Sphingosine-1-phosphate: A lipid second messenger regulating cell growth and survival

Journal of Liposome Research

Volumn 8, Issue 2, 1998, Pages 135-145

  Van Brooklyn, James R ^a   Cuvillier, Olivier ^a   Olivera, Ana ^a   Spiegel, Sarah ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell growth; Signal transduction; Sphingosine 1 phosphate

Indexed keywords

CERAMIDE; MEMBRANE LIPID; SPHINGOSINE 1 PHOSPHATE;

ANIMAL CELL; APOPTOSIS; CELL GROWTH; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; ENZYME ACTIVITY; ENZYME METABOLISM; LIPID METABOLISM; MITOGENESIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0031806250     PISSN: 08982104     EISSN: None     Source Type: Journal    
DOI: 10.3109/08982109809035522     Document Type: Review

References (61)

1. Hannun, Y. A. (1994) The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269: 3125-3128.
2. Kolesnick, R., and Golde, D., W. (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77: 325-328.
3. Hannun, Y. (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274: 1855-1859.
4. Spiegel, S., and Milstien, S. (1995) Sphingolipid metabolites: members of a new class of lipid second messengers. J. Membr. Biol. 146: 225-237.
5. Spiegel, S., Foster, D., and Kolesnick, R. (1996) Signal transduction through lipid second messengers. Curr. Opin. Cell Biol. 8: 159-167.
6. Merrill, A. H., Jr., Schmelz, E.-M., Dillehay, D. L., Spiegel, S., Shayman, J. A., Schroeder, J. J., Riley, R. T., Voss, K. A., and Wang, E. (1997) Sphingolipids-The enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142: 208-225.
7. Heller, R. A., and Kronke, M. (1994) Tumor necrosis factor receptor-mediated signaling pathways. J. Cell Biol. 126: 5-9.
8. Haimovitz-Friedman, A., Kan, C. C., Ehleiter, D., Persaud, R. S., McLoughlin, M., Fuks, Z., and Kolesnick, R. (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180: 525-535.
9. Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S., Nishioka, W., Brunner, T., Baier, G., Baier-Bitterlich, G., Byrd, C., Lang, F., Kolesnick, R., Altman, A., and Green, D. (1995) FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 2: 341-351.
10. Santana, P., Peña, L. A., Haimovitz-Friedman, A., Martin, S., Green, D., McLoughlin, M., Cordon-Cardo, C., Schuchman, E. H., Fuks, Z., and Kolesnick, R. (1996) Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86: 189-199.
11. Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. N. (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79.
12. Gomez-Munoz, A., Waggoner, D. W., O'Brien, L., and Brindley, D. N. (1995) Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phosphlipase D activity. J. Biol. Chem. 270: 26318-26325.
13. Pyne, S., Chapman, J., Steele, L., and Pyne, N. J. (1996) Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle cells. Eur. J. Biochem. 237: 819-826.
14. Coroneos, E., Martinez, M., McKenna, S., and Kester, M. (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J. Biol. Chem. 270: 23305-23309.
15. Bornfeldt, K. E., Graves, L. M., Raines, E. W., Igarashi, Y., Wayman, G., Yamamura, S., Yatomi, Y., Sidhu, J. S., Krebs, E. G., Hakomori, S., and Ross, R. (1995) Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J. Cell Biol. 130: 193-206.
16. Törnquist, K., Saarinen, P., Vainio, M., and Ahlström, M. (1997) Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells. Endocrinology 138:4049-4057.
17. Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brooker, G., and Spiegel, S. (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol. 114: 155-167.
18. Su, Y., Rosenthal, D., Smulson, M., and Spiegel, S. (1994) Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts. J. Biol. Chem. 269: 16512-16517.
