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Volumn 20, Issue 1, 1996, Pages 27-37

Elucidation of LSD in vitro metabolism by liquid chromatography and capillary electrophoresis coupled with tandem mass spectrometry*

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; ERGOMETRINE; LYSERGIC ACID; LYSERGIDE; METHYSERGIDE;

EID: 0030025130     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/20.1.27     Document Type: Article
Times cited : (65)

References (33)
  • 2
    • 0017342110 scopus 로고
    • LSD toxicity: A suspected cause of death
    • E.A. Griggs and M. Ward. LSD toxicity: a suspected cause of death. J. Ky. Med. Assoc. 75: 172-73 (1977).
    • (1977) J. Ky. Med. Assoc. , vol.75 , pp. 172-173
    • Griggs, E.A.1    Ward, M.2
  • 3
    • 0000489805 scopus 로고
    • Drug addiction and drug abuse
    • A.C. Goodman, T.W. Rail, A.S. Nies, and P. Taylor, Eds., Pergamon Press, New York, NY
    • J.H. Jaffe. Drug addiction and drug abuse. In The Pharmacological Basis of Therapeutics, 8th ed. A.C. Goodman, T.W. Rail, A.S. Nies, and P. Taylor, Eds., Pergamon Press, New York, NY, 1990, pp 523-73.
    • (1990) The Pharmacological Basis of Therapeutics, 8th Ed. , pp. 523-573
    • Jaffe, J.H.1
  • 5
    • 0025183663 scopus 로고
    • Determination of lysergic acid diethylamide (LSD) in urine by instrumental high-performance thin-layer chromatography
    • L.M. Blum, E.F. Carenzo, and F. Rieders. Determination of lysergic acid diethylamide (LSD) in urine by instrumental high-performance thin-layer chromatography. J. Anal. Toxicol. 14: 285-87 (1990).
    • (1990) J. Anal. Toxicol. , vol.14 , pp. 285-287
    • Blum, L.M.1    Carenzo, E.F.2    Rieders, F.3
  • 6
    • 0019128987 scopus 로고
    • Analysis of LSD in urine using radioimmunoassay-excretion and storage effects
    • H.W. Peel and A.L. Boynton. Analysis of LSD in urine using radioimmunoassay-excretion and storage effects. Can. Soc, Forensic Sci. J. 13: 23-28 (1980).
    • (1980) Can. Soc, Forensic Sci. J. , vol.13 , pp. 23-28
    • Peel, H.W.1    Boynton, A.L.2
  • 7
    • 0025354535 scopus 로고
    • Confirmation of LSD intoxication by analysis of serum and urine
    • M.M. McCarron, C.B. Walberg, and R.C. Baselt. Confirmation of LSD intoxication by analysis of serum and urine. J. Anal. Toxicol. 14: 165-67 (1990).
    • (1990) J. Anal. Toxicol. , vol.14 , pp. 165-167
    • McCarron, M.M.1    Walberg, C.B.2    Baselt, R.C.3
  • 8
    • 0026705134 scopus 로고
    • Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry
    • C.C. Nelson and R.L. Foltz. Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry. Anal. Chem. 64: 1578-85 (1992).
    • (1992) Anal. Chem. , vol.64 , pp. 1578-1585
    • Nelson, C.C.1    Foltz, R.L.2
  • 10
    • 0001256464 scopus 로고
    • Lysergic acid diethylamide (LSD)
    • R.C. Baselt, Ed., Year Book Medical Publishers, Chicago, IL
    • R.B. Foltz and R.L. Foltz. Lysergic acid diethylamide (LSD). In Advances in Analytical Toxicology, Vol. 2. R.C. Baselt, Ed., Year Book Medical Publishers, Chicago, IL, 1989, pp 140-58.
    • (1989) Advances in Analytical Toxicology , vol.2 , pp. 140-158
    • Foltz, R.B.1    Foltz, R.L.2
  • 11
    • 0026703340 scopus 로고
    • Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids
    • C.C. Nelson and R.L. Foltz. Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids. J. Chromatogr. 580:97-109 (1992).
    • (1992) J. Chromatogr. , vol.580 , pp. 97-109
    • Nelson, C.C.1    Foltz, R.L.2
  • 12
    • 3342965740 scopus 로고
    • Salt Lake City, UT, personal communication
    • R.L. Foltz. Northwest Toxicology, Salt Lake City, UT, personal communication, 1994.
