Progress of liquid chromatography-mass spectrometry in clinical and forensic toxicology

Therapeutic Drug Monitoring

Volumn 24, Issue 2, 2002, Pages 255-276

  Marquet, Pierre ^a  

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

Author keywords

Atmospheric pressure chemical ionization; Electrospray; General unknown screening; Liquid chromatography mass spectrometry; Therapeutic drug monitoring

Indexed keywords

AMITRIPTYLINE; AMPHETAMINE; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CANNABINOID; CARDIAC GLYCOSIDE; COCAINE; DESIPRAMINE; DOXEPIN; FLUNITRAZEPAM; ILOPERIDONE; IMIPRAMINE; LYSERGIDE; MIDAZOLAM; NEFAZODONE; NEUROLEPTIC AGENT; NORDOXEPIN; OLANZAPINE; OPIATE DERIVATIVE; OXAZEPAM; PESTICIDE; PRAMIPEXOLE; RISPERIDONE; SERTINDOLE; STEROID; TRIAZOLAM; TRIMIPRAMINE; UNINDEXED DRUG; XENOBIOTIC AGENT;

ANALYTIC METHOD; ARTICLE; ATMOSPHERIC PRESSURE; DRUG ABUSE; DRUG MONITORING; HUMAN; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SCREENING TEST; TANDEM MASS SPECTROMETRY; TOXICOLOGY;

CHROMATOGRAPHY, LIQUID; DRUG MONITORING; FORENSIC MEDICINE; HUMANS; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; TOXICOLOGY;

EID: 0036126834     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200204000-00008     Document Type: Article

References (115)

