Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

Human Gene Therapy

Volumn 13, Issue 1, 2002, Pages 143-154

  Morral, Núria ^a   O’Neal, Wanda K ^a   Rice, Karen ^b   Leland, M Michelle ^b   Piedra, Pedro A ^a   Aguilar CɃrdova, Estuardo ^a   Carey, K Dee ^b   Beaudet, Arthur L ^a   Langston, Claire ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Department of Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; LIVER ENZYME; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BABOON; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM INJURY; GENE EXPRESSION; HISTOPATHOLOGY; LETHAL DOSE; LETHALITY; LIVER; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIMATE; SPLEEN; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TISSUE DISTRIBUTION; TRANSGENE; VASCULAR ENDOTHELIUM;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; ENDOTHELIUM, VASCULAR; GENETIC VECTORS; INFUSIONS, INTRAVENOUS; INTERLEUKIN-6; INTERLEUKIN-8; LIVER; MALE; MICE; MICE, INBRED C57BL; PAPIO; PLATELET COUNT; THROMBOCYTOPENIA; TISSUE DISTRIBUTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; PAPIO; PAPIO HAMADRYAS; PRIMATES;

EID: 0036145244     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340152712692     Document Type: Article

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