Inhibition of HERG potassium channels by cocaethylene: A metabolite of cocaine and ethanol

Cardiovascular Research

Volumn 53, Issue 1, 2002, Pages 59-67

  O'Leary, Michael E ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Ion channels; K channel; Long QT syndrome; Membrane currents

Indexed keywords

ALCOHOL; COMPLEMENTARY DNA; HOMOCOCAINE; POTASSIUM CHANNEL;

ARTICLE; CELL LINE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LONG QT SYNDROME; PATCH CLAMP; PRIORITY JOURNAL;

CELL LINE; COCAINE; ETHANOL; GENE EXPRESSION; HUMANS; ION CHANNEL GATING; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; TRANSFECTION;

EID: 0036135799     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00458-8     Document Type: Article

References (33)

1. Cardiovascular complications of cocaine
2. Cocaine: A review of its toxic actions on cardiac function
3. Cardiovascular and subjective effects of intravenous cocaine administration in humans
4. Cocaine plasma concentration: Relation to physiological and subjective effects in humans
5. Ethanol and cocaine interactions in humans: Cardiovascular consequences
6. Cocaine, ethanol, and cocaethylene cardiotoxicity in an animal model of cocaine and ethanol abuse
7. Cocaine and cocaethylene concentrations in human postmortem cerebral cortex
8. Concurrent and simultaneous use of alcohol with cocaine: Results of national survey
9. Alcohol and cocaine interactions in humans
10. Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine
11. Cocaethylene causes dose-dependent reductions in cardiac function in anesthetized dogs
12. Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats
13. Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels
14. + current. Differential sensitivity to block by class III antiarrhythmic agents
15. Kr potassium channel
16. High affinity open channel block by dofetilide of HERG expressed in a human cell line
17. Mechanisms and management of proarrhythmia
18. Characterization of the isoform-specific differences in the gating of neuronal and muscle sodium channels
19. + current in cardiac myocytes by dofetilide
20. + current in rabbit ventricular myocytes
21. Inhibition of human ether-a-go-go potassium channels by cocaine
22. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
23. Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter
24. Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion
25. Interaction of tetraethylammonium ion derivatives with the potassium channel of giant axon
26. + channel. Open-channel block by methanesulfonanilides
27. + channels
28. Cocaine blocks HERG, but not KvLQT1+minK, potassium channels
29. Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites
30. A structural basis for drug-induced long QT syndrome
31. Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit
32. Comprehensive review of cocaethylene and cocaine concentrations in patients