1. Applications of liquid chromatography-mass spectrometry in analytical toxicology: A review
2. Liquid chromatography-mass spectrometry in forensic and clinical toxicology
3. The role of liquid chromatography-mass spectrometry in the determination of heroin and related opioids in biologic fluids
4. Liquid chromatography-mass spectrometry: Potential in forensic and clinical toxicology
5. Liquid chromatography-mass spectrometry in forensic toxicology
6. State-of the-art in liquid chromatography-mass spectrometry
7. Electrospray interface for liquid chromatographs and mass spectrometers
8. Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry
9. Advances in instrumentation in liquid chromatography-mass spectrometry and related liquid-introduction techniques
10. Liquid ion evaporation/mass spectrometry/mass spectrometry for the determination of polar and labile molecules
11. Atmospheric pressure ionization (API) mass spectrometry. Solvent-mediated ionization of samples introduced in solution and in a liquid chromatograph effluent stream
12. High-performance liquid chromatographic-ES mass spectrometric determination of morphine and its 3- and 6-glucuronides: Application to pharmacokinetic studies
13. Determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human serum by solid-phase extraction and liquid chromatography-mass spectrometry with ES ionisation
14. Simultaneous determination of heroin, 6-monoacetylmorphine, morphine, and its glucuronides by liquid chromatography-atmospheric pressure ionspray-mass spectrometry
15. High-performance liquid chromatography-mass spectrometry analysis of morphine and morphine metabolites and its application to a pharmacokinetic study in male Sprague-Dawley rats
16. Determination of opiates and cocaine and its metabolites in biologic fluids by high-performance liquid chromatography with ES tandem mass spectrometry
17. Simultaneous assay of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma using normal-phase liquid chromatography-tandem mass spectrometry with a silica column and an aqueous organic mobile phase
18. Determination of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma after intravenous and intrathecal morphine administration using HPLC with ES ionization and tandem mass spectrometry
19. Fast screening for drugs of abuse by solid-phase extraction combined with flow-injection ionspray-tandem mass spectrometry
20. The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry
21. Determination of morphine and its 3- and 6-glucuronides, codeine-glucuronide and 6-monoacetylmorphine in body fluids by liquid chromatography atmospheric pressure chemical ionization mass spectrometry
22. Morphine, morphine-3-glucuronide, morphine-6-glucuronide and 6-monoacetylmorphine determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography in body fluids of heroin victims
23. Determination of common drugs of abuse in body fluids using one isolation procedure and liquid chromatography-atmospheric pressure chemical-ionization mass spectrometry
24. Determination of buprenorphine and norbuprenorphine in whole blood by liquid chromatography-mass spectrometry
25. HPLC/MS determination of buprenorphine and norbuprenorphine in biologic fluids and hair samples
26. Enantioselective separation of methadone and its main metabolite in human hair by liquid chromatography/ionspray-mass spectrometry
27. Identification and quantitation of despropionyl-bezitramide in postmortem samples by liquid chromatography coupled to ES ionization tandem mass spectrometry
28. Gas chromatographic-mass spectrometric analysis of alfentanil metabolites. Application to human liver microsomal alfentanil biotransformation
29. Determination of alfentanil and noralfentanil in human plasma by gas chromatography-mass spectrometry
30. Determination of subnanogram concentrations of fentanyl in plasma by gas chromatography-mass spectrometry: Comparison with standard radioimmunoassay
31. Determination of mirfentanil hydrochloride (A-3508.HCl) in human plasma by liquid chromatography-mass spectrometry
32. Narrowbore HPLC in combination with fluorescence and ES mass spectrometric detection for the analysis of cocaine and metabolites in human hair
33. Rapid confirmation/quantitation of cocaine and benzoylecgonine in urine utilizing high performance liquid chromatography and tandem mass spectrometry
34. Performance of a pentafluorophenylpropyl stationary phase for the ES ionization high-performance liquid chromatography-mass spectrometry-mass spectrometry assay of cocaine and its metabolite ecgonine methyl ester in human urine
35. Liquid chromatography-tandem mass spectrometry analysis of cocaine and its metabolite from blood, amniotic fluid, placental and fetal tissues: Study on the metabolism and distribution of cocaine in pregnant rats
36. Identification and quantitation of cocaine N-oxide: A thermally labile metabolite of cocaine
37. Direct determination of ecgonine methyl ester and cocaine in rat plasma, utilizing on-line sample extraction coupled with rapid chromatography/quadrupole orthogonal acceleration time-of-flight detection
38. Analysis of benzoylecgonine in dried blood spots by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
39. A validated stable isotope dilution liquid chromatography tandem mass spectrometry assay for the trace analysis of cocaine and its major metabolites in plasma
40. Effects of 3,4-methylenedioxymethamphetamine in decomposing tissues on the development of Parasarcophaga ruficornis (Diptera: Sarcophagidae) and detection if the drug in postmortem blood, liver tissue, larvae, and puparia
41. Direct analysis of methamphetamine and amphetamine enantiomers in human urine by semi-column HPLC-ES ionization mass spectrometry
42. Discrimination of dimethylamphetamine and methamphetamine use: Simultaneous determination of dimethylamphetamine-N-oxide and other metabolites in urine by high-performance liquid chromatography-ES ionization mass spectrometry
43. Simple and rapid determination of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by automated in-tube solid-phase microextraction coupled with liquid chromatography-ES ionization mass spectrometry
44. Investigation of the quantitative properties of the quadrupole orthogonal acceleration time-of-flight mass spectrometer with ES ionisation using 3,4-methylenedioxymethamphetamine
45. Determination of phenylisothiocyanate derivatives of amphetamine and its analogues in biologic fluids by HPLC-APCI-MS or DAD
46. Analysis of underivatized amphetamines and related phenetylamines with high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
47. Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma
48. Determination of 11-nor-delta9-tetrahydrocannabinol-9-carboxilic acid in urine using high-performance liquid chromatography and ES ionization mass spectrometry
49. Simultaneous determination of THC-COOH and THC-COOH-glucuronide in urine samples by LC/MS/MS
50. Detection of metabolites of lysergic acid diethylamide (LSD) in human urine specimens: 2-oxo-3-hydroxy-LSD, a prevalent metabolite of LSD
51. The determination of lysergide in urine by high-performance liquid chromatography combined with ES ionisation mass spectrometry
52. Determination of drugs from urine by online immunoaffinity chromatography-mass spectrometry
