The effect of aloe emodin on the proliferation of a new Merkel carcinoma cell line

American Journal of Dermatopathology

Volumn 24, Issue 1, 2002, Pages 17-22

  Wasserman, Lina ^a   Avigad, Smadar ^a   Beery, Einat ^a   Nordenberg, Jardena ^a   Fenig, Eyal ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

Aloe emodin; Differentiating agents; Dimethyl sulfoxide; Merkel cell carcinoma; Sodium butyrate

Indexed keywords

ALOE EMODIN; BASIC FIBROBLAST GROWTH FACTOR; BUTYRIC ACID; CALCITONIN; CHROMOGRANIN A; CYTOKERATIN 20; DIMETHYL SULFOXIDE; EPIDERMAL GROWTH FACTOR; EPITHELIAL MEMBRANE ANTIGEN; GROWTH FACTOR; NERVE GROWTH FACTOR; NEUROFILAMENT PROTEIN; NEURON SPECIFIC ENOLASE; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA;

AGED; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CERVICAL LYMPH NODE; CHROMOSOME 10; CHROMOSOME 3; CHROMOSOME 7; CHROMOSOME LOSS; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; GENE DELETION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KARYOTYPE; MALE; MERKEL CELL TUMOR; METASTASIS; ONCOGENE; PHYTOTHERAPY; PRIORITY JOURNAL; TP53 GENE;

AGED; ANTINEOPLASTIC AGENTS; BUTYRATES; CARCINOMA, MERKEL CELL; CELL DIVISION; CHROMOSOME ABERRATIONS; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMODIN; GROWTH SUBSTANCES; HUMANS; IMMUNOENZYME TECHNIQUES; KARYOTYPING; MALE; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0036159324     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000372-200202000-00003     Document Type: Article

References (43)

1. Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?
2. Merkel cell carcinoma
3. Merkel cells and Merkel cell tumors: Ultrastructure, immunocytochemistry and review of literature
4. Merkel cell carcinoma: Histopathology, immunohistochemistry and cytogenetic analysis
5. Characterisation of four Merkel cell carcinoma adherent cell lines
6. Merkel cell carcinoma. Review of 22 cases with surgical, pathologic and therapeutic considerations
7. A study of apoptosis in Merkel cell carcinoma: An immunohistochemical, ultrastructural, DNA ladder, and TUNEL labeling study
8. Peripherin, a neuronal intermediate protein, is stably expressed by neuroendocrine carcinomas of the skin, their xenograft on nude mice, and the corresponding primary cultures
9. Merkel cell carcinoma. Squamous and atypical fibroxanthoma-like differentiation in successive local tumor recurrences
10. Merkel cell carcinoma: Report of ten cases with emphasis on clinical course, treatment, and in vitro drug sensitivity
11. Chromosomal evolution in a Merkel cell carcinoma
12. The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma
13. Radiation sensitivity of Merkel cell carcinoma cell lines
14. Farnesylthio- salicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice
15. Chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma
16. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors
17. Multicolor spectral karyotyping of human chromosomes
18. Infrequent p53 mutation and mdm-2 gene amplification in childhood brain tumors
19. A novel germ-line mutation in the noncoding region of the p53 gene in a Li-Fraumeni family
20. A study of some of the variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity
21. Cytokeratin 20: A marker for diagnosing Merkel cell carcinoma
22. Cytokeratin and neurofilament protein staining in Merkel cell carcinoma of the small cell type and small cell carcinoma of the lung
23. Establishment and characterization of two Merkel cell tumor cultures
24. Diagnostic relevance of chromosomal in-situ hybridization in Merkel cell carcinoma: Targeted interphase cytogenetic tumour analyses
25. Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization
26. Molecular analysis of 1p36 breakpoints in two Merkel cell carcinomas
27. Genetic changes associated with primary Merkel cell carcinoma
28. Mutation analysis of P73 and TP53 in Merkel cell carcinoma
29. Trabecular carcinoma of the skin
30. Basic fibroblast growth factor potentiates cisplatinum-induced cytotoxicity in MCF-7 human breast cancer cells
31. TGF-β receptor signaling
32. Nerve growth factor: Its significance in cutaneous biology
33. Overexpression of brain-derived neurotrophic factor increases Merkel cell number in murine skin
34. Characterization of cell lines established from Merkel cell (small-cell) carcinoma of the skin
35. Growth inhibition of murine melanoma by butyric acid and dimethylsulfoxide
36. Differential effects of sodium butyrate and dimethylsulfoxide on gamma-glutamyl transpeptidase and alkaline phosphatase activities in MCF-7 breast cancer cells
37. Butyric acid and pivaloyloxymethyl butyrate. AN-9, a novel butyric acid derivative induce apoptosis in HL-60 cells
38. Sodium butyrate enhances the activities of membranal enzymes and increases drug sensitivity in a cell line from ascitic fluid of an ovarian carcinoma patient
39. Influence of aloe vera on collagen characteristics in healing dermal wounds in rats
40. Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms
41. The therapeutic potential of aloe vera in tumor-bearing rats
42. Effect of anthraquinone-laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells
43. Genotoxicity of aloe emodin in vitro and in vivo