Inhibition of human ether-a-go-go potassium channels by cocaine

Molecular Pharmacology

Volumn 59, Issue 2, 2001, Pages 269-277

  O'Leary, Michael E ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; MEMBRANE PROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; PROTEIN HERG; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; COCAINE DEPENDENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG MECHANISM; DRUG POTENCY; HEART REPOLARIZATION; HEART STIMULATION; HUMAN; HUMAN CELL; PATCH CLAMP; POTASSIUM TRANSPORT; PRIORITY JOURNAL;

EID: 0035133687     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.2.269     Document Type: Article

References (43)

1. Cocaine-related sudden cardiac death: A hypothesis correlating basic science and clinical observations
2. Hemodynamic and electrophysiological actions of cocaine. Effects of sodium bicarbonate as an antidote in dogs
3. Mechanisms responsible for the cardiotoxic effects of cocaine
4. Cocaine: A review of its toxic actions on cardiac function
5. Blockade of HERG channels by the class III antiarrhythmic azimilide: Mode of action
6. Analysis of the ionic basis for cocaine's biphasic effect on action potential duration in guinea-pig ventricular myocytes
7. Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes
8. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
9. Quantitative analysis of amounts of coronary arterial narrowing in cocaine addicts
10. Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats
11. + channels
12. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
13. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
14. Cardiovascular complications of cocaine
15. + current by dofetilide
16. Molecular physiology and pharmacology of HERG: Single-channel currents and block by dofetilide
17. Early afterdepolarizations and triggered activity induced by cocaine. A possible mechanism of cocaine arrhythmogenesis
18. The effects of acute and chronic cocaine use on the heart
19. Trapping of a methanesulfonanilide by closure of the herg potassium channel activation gate
20. Death caused by recreational cocaine use. An update
21. + channels. Cocaine vs quaternary compounds
22. Characterization of the isoform-specific differences in the gating of neuronal and muscle sodium channels
23. Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines
24. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions
25. Kr potassium channel
26. Cocaine and cardiovascular toxicity
27. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
28. The inward rectification mechanism of the HERG cardiac potassium channel
29. High affinity open channel block by dofetilide of HERG expressed in a human cell line
30. + channel. Open-channel block by methanesulfonanilides
31. Fast inactivation causes rectification of the IKr channel
32. The inhibition of sodium channels in myelinated nerve by quaternary derivatives of lidocaine
33. Specific block of cloned HERG channels by clofilium and its tertiary analog LY97241
34. Cocaine and the heart
35. The effects of cocaine on cardiac electrophysiology in conscious, unsedated dogs
36. HERG, a human inward rectifier in the voltage-gated potassium channel family
37. Cardiovascular effects of cocaine: An autopsy study of 40 patients
38. Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes
39. 0 and C-type inactivation
40. Kr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects
41. Mechanism of cocaine block of HERG potassium channels
42. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
43. + channels expressed in Xenopus oocytes