53. The analysis of lysergide (LSD): Development of novel enzyme immunoassay and immunoaffinity extraction procedures together with an HPLC-MS confirmation procedure
54. The determination of lysergide (LSD) in urine by high performance liquid chromatography-isotope dilution mass spectrometry (IDMS)
55. Determination of LSD and N-demethyl-LSD in urine by liquid chromatography coupled to ES ionization mass spectrometry
56. Dosage du LSD et de trois de ses métabolites ou isomères dans le sérum et le sang total par LC-ES-MS
57. Automated extraction of lysergic acid diethylamide (LSD) and N-demethyl-LSD from blood, serum, plasma and urine samples using the RapidTrace™ with LC/MS/MS confirmation
58. Elucidation of LSD in vitro metabolism by liquid chromatography and capillary electrophoresis with tandem mass spectrometry
59. On-line immunoaffinity extraction-coupled column capillary liquid chromatography/tandem mass spectrometry: Trace analysis of LSD analogs and metabolites in human urine
60. Atmospheric pressure ion-sampling system for liquid chromatography/mass spectrometry analyses on a benchtop mass spectrometer
61. Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography-mass spectrometry
62. Sensitive and specific determination of midazolam and 1-hydroxymidazolam in human serum by liquid chromatography-ES mass spectrometry
63. A highly sensitive method to quantify triazolam and its metabolites with liquid chromatography-mass spectrometry
64. Determination of oxazepam glucuronide in human urine by liquid chromatography/APCI-mass spectrometry
65. Determination of flunitrazepam and its metabolites in blood by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
66. High-performance liquid chromatography-mass spectrometry for the quantification of nortriptyline and 10-hydroxynortriptyline in plasma
67. Sensitive liquid chromatographic-mass spectrometric assay for the simultaneous quantitation of nefazodone and its metabolites hydroxynefazodone m-chlorophenylpiperazine and triazole-dione in human plasma using single-ion monitoring
68. Determination of doxepin and desmethyldoxepin in human plasma using liquid chromatography-tandem mass spectrometry
69. Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma
70. Determination of haloperidol and its reduced metabolite in human plasma by liquid chromatography-mass spectrometry with ES ionization
71. Determination of olanzapine in human plasma and serum by liquid chromatography/tandem mass spectrometry
72. Simultaneous determination of risperidone and 9-hydroxyrisperidone in plasma by liquid chromatography/ES tandem mass spectrometry
73. Determination of trimeprazine and its main metabolites in mouse serum and thyroid by liquid chromatography-ES-mass spectrometry
74. Electrospray ionisation-mass spectrometry characterisation of selected anti-psychotic drugs and their detection and determination in human hair samples by liquid chromatography-tandem mass spectrometry
75. Determination of phenothiazines in human body fluids by solid-phase microextraction and liquid chromatography/tandem mass spectrometry
76. High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma
77. A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-ES-mass spectrometry
78. Comparative LC-MS and HPLC analyses of selected antiepileptics and beta-blocking drugs
79. Enantiospecific determination of nimodipine in human plasma by liquid chromatography-tandem mass spectrometry
80. Simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry
81. Sensitive and selective liquid chromatographic-tandem mass spectrometric assay for barnidipine in human plasma
82. Direct determination of anabolic steroid conjugates in human urine by combined high-performance liquid chromatography and tandem mass spectrometry
83. Direct measurement of steroid sulfate and glucuronide conjugates with high-performance liquid chromatography-mass spectrometry
84. Electrospray and atmospheric pressure chemical ionization tandem mass spectrometric behavior of eight anabolic steroid glucuronides
85. Bioanalysis of beta-2-agonists by hyphenated chromatographic and mass spectrometric techniques
86. Determination of β-agonist residues in human plasma using LC-APCI/MS
87. Gas and liquid chromatography coupled to tandem mass spectrometry for the multiresidue analysis of beta-agonists in biologic matrices
88. Quantitative multi-residue determination of beta-agonists in bovine urine using on-line immunoaffinity extraction-coupled column packed capillary liquid chromatography-tandem mass spectrometry
89. LC-MS-MS to detect and identify four beta-agonists and quantify clenbuterol in liver
90. An evaluation of atmospheric pressure ionization techniques for the analysis of N-methyl carbamate pesticides by liquid chromatography mass spectrometry
91. Simple, rapid and simultaneous measurement of eight different types of carbamate pesticides in serum using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
92. Application of liquid chromatography-atmospheric-pressure-chemical-ionization mass spectrometry to pesticide analysis
93. Identification of a major human urinary metabolite of alachlor by LC-MS/MS
94. Identification of a major human urinary metabolite of metolachlor by LC-MS/MS
95. Direct determination of chlorpyrifos and its main metabolite 3,5,6-trichloro-2-pyridinol in human serum and urine by coupled-column liquid chromatography/ES-tandem mass spectrometry
96. Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS and LC-ESI-MS-MS
97. Sensitive and specific multiresidue methods for the determination of pesticides of various classes in clinical and forensic toxicology
98. LC/MS with a particle beam interface in forensic toxicology
99. Screening for drugs in serum and urine by LC/ESI/CID-MS and MS/MS with library searching
100. Identification of lorazepam and sildenafil as examples for the application of LC/ionspray-MS and MS-MS with mass spectra library searching in forensic toxicology
101. Automated liquid chromatographic/tandem mass spectrometric method for screening beta-blocking drugs in urine
102. A library of atmospheric pressure ionization daughter ion mass spectra based on wideband excitation in an ion trap mass spectrometer
103. Evaluation of automated single mass spectrometry to tandem mass spectrometry function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer
104. Broad spectrum drug identification directly from urine, using liquid chromatography-tandem mass spectrometry
105. "General unknown" screening of xenobiotics in serum by LC-ES-MS
106. In-source CID mass spectral libraries for the "general unknown" screening of drugs and toxicants
107. Screening for drugs in serum by ES ionization/collision-induced dissociation and library searching
108. Poor reproducibility of in-source collisional atmospheric pressure ionization mass spectra in toxicologically relevant drugs
109. Application of spectral libraries for high performance liquid chromatography-atmospheric pressure ionisation mass spectrometry to the analysis of pesticide and explosve residues in environmental samples
110. Comparison of softwares used for the detection of analytes present at low levels in liquid chromatographic-mass spectrometric experiments
111. Identification of selected psychopharmaceuticals and their metabolites in hair by LC/ESI-CID/MS and LC/MS/MS
112. Evaluation of ES transport CID for the generation of searchable libraries