Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?

Breast Cancer Research

Volumn 4, Issue 2, 2002, Pages 54-57

  McAllister, Kimberly A ^a   Wiseman, Roger W ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Apoptosis; Brca1; Breast cancer; Trp53; Tumorigenesis

Indexed keywords

BRCA1 PROTEIN; DNA; TRANSCRIPTION FACTOR; TRP53 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; DNA REPAIR; EMBRYO; EXON; GENE DELETION; HAPLOIDY; HOMOZYGOSITY; LETHALITY; MOUSE; NONHUMAN; PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; BRCA1 PROTEIN; CELL CYCLE; FEMALE; GENES, BRCA1; GENES, LETHAL; GENES, P53; MAMMARY NEOPLASMS, ANIMAL; MICE; MUTATION;

EID: 0036127880     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr422     Document Type: Article

References (26)

1. Cancer-susceptibility genes. Gate-keepers and caretakers
2. Roles of BRCA1 and its interacting proteins
3. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle, and tumorigenesis
4. BRCA1 regulates p53-dependent gene expression
5. BRCA1 physically associates with p53 and stimulates its transcriptional activity
6. The second BRCT domain of BRCA1 protein interacts with p53 and stimulates transcription from the p21(WAF1/CIP1) promoter
7. Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents
8. Repression of BRCA1 through a feedback loop involving p53
9. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
10. TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: Distinctive spectrum and structural distribution
11. Mammary tumor formation in p53- and BRCA1-deficient mice
12. Conditional mutant of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
13. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
14. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
15. Partial rescue of Brca1(5-6) early embryonic lethality by p53 or p21 null mutation
16. Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice
17. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
18. Thymic lymphomas in mice with a truncating mutation in Brca2
19. Tumorigenesis in mice carrying a truncating Brca1 mutation
20. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
21. P53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours
22. Novel p53 mutations selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions
23. Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome
24. p53-dependent apoptosis suppresses tumor growth and progression in vivo
25. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis
26. Insights into cancer from transgenic mouse models