. & Silamut, K. (1989). Rapid diagnosis of malaria. Lancet, i, 435.
21. White, N. J., Warrell, D. A., Chanthavanich, P., Looareesuwan, S., Warrell, M. J., Krishna, S., Williamson, D. H. & Turner, R. C. (1983). Severe hypoglycemia and severe hyperinsulinemia in falciparum malaria. New England Journal of Merdicine, 309, 61-66.
22. White, N. J., Marsh, K., Turner, R. C., Miller, K. D., Berry, C. D., Williamson, D. H. & Brown, J. (1987). Hypoglycaemia in African children with severe malaria. Lancet, i, 708-711.
23. White, N. J., Phillips, R. E., Looareesuwan, S., Chanthavanich, P. & Warrell, D. A. (1988). Single dose phenobarbitone prevents convulsions in cerebral malaria. Lancet, ii, 64-66.
24. Yen, L. M., Dao, L. M., Day, N. P. J., Waller, D. J., Bethell, D. B., Son, L. H., Hien, T. T. & White, N. J. (1994). Role of quinine in the high mortality of intramuscular injection tetanus. Lancet, 344, 786-787.