CD40 ligation for immunotherapy of solid tumours

Journal of Immunological Methods

Volumn 248, Issue 1-2, 2001, Pages 139-147

  Todryk, Stephen M ^a,c   Tutt, Alison L ^b   Green, Michael H A ^b   Smallwood, J A ^b   Halanek, Nicole ^a   Dalgleish, Angus G ^a   Glennie, Martin J ^b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

CD40 ligation; Monoclonal antibody; T cell response; Tumour immunotherapy

Indexed keywords

ANTIBODY; ANTIBODY CD 40; ANTIBODY CD 80; CYTOKINE; HELPER FACTOR; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOGENICITY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SOLID TUMOR; T LYMPHOCYTE ACTIVATION; TUMOR RESISTANCE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD40; COLORECTAL NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED STRAINS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

MUS MUSCULUS;

EID: 0035251797     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(00)00349-5     Document Type: Article

References (23)

1. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
2. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
3. Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T-cells
4. Tumour cell expression of B7 costimulatory molecules and interleukin-12 or granulocyte-macrophage colony-stimulating factor induces a local antitumour response and may generate systemic protective immunity
5. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
6. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth
7. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
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9. Anti-tumour activity against B16-F10 melanoma with a GM-CSF secreting allogeneic tumour cell vaccine
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11. Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T-cells
12. Tumor antigens are constitutively presented in the draining lymph nodes
13. CD40 activation boosts T-cell immunity in vivo by enhancing T-cell clonal expansion and delaying peripheral T-cell deletion
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