CD40-CD40L interactions in atherosclerosis

Trends in Cardiovascular Medicine

Volumn 12, Issue 1, 2002, Pages 27-32

  Lutgens, Esther ^a   Daemen, Mat J A P ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND;

ANTIGEN EXPRESSION; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; FIBROBLAST; HUMAN; HYPERLIPIDEMIA; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD40; ARTERIOSCLEROSIS; CD40 LIGAND; FORECASTING; HUMANS; ORGAN TRANSPLANTATION;

EID: 0036140664     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(01)00142-6     Document Type: Review

References (63)

1. Blockade of CD40-CD40 ligand interactions protects against radiation induced pulmonary inflammation and fibrosis
2. Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice
3. CD40 expression by human monocytes; regulation by cytokines and activation of monocytes by the ligand for CD40
4. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
5. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T-lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes
6. A Leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice
7. Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions
8. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
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11. Phase I clinical trial of a monoclonal antibody against CD40L in patients with systemic lupus erythematosus
12. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice
13. CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells
14. Immunologic reconstitution following bone marrow transplantation in the X-linked hyper IgM syndrome
15. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40
16. T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis
17. Immune regulation by CD40 and its ligand GP39
18. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis
19. A central role of CD40 ligand in the regulation of CD4+ T-cell responses
20. Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions
21. T-lymphocytes inhibit vascular response to injury
22. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
23. Pro-inflammatory cytokines and CD40 ligand enhance cross cross-priming capability of human dendritic cells internalizing cancer cells
24. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
25. CD40 on human endothelial cells; inducibility by cytokines and functional regulation of adhesion molecule expression
26. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
27. CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive β-chemokines
28. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
29. Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice
30. Molecular bases of the acute coronary syndromes
31. Regulation of the thrombotic potential of atheroma
32. Inflammation and thrombosis. The clot thickens
33. Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival
34. Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype
35. Requirement for CD154 in the progression of atherosclerosis
36. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40. Induction of collagenase, stromelysin, and tissue factor
37. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages; implications for CD40-CD40 ligand signaling in atherosclerosis
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40. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice
41. Atherosclerosis; the emerging role of inflammation and the CD40-CD40 ligand system
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43. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice
44. Absence of CD40 signaling is associated with an increase in intimal thickening after arterial injury
45. Humoral immune response in CD40 ligand-deficient mice
46. CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection
47. Atherosclerosis. An inflammatory disease
48. Ligation of CD40 activtes interleukin 1β-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1β
49. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T-lymphocytes. A role for CD40 signaling in plaque rupture?
50. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells
51. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
52. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis
53. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation
54. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
55. Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antobody
56. CD40 ligation for immunotherapy of solid tumours
57. Anti-CD40 antibody induces antitumour and anti-metastatic effects; the role of NK cells
58. CD40-CD40 ligand; a multifunctional receptor-ligand pair
59. Transforming growth factor beta; the good, the bad and the ugly
60. Mice deficient for the CD40 ligand
61. Functional interactions of T cells with endothelial cells; the role of CD40L-CD40-mediated signals
62. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) upregulation and Il-6 production and proliferation
63. CD40/CD40 ligand interactions are critical for elicitation of auto-immune-mediated fibrosis in the lung