19. Olivera, A., and Spiegel, S. (1993) Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and PCS mitogens. Nature 365: 557-560.
20. Spiegel, S., Olivera, A., Zhang, H., Thompson, E. W., Su, Y., and Berger, A. (1994) Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells. Breast Cancer Res. Treat. 31: 337-348.
21. Sadhira, Y., Ruan, F., Hakomori, S., and Igarashi, Y. (1992) Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. USA 89: 9686-9690.
22. Yatomi, Y., Ruan, F., Hakomori, S., and Igarashi , Y. (1995) Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. Blood 86: 193-202.
23. Postma, F. R., Jalink, K., Hengeveld, T., and Moolenaar, W. H. (1996) Sphingosine-1-phosphate rapidly induces rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J. 15: 2388-2392.
24. van Koppen, C. J., Meyer zu Heringdorf, D., Laser, K. T., Zhang, C., Jakobs, K. H., Bünnemann, M., and Pott, L. (1996) Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J. Biol. Chem. 271: 2082-2087.
25. Olivera, A., Rosenthal, J., and Spiegel, S. (1996) Effect of acidic phospholipids on Sphingosine kinase. J. Cell. Biochem. 60: 529-537.
26. van Veldhoven, P. P., and Mannaerts, G. P. (1991) Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. J. Biol. Chem. 266: 12502-12507.
27. van Veldhoven, P. P., and Mannaerts, G. P. (1994) Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: Evidence for the existence of a Sphingosine phosphatase. Biochem. J. 299: 597-601.
28. Mandala, S., Thornton, R., Tu, Z., Kurtz, M., Nickels, J., Broach, J., Menzeleev, R., and Spiegel, S. (1997) Sphingoid base 1-phosphate phosphatase, a key regulator of sphingolipid metabolism and stress response. Proc. Nat. Acad. Sci. USA 95: 150-155.
29. Mattie, M., Brooker, G., and Spiegel, S. (1994) Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J. Biol. Chem. 269: 3181-3188.
30. Desai, N. N., Zhang, H., Olivera, A., Seki, T., Brooker, G., and Spiegel, S. (1992) Sphingosine-1-phosphate, a metabolite of Sphingosine, increases phosphatidic acid levels by phospholipase D activation. J. Biol. Chem. 267: 23122-23128.
31. Wu, J., Spiegel, S., and Sturgill, T. W. (1995) Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. J. Biol. Chem. 270: 11484-11488.
32. Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P. G., Coso, O. A., Gutkind, S., and Spiegel, S. (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381: 800-803.
33. Wang, F., Buckley, N. E., Olivera, A., Goodemote, K. A., Su, Y., and Spiegel, S. (1996) Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1. Glycoconjugate J. 13: 937-45.
34. Mazurek, N., Megidish, T., Hakomori, S.-I., and Igarashi, Y. (1994) Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response. Biochem. Biophys. Res. Commun. 198: 1-9.
35. Edsall, L. C., Pirianov, G. G., and Spiegel, S. (1997) Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J. Neurosci. 17: 6952-6960.
36. Stoffel, W., Hellenbroich, B., and Heimann, G. (1973) Properties and specificities of sphingosine kinase from blood platelets. Hoppe-Seyler's Z. Physiol. Chem. 354: 1311-1316.
37. Ghosh, T. K., Bian, J., and Gill, D. L. (1994) Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J. Biol. Chem. 269: 22628-22635.
38. Choi, O., H., Kim, J.-H., and Kinet, J.-P. (1996) Calcium mobilization via sphingosine kinase in signalling by the FceRI antigen receptor. Nature 380: 634-636.
39. Fatatis, A., and Miller, R. J. (1997) Platelet-derived growth factor (PDGF)-induced Ca2+ signaling in the CG4 oligodendroglial cell line and in transformed oligodendrocytes expressing the β-PDGF receptor. J. Biol. Chem. 272: 4351-4358.
