FHL-1/reconectin and factor H: Two human complement regulators which are encoded by the same gene are differently expressed and regulated

Molecular Immunology

Volumn 36, Issue 13-14, 1999, Pages 809-818

  Friese, Manuel A ^a   Hellwage, Jens ^b   Jokiranta, T Sakari ^b   Meri, Seppo ^b   Peter, Hans H ^c   Eibel, Hermann ^c   Zipfel, Peter F ^a,d  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF FREIBURG   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Alternative splicing; Cancer; Complement; Complement regulation; Rheumatoid arthritis

Indexed keywords

COMPLEMENT FACTOR H;

ALTERNATIVE RNA SPLICING; ANTIGEN ANTIBODY COMPLEX; CARBOXY TERMINAL SEQUENCE; COMPLEMENT ACTIVATION; CONFERENCE PAPER; EFFECTOR CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC CODE; GENETIC REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA PROCESSING; TISSUE INJURY; TRANSCRIPTION REGULATION;

ARTHRITIS, RHEUMATOID; BLOOD PROTEINS; COMPLEMENT FACTOR H; GENE EXPRESSION REGULATION; HUMANS; LIVER; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 0033384014     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(99)00101-7     Document Type: Conference Paper

References (61)

1. Bjørge L., Vedeler C.A., Ulvestad E., Matre R. Expression and function of CD59 on colonic adenocarcinoma cells. Eur. J. Immunol. 24:1994;1597-1603.
2. Brodeur J.P., Ruddy S., Schwartz L.B., Moxley G. Synovial fluid levels of complement SC5b-9 and fragment Bb are elevated in patients with rheumatoid arthritis. Arthritis Rheum. 34:1991;1531-1537.
3. Brooimans R.A., Hiemstra P.S., van der Ark A.A., Sim R.B., van Es L.A., Daha M.R. Biosynthesis of complement factor H by human umbilical vein endothelial cells. Regulation by T cell growth factor and IFN-gamma. J. Immunol. 142:1989;2024-2030.
4. Corvetta A., Pomponio G., Rinaldi N., Luchetti M.M., Di Loreto C., Stramazzotti D. Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma. Clin. Exp. Rheumatol. 10:1992;433-438.
5. de Ceulaer C., Papazoglou S., Whaley K. Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and synovial membrane cells from patients with rheumatoid arthritis. Immunology. 41:1980;37-43.
6. Diaz-Guillen M.A., Rodriguez de Cordoba S., Heine-Suner D. A radiation hybrid map of complement factor H and factor H-related genes. Immunogenetics. 49:1999;549-552.
7. Erdei A., Julen N., Marschang P., Feifel E., Kerekes K., Dierich M.P. A novel, complement factor H-related regulatory protein expressed on the surface of human B cell lines. Eur. J. Immunol. 24:1994;867-872.
8. Fearon D.T. Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway. Proc. Natl. Acad. Sci. USA. 75:1978;1971-1975.
9. Feldmann M., Brennan F.M., Maini R.N. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14:1996;397-440.
10. Friese M.A., Hellwage J., Jokiranta T.S., Meri S., Peter H.H., Eibel H., Zipfel P.F. Different transcriptional regulation and expression of members of the factor H family by inflammatory mediators and in rheumatoid arthritis. Mol. Immunol. 36:1999;28.
11. Gasque P., Julen N., Ischenko A.M., Picot C., Mauger C., Chauzy C., Ripoche J., Fontaine M. Expression of complement components of the alternative pathway by glioma cell lines. J. Immunol. 149:1992;1381-1387.
12. Gasque P., Fontaine M., Morgan B.P. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J. Immunol. 154:1995;4726-4733.
13. Gasque P., Morgan B.P. Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes. Immunology. 89:1996;338-347.
14. Gasque P., Thomas A., Fontaine M., Morgan B.P. Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins. J. Neuroimmunol. 66:1996;29-40.
15. Goodfellow R.M., Williams A.S., Levin J.L., Williams B.D., Morgan B.P. Local therapy with soluble complement receptor 1 (sCR1) suppresses inflammation in rat mono-articular arthritis. Clin. Exp. Immunol. 110:1997;45-52.
16. Guc D., Gulati P., Lemercier C., Lappin D., Birnie G.D., Whaley K. Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium. Rheumatology International. 13:1993;139-146.
17. Hanauske-Abel H.M., Pontz B.F., Schorlemmer H.U. Cartilage specific collagen activates macrophages and the alternative pathway of complement: evidence for an immunopathogenic concept of rheumatoid arthritis. Ann. Rheum. Dis. 41:1982;168-176.
