Carrier-dependent and Ca2+-dependent 5-HT and dopamine release induced by(+)-amphetamine, 3,4,-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine

British Journal of Pharmacology

Volumn 121, Issue 8, 1997, Pages 1735-1743

  Crespi, Daniela ^a   Mennini, Tiziana ^a   Gobbi, Marco ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

(+) amphetamine; (+) fenfluramine; 3,4 methylendioxymethamphetamine; 5 hydroxytryptamine release; 5 hydroxytryptamine transporters; Carrier mediated release; Dopamine release; Dopamine transporters; Exocytotic release; P chloroamphetamine

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; CALCIUM CHANNEL; CALCIUM ION; CHLORAMPHETAMINE; DOPAMINE; FENFLURAMINE; INDALPINE; METITEPINE; NEUROTRANSMITTER; NOMIFENSINE; OMEGA AGATOXIN IVA; SEROTONIN;

ANIMAL TISSUE; ARTICLE; BRAIN; CALCIUM TRANSPORT; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG POTENCY; EXTRACELLULAR CALCIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SYNAPTOSOME;

AMPHETAMINE; ANIMALS; CALCIUM; CARRIER PROTEINS; DOPAMINE; FENFLURAMINE; MALE; METHIOTHEPIN; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTRANSMITTER UPTAKE INHIBITORS; P-CHLOROAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 0030796047     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701325     Document Type: Article

References (53)

