Basic fibroblast growth factor potentiates cisplatinum-induced cytotoxicity in MCF-7 human breast cancer cells

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 10, 1999, Pages 556-562

  Fenig, E ^a   Livnat, T ^a   Sharkon Polak, S ^b   Wasserman, L ^a   Beery, E ^a   Lilling, G ^b   Yahalom, J ^c   Wieder, R ^d   Nordenberg, J ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Basic fibroblast growth factor; Bcl 2; Cisplatinum; MCF 7

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CISPLATIN; DNA FRAGMENT; PROTEIN BCL 2;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL SEPARATION; CISPLATIN; DNA, NEOPLASM; DRUG SYNERGISM; FEMALE; FIBROBLAST GROWTH FACTOR 2; FLOW CYTOMETRY; HUMANS; MICROSCOPY, ELECTRON; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 0032883952     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050316     Document Type: Article

References (22)

1. Briozzo P, Badet J, Capony F, Peiri I, Montcourrier P, Barritault D, Rochefort H (1991) MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D. Exp Cell Res 194:252-259
2. Decaudin D, Geley S, Hirsch T, Castedo M, Marchetti P, Macho A, Kofler R, Kroemer G (1997) Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57:62-67
3. Dole M, Nunez G, Merchant AK, Maybaum J, Rode CK, Bloch CA, Castle VP (1994) Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res 54:3253-3259
4. Fenig E, Wieder R, Paglin S, Wang H, Persaud R, Haimovitz-Friedman A, Fuks Z, Yahalom J (1997) Basic fibroblast growth factor confers growth inhibition and ERK activation in human breast cancer cells. Clin Cancer Res 3:135-142
5. Fuks Z, Persaud RS, Alfieri A, McLoughlin A, Schwartz JL, Seddon A, Haimovitz-Friedman A (1994) Basic fibroblast growth factor protects endothelial cells from radiation-induced programmed cell death in vitro and in vivo. Cancer Res 54:2582-2590
6. Givol D, Yayon A (1992) Complexity of FGF receptors: Genetic basis for structural diversities and functional specificity. FASEB J 6:3362-3369
7. Gospodarowicz D, Moran J, Braun D, Birdwell C (1976) Clonal growth of bovine vascular endothelial cells: Fibroblast growth factor as a survival agent. Proc Natl Acad Sci USA 73:4120-4124
8. Karey KP, Sirbasku DA (1988) Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17β-estradiol. Cancer Res 48:4083-4092
9. Martin SJ, Green DR (1994) Apoptosis as a goal of cancer therapy. Curr Opin Oncol 6:616-621
10. McLeskey SW, Ding IYF, Lippman ME, Kern FG (1994) MDA-MB-134 breast carcinoma cells overexpressed fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands. Cancer Res 54:523-530
11. Miyake H, Hara I, Gohji K, Yoshimura K, Avakawa S, Kamidono S (1998) Expression of basic fibroblast growth factor is associated with resistance to cisplatin in a human bladder cancer cell line. Cancer Lett 123:121-126
12. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodine and flow cytometry. J Immunol Methods 139:271-279
13. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
14. Polak-Charcon S, Hekmati M, Ben Shaul Y (1989) The effect of modifying the culture medium on cell polarity in a human colon carcinoma cell line. Cell Differ Dev 26:119-129
15. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6
16. Rifkin DB, Moscatelli D (1989) Recent developments in the cell biology of basic fibroblast growth factor. J Cell Biol 109:1-6
17. Sakakura C, Sweeney EA, Shirahama T, Igarashi Y, Hakamuri S, Nakatani H, Tsujimoto H, Imanishi T, Ohgaki M, Ohyama T, Yamazaki J, Haigwara A, Yamaguchi T, Sawai K, Takahashi T (1996) Overexpression of Bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int J Cancer 67:101-105
18. Simonian PL, Grillot DA, Numez G (1997) Bcl-2 and Bcl-XL can differentially block chemotherapy-induced death. Blood 90:1208-1216
19. Skehan P, Storeng R, Scudigro D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990) New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst 82:1107-1112
20. Wang H, Rubin M, Fenig E, DeBlasio A, Mendelson J, Yahalom J, Wieder R (1997) Basic fibroblast growth factor causes growth arrest in MCF-7 human breast cancer cells while inducing both mitogenic and inhibitory G1 events. Cancer Res 57:1750-1751
21. Wang Q, Maloof P, Wang H, Fenig E, Stein D, Nichols G, Denny TN, Yahalom J, Wieder R (1998) Basic fibroblast growth factor (bFGF) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. Exp Cell Res 238:177-187
22. Wieder R, Fenig E, Wang H, Paglin S, Wang Q, Menzel T, Gabrilov J, Fuks Z, and Yahalom J (1998) Overexpression of basic fibroblast growth factor in MCF-7 human breast cancer cells: Lack of correlation between inhibition of cell growth and MAP kinase activation. J Cell Physiol 177:411-425