18. Heicappell R., Wettig I.C., Schostak M., Muller M., Steiner U., Sauter T., Miller K. Quantitative detection of human complement factor H-related protein in transitional cell carcinoma of the urinary bladder. Eur. Urol. 35:1999;81-87.
19. Heine-Suner D., Diaz-Guillen M.A., de Villena F.P., Robledo M., Benitez J., Rodriguez de Cordoba S. A high-resolution map of the regulator of the complement activation gene cluster on 1q32 that integrates new genes and markers. Immunogenetics. 45:1997;422-427.
20. Hellwage J., Kühn S., Zipfel P.F. The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity. Biochem. J. 326:1997;321-327.
21. Høgåsen K., Mollnes T.E., Harboe M., Götze O., Hammer H.B., Oppermann M. Terminal complement pathway activation and low lysis inhibitors in rheumatoid arthritis synovial fluid. J. Rheumatol. 22:1995;24-28.
22. Irani J., Desgrandchamps F., Millet C., Toubert M.E., Bon D., Aubert J., Le Duc A. BTA stat and BTA TRAK: a comparative evaluation of urine testing for the diagnosis of transitional cell carcinoma of the bladder. Eur. Urol. 35:1999;89-92.
23. Johnsson E., Berggård K., Kotarsky H., Hellwage J., Zipfel P.F., Sjöbring U., Lindahl G. Role of the hypervariable region in streptococcal M proteins: binding of a human complement inhibitor. J. Immunol. 161:1998;4894-4901.
24. Junnikkala S., Jokiranta T.S., Friese M.A., Zipfel P.F., Meri S. Endogenous secretion of factor H and Factor H-like protein 1 confer exceptional complement resistance to human H2 glioblastoma cells. Mol. Immunol. 36:1999;315.
25. Katz Y., Guterman M., Lahat E. Regulation of synthesis of complement proteins in HEp2 cells. Clin. Immunol. Immunopathol. 67:1993;117-123.
26. Katz Y., Strunk R.C. Synthesis and regulation of complement protein factor H in human skin fibroblasts. J. Immunol. 141:1988;559-563.
27. Kinders R., Jones T., Root R., Bruce C., Murchison H., Corey M., Williams L., Enfield D., Hass G.M. Complement factor H or a related protein is a marker for transitional cell cancer of the bladder. Clin. Cancer Res. 4:1998;2511-2520.
28. Kotarsky, H., Hellwage, J., Johnsson, E., Skerka, C., Svensson, H.G., Lindahl, G., Sjöbring, U., Zipfel, P.F., 1998. Identification of a domain in human factor H and factor H-like protein 1 required for the interaction with streptococcal M proteins. 160, 3349-3354.
29. Kühn S., Skerka C., Zipfel P.F. Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1. J. Immunol. 155:1995;5663-5670.
30. Kühn S., Zipfel P.F. Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H. Eur. J. Immunol. 26:1996;2383-2387.
31. Lachmann P.J. The control of homologous lysis. Immunol. Today. 12:1991;312-315.
32. Lappin D.F., Whaley K. Interferon-induced transcriptional and post-transcriptional modulation of factor H and C4 binding-protein synthesis in human monocytes. Biochem. J. 271:1990;767-772.
33. Legoedec J., Gasque P., Jeanne J.F., Fontaine M. Expression of the complement alternative pathway by human myoblasts in vitro: biosynthesis of C3, factor B, factor H and factor I. Eur. J. Immunol. 25:1995;3460-3466.
34. Lemercier C., Julen N., Coulpier M., Dauchel H., Ozanne D., Fontaine M., Ripoche J. Differential modulation by glucocorticoids of alternative complement protein secretion in cells of the monocyte/macrophage lineage. Eur. J. Immunol. 22:1992;909-915.
35. Mäenpää A., Junnikkala S., Hakulinen J., Timonen T., Meri S. Expression of complement membrane regulators membrane cofactor protein (CD46), decay accelerating factor (CD55), and protectin (CD59) in human malignant gliomas. Am. J. Pathol. 148:1996;1139-1152.
36. Malhotra V., Sim R.B. Expression of complement factor H on the cell surface of the human monocytic cell line U937. Eur. J. Immunol. 15:1985;935-941.
37. Meri S., Pangburn M.K. Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H. Proc. Natl. Acad. Sci. USA. 87:1990;3982-3986.
38. Minta J.O. Regulation of complement factor H synthesis in U-937 cells by phorbol myristate acetate, lipopolysaccharide, and IL-1. J. Immunol. 141:1988;1630-1635.
