Ly-6a.2 expression regulates antigen-specific CD4+ T cell proliferation and cytokine production

Journal of Immunology

Volumn 168, Issue 1, 2002, Pages 118-126

  Henderson, S C ^a   Kamdar, M M ^a   Bamezai, A ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CELL PROTEIN; INTERLEUKIN 4; LY 6A.2 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CELL ADHESION; CONTROLLED STUDY; CYTOKINE PRODUCTION; LIGAND BINDING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENE;

EID: 0036134851     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.1.118     Document Type: Article

References (77)

1. CTLA-4 can function as a negative regulator of T cell activation
2. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide Proc
3. Mature T lymphocyte apoptosis: Immune regulation in a dynamic and unpredictable antigenic environment
4. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
5. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
6. Interleukin-2 receptor a chain regulates the size and content of the peripheral lymphoid compartment
7. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
8. 2-dependent ubiquitin-protein ligase
9. HPK1 is activated by lymphocyte antigen receptors and negatively regulates API
10. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling
11. Negative regulation of T cell activation
12. The molecular basis of T helper 1 and T helper 2 cell differentiation
13. Signaling and transcription in T helper development
14. Immunologic basis of antigen-induced airway hyperresponsiveness
15. Redirecting Th2 responses in allergy
16. + effector T cells and susceptibility to infectious diseases
17. Crossregulation between Th1 and Th2 cells
18. The Ly-6 locus: A multigene family encoding phosphatidyl-inositol-anchored membrane proteins concerned with T cell activation
19. Tissue expression, structure and function of the murine Ly-6 family of molecules
20. Studies of the mouse Ly-6 alloantigen system. II. Complexities of the Ly-6 region
21. Cell surface structures involved in T cell activation
22. + cells of an antigen not associated with the TCR complex but involved in T cell activation
23. Distribution of Ly-6C on lymphocyte subsets: I. Influence of allotype on T lymphocyte expression
24. Isolation of a cDNA encoding thymic shared antigen-1: A new member of the Ly-6 family with a possible role in T cell development
25. Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern of expression
26. Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-γ
27. Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins
28. Interrelationships of the "Ly-6 complex" antigens
29. Characterization of two novel Ly-6 genes: Protein sequence and potential structural similarity to α-bungarotoxin and other neurotoxins
30. Ly-6-domain proteins: New insights and new members: A C-terminal Ly-6 domain in sperm acrosomal protein SP-10
31. The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction
32. TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes
33. Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies
34. Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on lymphoid cells
35. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion
36. Thymic-shared antigen-1 (TSA-I): A lymphostromal cell membrane Ly-6 superfamily molecule with a putative role in cellular adhesion
37. TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor
38. Inhibition of Ly-6A antigen expression prevents T cell activation
39. T cell receptor/CD3 negative variants are unresponsive to stimulation through the Ly-6 encoded molecule
40. Thy-1 and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require coexpression of the T cell antigen receptor complex
41. + T cells mature in the absence of MHC class I and II expression in Ly-6A.2 transgenic mice
42. Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice
43. Down-regulation of IL-2 production by activation of T cells through Ly-6A/E
44. A monoclonal antibody against the 66-kDa protein expressed in mouse spleen and thymus inhibits Ly-6A.2-dependent cell-cell adhesion
45. Ly6d-L, a ligand for mouse Ly6d
46. Regulation of T cell fate by Notch
47. Regulated expression of Ly-6A.2 is important for T cell development
48. 10 thymocytes in vivo
49. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody
50. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
51. MHC class II-bound self peptides from autoimmune MRL/lpr mice reveal potential T cell epitopes for autoantibody production in murine systemic lupus erythematosus
52. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice
53. 2-Microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice
54. Abnormalities induced by the mutant gene lpr: Expansion of a unique lymphocyte subset
55. 2+ indicators with greatly improved fluorescence properties
56. Selective upregulation of interferon-γ of surface molecules of the Ly-6/E complex in resting T cells: The Ly-6A/E and TAP antigens are preferentially enhanced
57. The augmentation of surface Ly-6A/E molecules in activated T cells is mediated by endogenous interferon-γ
58. Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity
59. The function of GPI-anchored proteins in T cell development, activation and regulation of homeostasis
60. + T cells provide an initial source of IL-4 during Th2 differentiation
61. + T cell responses: The alternative approaches
62. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
63. B7-2 (CD86) is essential for the development of IL-4-producing T cells
64. CD28 costimulation promotes the production of Th2 cytokines
65. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis
66. A role for CD4 in peripheral T cell differentiation
67. Impaired Th2 subset development in the absence of CD4
68. CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
69. + T cells into high IL-4-producing effectors
70. LFA-I interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production
71. Intercellular adhesion molecule-inhibits interleukin 4 production by naive T cells
72. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
73. The antigen dose determines T helper subset development by regulation of CD40 ligand
74. The role of CTLA-4 in regulating Th2 differentiation
75. Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption
76. Lynxl, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS
77. Mutations in the gene encoding SLURF-1 in Mal de Meleda