1. BAUMGARTEN, H.G. & ZIMMERMANN, B. (1992). Neurotoxic phenylalkylamines and indolealkylamines. In Selective Neurotoxicity. ed. Herken, H. & Hucho, F. pp. 225-291. Berlin: Springer-Verlag.
2. BERGER, U.V., GU, X.F. & AZMITIA, E.C. (1992). The substituted amphetamines 3,4-methylendioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induced 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. Eur. J. Pharmacol., 215, 153-158.
3. BONANNO, G., FASSIO, A., SEVERI, P., RUELLE, A. & RAITERI, M. (1994). Fenfluramine releases serotonin from human brain nerve endings by a dual mechanism. J. Neurochem., 63, 1163-1166.
4. BONISH, H. (1984). The transport of (+)-amphetamine by the neuronal noradrenaline carrier. Naunyn-Schmiedeberg's Arch. Pharmacol., 327, 267-272.
5. 3H]GBR 12783 binding to a specific site associated with the neuronal dopamine uptake complex in the central nervous system. Eur. J. Pharmacol., 126, 211-222.
6. BOWYER, J.F., SPUHLER, K.P. & WEINER, N. (1984). Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes. J. Pharmacol. Exp. Ther., 229, 671-680.
7. CINQUANTA, M., RATOVITSKI, T., GOBBI, M., MENNINI, T. & SIMANTOV, R. (1997). Carrier-mediated serotonin release induced by d-fenfluramine: studies with human neuroblastoma cells transfected with a rat serotonin transporter. Neuropharmacology, 36, 803-809.
8. DELEAN, A., MUNSON, P.J. & RODBARD, D. (1978). Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol., 235, E97-E102.
9. ESHLEMAN, A.J., HENNINGSEN, R.A., NEVE, K.A. & JANOWSKY, A. (1994). Release of dopamine via the human transporter. Mol. Pharmacol., 45, 312-316.
10. FISHER, J.F. & CHO, A.K. (1979). Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model. J. Pharmacol. Exp. Ther., 208, 203-209.
11. 3H]-5-HT release from rat hippocampal synaptosomes. Neuropharmacology, 33, 833-835.
12. GALLI, A., BLAKELY, R.D. & DEFELICE, L.J. (1996). Norepinephrine transporters have channel modes of conduction. Proc. Natl. Acad. Sci. U.S.A., 93, 8671-8676.
13. GARATTINI, S., BIZZI, A., CACCIA, S. & MENNINI, T. (1992). Progress report on the anorectic affects of dexfenfluramine. fluoxetine and sertraline. Int. J. Obes., 16, (Suppl. 3), S43-S50.
14. GARDIER, A.M., KAAKKOLA, S., ERFURTH, A. & WURTMAN, R.J. (1992). Effects of methiothepin on changes in brain serotonin release induced by repeated administration of high doses of anorectic serotoninergic drugs. Brain Res., 588, 67-74.
15. 3H]serotonin. Naunyn-Schmiedeberg's Arch. Pharmacol., 345, 1-6.
16. 3H]-5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes. Eur. J. Pharmacol., 238, 9-17.
17. GOLDSTEIN, D.S., FEUERSTEIN, G. IZZO, J.L., KOPIN, I.J. & KEISER, H.R. (1981). Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man. Life Sci., 28, 467-475.
18. GRAY, E.G. & WHITTAKER, V.P. (1962). The isolation of nerve endings from brain: An electron-microscope study of cell fragments derived by homogenization and centrifugation. J. Anat., 96, 79-87.
19. GREEN, A.R., CROSS, A.J. & GOODWIN, G.M. (1995). Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy'). Psychopharmacology, 119, 247-260.
20. HEKMATPANAH, C.R. & PEROUTKA, S.J. (1990). 5-Hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylene-dioxymethamphetamine and related agents. Eur. J. Pharmacol., 177, 95-98.
21. HOYER, D. (1988). Functional correlates of serotonin 5-HT1 recognition sites. J. Receptor Res., 8, 59-81.
22. 3H]dopamine release from superfused rat brain slices. Eur. J. Pharmacol., 132, 269-276.
23. LEVI, G. & RAITERI, M. (1974). Exchange of neurotransmitter amino acid at nerve endings can simulate high affinity uptake. Nature, 250, 735-373.
24. LEVI, G & RAITERI, M. (1993). Carrier-mediated release of neurotransmitters. Trends Neurosci., 16, 415-419.
25. 3H]dopamine from isolated corpus striatum by amphetamine, fenfluramine and unlabelled dopamine. Biochem. Pharmacol., 31, 983-992.
26. MAGER, S., MIN, C., HENRY, D.J. CHAVKIN, C., HOFFMAN, B.J., DAVIDSON, N. & LESTER, H.A. (1995). Conducting states of a mammalian serotonin transporter. Neuron, 12, 845-859.
27. MAURA, G., GEMIGNANI, A., VERSACE, P., MARTIRE, M. & RAITERI, M. (1982). Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings. Neurochem. Int., 4, 219-224.
28. 3H-5-hydroxytryptamine. Pharmacol. Biochem. Behav., 38, 505-512.
29. MENNINI, T., BIZZI, A., CACCIA, S., CODEGONI, A., FRACASSO, C., FRITTOLI, E., GUISO, G., MARTIN PADURA, I., TADDEI, C., USLENGHI, A. & GARATTINI, S. (1991). Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs. Naunyn-Schmiedeberg's Arch. Pharmacol., 343, 483-490.
30. MENNINI, T., BORRONI, E., SAMANIN, R. & GARATTINI, S. (1981) Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin. Neurochem. Int., 3, 289-294.
31. MENNINI, T., GOBBI, M., CRESPI, D., CINQUANTA, M., FRITTOLI, E., GIORCELLI, P., ANELLI, M. & CACCIA, S. (1996). In vivo and in vitro interaction of flunarizine with D-fenfluramine serotonergic effects. Pharmacol. Biochem. Behav., 53, 155-161.
32. MINTZ, I.M., VENEMA, V.J., SWIDEREK, K.M., LEE, T.D., BEAN, B.P. & ADAMS, M.E. (1992). P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature, 355, 827-829.
33. PIFL, C., DROBNY, H., REITHER, H., HORNYKIEWICZ, O. & SINGER, E.A. (1995). Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Mol. Pharmacol., 47, 368-373.
34. PREMKUMAR, L.S. & AHERN, G.P. (1995). Blockade of a resting potassium channels and modulation of synaptic transmission by ecstasy in the hippocampus. J. Pharmacol. Exp. Ther., 274, 718-722.
35. RAITERI, M., ANGELINI, F. & LEVI, G. (1974). A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur. J. Pharmacol., 25, 411-414.
36. RAITERI, M., CERRITO, F., CERVONI, A.M. & LEVI, G. (1979). Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine. J. Pharmacol. Exp. Ther., 208, 195-202.
37. RAITERI, M., FEDERICO, R., COLETTI, A. & LEVI, G. (1975). Release and exchange studies relating to the synaptosomal uptake of GABA. J. Neurochem., 24, 1243-1250.
38. RUDNICK, G. & WALL, S.C. (1992a). p-Chloroamphetamine induces serotonin release through serotonin transporters. Biochemistry, 31, 6710.
39. RUDNICK, G. & WALL, S.C. (1992b). The molecular mechanism of 'ecstasy' [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl. Acad. Sci. U.S.A., 89, 1817-1821.
40. SCHULDINER, S., STEINER-MURDOCH, S., YELIN, R., WALL, S.C. & RUDNICK, G. (1993). Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Mol. Pharmacol., 44, 1227-1231.
41. SEIDEN, L.S., SABOL, K.E. & RICAURTE, G.A. (1993). Amphetamine: effects on catecholamine systems and behaviour. Annu. Rev. Pharmacol. Toxicol., 32, 639-677.
42. SONDERS, M.S. & AMARA, S.G. (1996). Channels in transporters. Curr. Opinion Neurobiol., 6, 294-302.
43. SULZER, D., CHEN, T.-K., LAU, Y.Y., KRISTENSEN, H., RAYPORT, S. & EWING, A. (1995). Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J. Neurosci., 15, 4102-4108.
44. SULZER, D. & RAYPORT, S. (1990). Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action. Neuron, 5, 797-808.
45. 3H]dopamine depletion from osmotically defined storage sites: effects of reserpine, 53 mM KCl, and d-amphetamine. J. Neurochem., 41, 119-127.
46. TRENDELEMBURG, U. (1979). Release induced by phenethylamines. In The Release of Catecholamines from Adrenergic Neurons. ed. Paton, D.M. pp. 333-354. Oxford: Pergamon Press.
47. 3H]dopamine uptake in rat striatum: possible involvement of calmodulin-dependent kinases. J. Neurochem., 65, 2065-2071.
48. WALL, S.C., GU, H. & RUDNICK, G. (1995). Biogenic amine flux mediated by cloned transporters stably expressed in cultures cell lines: amphetamine specificity for inhibition and efflux. Mol. Pharmacol., 47, 544-550.
49. WHITE, T.D. (1975). A role for divalent cations in the uptake of noradrenaline by synaptosomes. J. Neurochem., 24, 1037-1042.
50. WICKEMS, C.H., HOLLINGSWORTH, C.K. & BENNETT, B.A. (1995). Release of serotonin induced by 3,4-methylendioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release. Brain Res., 695, 10-18.
51. WÖLFEL, R. & GRAEFE, K.-H. (1992). Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. Naunyn-Schmiedeberg's Arch. Pharmacol., 345, 129-136.
52. 3H]5-hydroxytryptamine uptake in rat cortex. Brain Res., 738, 96-102.
53. 3H]amphetamine with rat brain synaptosomes. II. Active transport. J. Pharmacol. Exp. Ther., 257, 830-835.