Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions

American Journal of Cardiology

Volumn 87, Issue 1, 2001, Pages 21-27

  Bruemmer, Dennis ^a   Riggers, Urte ^a   Holzmeister, Johannes ^a   Grill, Matthias ^a   Lippek, Frank ^a   Settmacher, Utz ^a   Regitz Zagrosek, Vera ^a   Fleck, Eckart ^a   Graf, Kristof ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; MONOCLONAL ANTIBODY;

ANTIGEN EXPRESSION; ARTERY DIAMETER; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; ILIAC ARTERY; IMMUNOHISTOLOGY; INFLAMMATION; INTIMA; LYMPHOCYTE; MACROPHAGE; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WORLD HEALTH ORGANIZATION;

AGED; ANTIGENS, CD40; ARTERIOSCLEROSIS; CD40 LIGAND; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; ILIAC ARTERY; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; SIGNAL TRANSDUCTION;

EID: 0035190623     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(00)01266-2     Document Type: Article

References (22)

1. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis
2. Stimulation of CD40 with purified gp39 induces proinflammatory responses in human monocytes
3. Ligation of CD40 activates interleukin 1β-converting enzyme activity in vascular smooth muscle cells and endothelial cells and promotes elaboration of active interleukin 1β
4. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: A role for CD40 signaling in plaque rupture?
5. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: Induction of collagenase, stromelysin, and tissue factor
6. T-lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanismn: Implications for tubule formation
7. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation
8. CD40 on human endothelial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression
9. Expression of functional CD40 by vascular endothelial cells
10. Leucocyte recruitment in rupture prone regions of lipid-rich plaques: A prominent role for neovascularization?
11. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes
12. CD40L activation in circulating platelets in patients with acute coronary syndrome
13. Reduction of atherosclerosis in mice by inhibition of CD40 signalling
14. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
15. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
16. The classification of atheroclerotic lesions. Report of a study group
17. Techniques for the study of of normal and atherosclerotic arterial intima from its endothelial surface
18. CD40-CD40L interactions in atherosclerosis
19. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
20. Functional interactions of T cells with endothelial cells: The role of CD40L-CD40-mediated signals
21. Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappaB and signal transducer and activation of transcription-1
22. Expression of stromelysin-3 in atherosclerotic lesions: Regulation via CD40-CD40 ligand signaling in vitro and in vivo