40. Fatatis, A., and Miller, R. J. (1996) Sphingosine and sphingosine 1-phosphate differentailly modulate platelet-derived growth factor-BB-induced Ca2+ signaling in transformed oligodendrocytes. J. Biol. Chem. 271: 295-301.
41. Spiegel, S., and Milstien, S. (1996) Sphingoid bases and phospholipase D activation. Chem. Physics Lipids 80: 27-36.
42. Venable, M. E., Blobe, G. C., and Obeid, L. M. (1994) Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. J. Biol. Chem. 269: 26040-26044.
43. Gomez-Munoz, A., Martin, A., O'Brien, L., and Brindley, D. N. (1994) Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J. Biol. Chem. 269: 8937-8943.
44. Goodemote, K. A., Mattie, M. E., Berger, A., and Spiegel, S. (1995) Involvement of a pertussis toxin sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate. J. Biol. Chem. 270: 10272-10277.
45. Okajima, F., Tomura, H., Sho, K., Kimura, T., Sato, K., Im, D. S., Akbar, M., and Kondo, Y. (1997) Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. Endocrinology 138: 220-9.
46. Törnquist, K. (1997) Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. Am. J. Physiol. 272: C1052-7.
47. Rani, C. S., Berger, A., Wu, J., Sturgill, T. W., Beitner-Johnson, D., LeRoith, D., Varticovski, L., and Spiegel, S. (1997) Divergence in signal transduction pathways of PDGF and EGF receptors: Involvement of sphingosine-1-phosphate in PDGF but not EGF signaling. J. Biol. Chem. 272: 10777-10783.
48. Wang, F., Nobes, C. D., Hall, A., and Spiegel, S. (1997) Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Biochem. J. 324: 481-488.
49. Blakesly, V. A., Beitner-Johnson, D., Van Brocklyn, J. R., Rani, S., Shen-Orr, Z., Stannard, B. S., Spiegel, S., and LeRoith, D. (1997) Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. J. Biol. Chem. 272: 16211-16215.
50. Obeid, L. M., Lindaric, C. M., Karolak, L. A., and Hannun, Y. A. (1993) Programmed cell death induced by ceramide. Science 259: 1769-1771.
51. Jarvis, W. D., Fornari, F. A., Jr., Browning, J. L., Gewirtz, D. A., Kolesnick, R. N., and Grant, S. (1994) Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J. Biol. Chem. 269: 31685-31692.
52. Tepper, C. G., Jayadev, S., Liu, B., Bielawska, A., Wolff, R., Yonehara, S., Hannun, Y. A., and Seldin, M. F. (1995) Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl. Acad. Sci. U.S.A. 92: 8443-8447.
53. Nikolova-Karakashian, M., Morgan, E. T., Alexander, C., Liotta, D. C., and Merrill, A. H., Jr. (1997) Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11. J. Biol. Chem. 272: 18718-18724.
54. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
55. Chen, Y.-R., Meyer, C. F., and Tan, T.-Y. (1996) Persistent activation of c-jun N-terminal kinase 1 (JNK1) in g radiation-induced apoptosis. J. Biol. Chem. 271: 631-634.
56. Marshall, C. J. (1995) Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185.
57. Nicholson, D. W., and Thornberry, N. A. (1997) Caspases: killer proteases. 22: 299-306.
58. Smyth, M. J., Perry, D. K., Zhang, J., Poirier, G. G., Hannun, Y. A., and Obeid, L. M. (1996) prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J. 316: 25-28.
59. Dbaibo, G. S., Perry, D. K., Gamard, C. J., Platt, R., Poirier, G. G., Obeid, L. M., and Hannun, Y. A. (1997) Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-a: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185: 481-490.
60. Cuvillier, O., Rosenthal, D. S., Smulson, M. E., and Spiegel, S. (1998) Sphingosine-1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas-and ceramide-mediated apoptosis in Jurkat T lymphocytes. 273: 2910-2916.
61. Nickels, J. T., and Broach, J. R. (1996) A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Sacharromyces cerevisiae. Genes Dev. 10: 382-394.