Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and Factor H

European Journal of Immunology

Volumn 31, Issue 6, 2001, Pages 1674-1684

  Kraiczy, Peter ^a   Skerka, Christine ^b   Kirschfink, Michael ^c   Brade, Volker ^a   Zipfel, Peter F ^a,d  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c HANS KNÖLL INSTITUTE   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Borreliae; Complement; Factor H; Immune evasion; Innate immunity

Indexed keywords

BACTERIAL TOXIN; BINDING PROTEIN; COMPLEMENT; COMPLEMENT FACTOR H; LIGAND; MEMBRANE COFACTOR PROTEIN; MEMBRANE PROTEIN; RECONECTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; BACTERIUM ISOLATE; BORRELIA AFZELII; BORRELIA BURGDORFERI; BORRELIA GARINII; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; COMPLEMENT ACTIVATION; COMPLEMENT FACTOR; CONSENSUS SEQUENCE; CONTROLLED STUDY; DELETION MUTANT; EXPOSURE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SPECIES DIFFERENCE;

ADSORPTION; BACTERIAL PROTEINS; BINDING SITES; BLOOD PROTEINS; BORRELIA BURGDORFERI GROUP; COMPLEMENT ACTIVATION; COMPLEMENT C3B; COMPLEMENT FACTOR H; HUMANS; LYME DISEASE;

EID: 0034977067     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200106)31:6<1674::AID-IMMU1674>3.0.CO;2-2     Document Type: Article

References (33)

1. Innate immune recognition: Mechanisms and pathways
2. C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
3. Identification of a domain in human Factor H and Factor H-like protein-1 required for the interaction with streptococcal M proteins
4. Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein Factor H
5. The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis
6. A novel sialic acid binding site on Factor H mediates serum resistance of sialylated Neisseria gonorrhoeae
7. Complement evasion by Echinococcus granulosus: Sequestration of host Factor H in the hydatid cyst wall
8. Role of Yad A protein in prevention of opsonization of Yersinia enterocolitica by C3b molecules
9. Role of complement in HIV infection
10. Human complement regulators: A major target for pathogenic microorganisms
11. Factor H and disease: A complement regulator affects vital body functions
12. Binding of complement factor H to loop 5 of prin protein 1A: A molecular mechanisms of serum resistance of nonsialylated Neisseria gonorrhoeae
13. Role of the hypervariable region in streptococcal M proteins: Binding of a human complement inhibitor
14. FHL-1/reconectin: A human complement and immune regulator with cell-adhesive function
15. FHL-1/reconectin and factor H: Two human complement regulators which are encoded by the same gene are differently expressed and regulated
16. Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H
17. Identification of complement regulatory domains in human factor H
18. Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H
19. Lyme disease N
20. Differences of two Borrelia burgdorferi strains in complement activation and serum resistance
21. Heterogeneity in the complement-dependent bacteriolysis within the species of Borrelia burgdorferi
22. Complement-mediated serum sensitivity among spirochetes that cause Lyme disease
23. Comparison of two laboratory methods for the determination of serum resistance in Borrelia burgdorferi isolates
24. Borreliacidal activity of early Lyme disease sera against complement-resistant Borrelia afzelii FEM1 wild-type and an OspC-laking FEM1 variant
25. Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi
26. European Borrelia burgdorferi isolated from humans and ticks culture conditions and antibiotic susceptibility
27. The baculovirus expression vector pBSV-8His directs secretion of histidine-tagged proteins
28. The factor H-related proteins FHR-3 and FHR-4 represent ligands for the third component of complement
29. Characterization of outer membranes isolated from Borrelia burgdorferi, the Lyme disease spirochete
30. The factor H protein family
31. M protein of the group A streptococcus binds the seventh short consensus repeat of human complement factor H
32. Assessment of the interaction of human complement regulatory proteins with group A streptococcus: Identification of a high affinity group A Streptococcus binding site in FHL-1