39. Misasi R., Huemer H.P., Schwaeble W., Solder E., Larcher C., Dierich M.P. Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement. Eur. J. Immunol. 19:1989;1765-1768.
40. Morgan B.P., Daniels R.H., Williams B.D. Measurement of terminal complement complexes in rheumatoid arthritis. Clin. Exp. Immunol. 73:1988;473-478.
41. Morgan B.P., Meri S. Membrane proteins that protect against complement lysis. Springer Semin. Immunopathol. 15:1994;369-396.
42. Morris K.M., Aden D.P., Knowles B.B., Colten H.R. Complement biosynthesis by the human hepatoma-derived cell line HepG2. J. Clin. Invest. 70:1982;906-913.
43. Müller-Eberhard H.J., Schreiber R.D. Molecular biology and chemistry of the alternative pathway of complement. Adv. Immunol. 29:1980;1-53.
44. Pangburn M.K., Schreiber R.D., Müller-Eberhard H.J. Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J. Exp. Med. 146:1977;257-270.
45. Pangburn M.K., Müller-Eberhard H.J. Complement C3 convertase: cell surface restriction of beta1H control and generation of restriction on neuraminidase-treated cells. Proc. Natl. Acad. Sci. USA. 75:1978;2416-2420.
46. Ripoche J., Mitchell J.A., Erdei A., Madin C., Moffatt B., Mokoena T., Gordon S., Sim R.B. Interferon gamma induces synthesis of complement alternative pathway proteins by human endothelial cells in culture. J. Exp. Med. 168:1988;1917-1922.
47. Schreiber R.D., Pangburn M.K., Lesavre P.H., Müller-Eberhard H.J. Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins. Proc. Natl. Acad. Sci. USA. 75:1978;3948-3952.
48. Schwaeble W., Zwirner J., Schulz T.F., Linke R.P., Dierich M.P., Weiss E.H. Human complement factor H: expression of an additional truncated gene product of 43 kDa in human liver. Eur. J. Immunol. 17:1987;1485-1489.
49. Schwaeble W., Schwaiger H., Brooimans R.A., Barbieri A., Most J., Hirsch-Kauffmann M., Tiefenthaler M., Lappin D.F., Daha M.R., Whaley K. Human complement factor H. Tissue specificity in the expression of three different mRNA species. Eur. J. Biochem. 198:1991;399-404.
50. Sim R.B., Kolble K., McAleer M.A., Dominguez O., Dee V.M. Genetics and deficiencies of the soluble regulatory proteins of the complement system. Int. Rev. Immunol. 10:1993;65-86.
51. Thomas L., Leyh H., Marberger M., Bombardieri E., Bassi P., Pagano F., et al. Multicenter trial of the quantitative BTA TRAK assay in the detection of bladder cancer. Clin. Chem. 45:1999;472-477.
52. van den Dobbelsteen M.E., Verhasselt V., Kaashoek J.G., Timmerman J.J., Schroeijers W.E., Verweij C.L., et al. Regulation of C3 and factor H synthesis of human glomerular mesangial cells by IL-1 and interferon-gamma. Clin. Exp. Immunol. 95:1994;173-180.
53. Vastag M., Skopal J., Kramer J., Kolev K., Voko Z., Csonka E., et al. Endothelial cells cultured from human brain microvessels produce complement proteins factor H, factor B, C1 inhibitor, and C4. Immunobiology. 199:1998;5-13.
54. Vik D.P., Keeney J.B., Munoz-Canoves P., Chaplin D.D., Tack B.F. Structure of the murine complement factor H gene. J. Biol. Chem. 263:1988;16,720-16,724.
55. Ward H.M., Higgs N.H., Blackmore T.K., Sadlon T.A., Gordon D.L. Cloning and analysis of the human complement factor H gene promoter. Immunol. Cell Biol. 75:1997;508-510.
56. Weiler J.M., Daha M.R., Austen K.F., Fearon D.T. Control of the amplification convertase of complement by the plasma protein beta1H. Proc. Natl. Acad. Sci. USA. 73:1976;3268-3272.
57. Whaley K., Ruddy S. Modulation of the alternative complement pathways by beta 1 H globulin. J. Exp. Med. 144:1976;1147-1163.
58. Williams S.A., Vik D.P. Characterization of the 5′ flanking region of the human complement factor H gene. Scand. J. Immunol. 45:1997;7-15.
59. Yamakawa M., Yamada K., Tsuge T., Ohrui H., Ogata T., Dobashi M., Imai Y. Protection of thyroid cancer cells by complement-regulatory factors. Cancer. 73:1994;2808-2817.
60. Zipfel P.F., Skerka C. Complement factor H and related proteins: an expanding family of complement-regulatory proteins? Immunol. Today. 15:1994;121-126.
61. Zipfel P.F., Skerka C. FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function. Immunol. Today. 20:1999;135-140.