Comprehensive review of cocaethylene and cocaine concentrations in patients

American Journal of Clinical Pathology

Volumn 106, Issue 6, 1996, Pages 701-704

  Bailey, David N ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

Cocaethylene; Cocaine; Concentrations; Correlation; Ethanol; Plasma; Ratio; Urine

Indexed keywords

COCAINE; HOMOCOCAINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CORRELATION FUNCTION; DRUG BLOOD LEVEL; DRUG DEPENDENCE; DRUG URINE LEVEL; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0030465391     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/106.6.701     Document Type: Article

References (13)

1. Jatlow P, Elsworth JD, Bradberry CW, et al. Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion. Life Sci 1991;48:1787-1794.
2. Hearn WL, Flynn DD, Hime GW, et al. Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem 1991;56:698-701.
3. Hearn WL, Rose S, Wagner J, Ciarleglio A, Mash DC. Cocaethylene is more potent than cocaine in mediating lethality. Pharmacol Biochem Behav 1991;39:531-533.
4. Schuelke GS, Terry LC, Powers RH, Rice J, Madden JA. Cocaine analgesia: An in vivo structure-activity study. Pharmacol Biochem Behav 1996;53:133-139.
5. Bailey DN. Serial plasma concentrations of cocaethylene, cocaine, and ethanol in trauma victims. J Anal Toxicol 1993;17:79-83.
6. Dean RA, Christian CD, Sample RHB, Bosron WF. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J 1991;5:2735-2739.
7. Brzezinski MR, Abraham TL, Stone CL, Dean RA, Bosron WF. Purification and characterization of a human liver cocaine carbox ylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem Pharmacol 1994;48:1747-1755.
8. Bailey DN. Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit. Am J Clin Pathol 1993;99:123-127.
9. Bailey DN. Thin-layer Chromatographic detection of cocaethylene in human urine. Am J Clin Pathol 1994;101:342-345.
10. Bailey DN, Bessler JB, Sawrey BA. Cocaine and cocaethylene:creatinine clearance ratios in man. J Anal Toxicol 1996 (in press).
11. Jatlow P, Nadim H. Determination of cocaine concentrations in plasma by high-performance liquid chromatography. Clin Chem 1990;36:1436-1439.
12. Jatlow PI, Bailey DN. Analytical toxicology. In: Sonnenwirth A, Jarett L, eds. Gradwohl's Clinical Laboratory Methods and Diagnosis. St. Louis: CV Mosby, 1980, pp 387-434.
13. Bailey DN, Guba JJ. Survey of emergency toxicology screening in a university medical center. J Anal Toxicol 1979;3:133-136.