Role of 5-HT2A and 5-HT2B/2C receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors

Neuropsychopharmacology

Volumn 24, Issue 3, 2001, Pages 319-329

  McMahon, Lance R ^a   Cunningham, Kathryn A ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

5 HT2A Receptors; 5 HT2C Receptors; Dopamine; Locomotor activity; Serotonin

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; FLUVOXAMINE; MAZINDOL; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BIOGENIC MONOAMINES; CATECHOLAMINES; DEPRESSION; DOPAMINE; DRUG SYNERGISM; FLUOROBENZENES; FLUVOXAMINE; INDOLES; MALE; MAZINDOL; MOTOR ACTIVITY; PIPERIDINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SCHIZOPHRENIA; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SUBSTANCE-RELATED DISORDERS;

EID: 0035130648     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(00)00206-2     Document Type: Article

References (64)

1. 2C receptor protein in human and rat brain using specific antisera
2. Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: Effect on dopaminergic and serotonergic functions
3. A review of central 5-HT receptors and their function
4. Serotonin-facilitated dopamine release in vivo: Pharmacological characterization
5. 2A receptor antagonist MDL 100907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic, or muscarinic neurotransmission in the mouse - Implications for psychosis
6. (1C) receptors
7. 2C receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation
8. Discriminative stimulus properties of the novel serotonin (5-HT) 5-HT2C receptor agonist, RO 60-0175: A pharmacological analysis
9. Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: A combined in vivo electrophysiological and microdialysis study
10. 2B/2C receptors enhances dopamine release in the rat nucleus accumbens
11. Biotransformation of mazindol. III. Comparison of metabolism in rat, dog, and man
12. Characterization of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum
13. Involvement of dopamine receptors on locomotor stimulation and sensitization elicited by the interaction of ethanol and mazindol in mice
14. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways
15. 2c receptors in mice
16. 2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely moving rats
17. Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan
18. Fluoxetine increases the extracellular levels of serotonin in the nucleus accumbens
19. 3H-biogenic amines in rat brain tissue slices
20. 3H-norepinephrine in slices of rat neostriatum and cerebral cortex
21. 2C receptor mutant mice
22. Involvement of serotonin in the modulation of cocaine-induced locomotor activity in the rat
23. Serotonin axon terminals in the ventral tegmental area of the rat: Fine structure and synaptic input to dopaminergic neurons
24. Pharmacokinetics of selective reuptake inhibitors
25. Citalopram: Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
26. Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
27. Serotonin-mediated increase in prefrontal cortex dopamine release: Pharmacological characterization
28. In vivo biogenic amine efflux in medial prefrontal cortex with imipramine, fluoxetine, and fluvoxamine
29. Serotonin, dopamine and their interactions in schizophrenia
30. 2A antagonist with a favorable CNS safety profile
31. 2A antagonist M100907 on MDMA-induced locomotor stimulation in rats
32. Serotonin afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons
33. 2B receptor antagonist with anxiolytic-like properties
34. Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain
35. Depression and stimulant dependence: Neurobiology and pharmacotherapy
36. Mazindol anorexia is mediated by activation of dopaminergic systems
37. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers
38. 3H]M100907
39. 2C receptor subtypes in the control of in vivo dopamine outflow in the rat striatum
40. Reserpine-induced locomotor stimulation in mice chronically treated with typical and atypical antidepressants
41. Repeated treatment with antidepressant drugs potentiates the locomotor response to (+)-amphetamine
42. Functional regulation by dopamine receptors of serotonin release from the rat hippocampus: In vivo microdialysis study
43. 2C/2B antagonist SB 206553 on hyperactivity induced by cocaine
44. Potentiation of cocaine-induced hyperactivity by infusion of selective serotonin reuptake inhibitors into the rat nucleus accumbens shell
45. 2A receptors attenuates the behavioral effects of cocaine in rats
46. 2A antagonist
47. Anomalous effect of mazindol on dopamine uptake as measured by in vivo voltametry and microdialysis
48. Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis
49. 2C receptors
50. Serotonin-dopamine interaction in the rat ventral tegmental area: An electrophysiological study in vivo
51. Sertraline and cocaine-induced locomotion in mice
52. The central stimulatory action of inhibitors of the dopamine uptake
53. Functional interaction between serotonin and other neuronal systems: Focus on in vivo microdialysis studies
54. Cocaine: Discussion on the role of dopamine in the biochemical mechanism of action
55. 2 receptors exert a state-dependent regulation of dopaminergic function: Studies with MDL 100907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine
56. Acute fluoxetine treatment potentiates amphetamine-hyperactivity and amphetamine-induced accumbens-dopamine release: Possible pharmacokinetic interaction
57. The potentiating effect of sertraline and fluoxetine on amphetamine-induced locomotor activity is not mediated by serotonin
58. 2 receptor antagonist M100907 as a putative atypical antipsychotic: Behavioral, electrophysiological, and neurochemical studies
59. The nucleus raphe dorsalis of the rat and its projection upon the caudate-putamen. A combined cytoarchitectonic, immunocytochemical, and retrograde transport study
60. Some effects of mazindol, an anorectic drug, on rat brain monoaminergic systems
61. Dorsal raphe cells with collateral projections to the caudate-putamen and substantia niga: A fluorescent retrograde double labeling study in the rat
62. 3H]dopamine by serotonin from superfused rat striatal slices
63. Fluoxetine and two other serotonin uptake inhibitors without affinity for neuronal receptors