    • (1994) Northwest Toxicology
    • Foltz, R.L.1
  • 13
    • 0002523133 scopus 로고
    • Atmospheric pressure ionsampling system for liquid chromatography/mass spectrometry analysis on a benchtop mass spectrometer
    • K.L. Duffin, T. Wachs, and J. Henion. Atmospheric pressure ionsampling system for liquid chromatography/mass spectrometry analysis on a benchtop mass spectrometer. Anal. Chem. 64: 61-68 (1992).
    • (1992) Anal. Chem. , vol.64 , pp. 61-68
    • Duffin, K.L.1    Wachs, T.2    Henion, J.3
  • 14
    • 0025125769 scopus 로고
    • High-performance liquid chromatography/tandem mass spectrometry: Its use for the identification of stanazolol and its major metabolites in human and equine urine
    • W.M. Muck and J.D. Henion. High-performance liquid chromatography/tandem mass spectrometry: its use for the identification of stanazolol and its major metabolites in human and equine urine. Biomed. Environ. Mass Spectrom. 19: 37-51 (1990).
    • (1990) Biomed. Environ. Mass Spectrom. , vol.19 , pp. 37-51
    • Muck, W.M.1    Henion, J.D.2
  • 15
    • 0027994563 scopus 로고
    • Quantitative capillary electrophoresis-ion spray mass spectrometry on a benchtop ion trap for the determination of isoquinoline alkaloids
    • J. Henion, A. Mordehai, and J. Cai. Quantitative capillary electrophoresis-ion spray mass spectrometry on a benchtop ion trap for the determination of isoquinoline alkaloids. Anal. Chem. 66: 2103-2109 (1994).
    • (1994) Anal. Chem. , vol.66 , pp. 2103-2109
    • Henion, J.1    Mordehai, A.2    Cai, J.3
  • 16
    • 0027485730 scopus 로고
    • Investigation of the metabolic fate of the neuroleptic drug haloperidol by capillary electrophoresis-electrospray ionization mass spectrometry
    • A.J. Tomlinson, L.M. Benson, K.L. Johnson, and S. Naylor. Investigation of the metabolic fate of the neuroleptic drug haloperidol by capillary electrophoresis-electrospray ionization mass spectrometry. J. Chromatogr. 621: 239-48 (1993).
    • (1993) J. Chromatogr. , vol.621 , pp. 239-248
    • Tomlinson, A.J.1    Benson, L.M.2    Johnson, K.L.3    Naylor, S.4
  • 17
    • 0023762830 scopus 로고
    • Quantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometry
    • H.K. Lim, D. Andrenyak, P. Francom, R.T. Jones, and R.L. Foltz. Quantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometry. Anal. Chem. 60: 1420-25 (1988).
    • (1988) Anal. Chem. , vol.60 , pp. 1420-1425
    • Lim, H.K.1    Andrenyak, D.2    Francom, P.3    Jones, R.T.4    Foltz, R.L.5
  • 18
    • 0007972566 scopus 로고
    • The distribution and metabolism of lysergic acid diethylamide
    • J. Axelrod, R.O. Brady, B. Witkop, and E.V. Evarts. The distribution and metabolism of lysergic acid diethylamide. Ann. N.Y. Acad. Sci. 66: 435-44 (1957).
    • (1957) Ann. N.Y. Acad. Sci. , vol.66 , pp. 435-444
    • Axelrod, J.1    Brady, R.O.2    Witkop, B.3    Evarts, E.V.4
  • 19
    • 0027167823 scopus 로고
    • Capillary electrophoresis/mass spectrometry detection of inorganic ions using ion spray-sheath flow interface
    • T.C. Huggins and J.D. Henion. Capillary electrophoresis/mass spectrometry detection of inorganic ions using ion spray-sheath flow interface. Electrophoresis 14: 531-39 (1993).
    • (1993) Electrophoresis , vol.14 , pp. 531-539
    • Huggins, T.C.1    Henion, J.D.2
  • 21
    • 0018813764 scopus 로고
    • Studies on lysergic acid diethylamide and related compounds. Part 8. Structural identification of new metabolites of lysergic acid diethylamide obtained by microbial transformation using Streptomyces roseochromogenes
    • H. Ishii, T. Niwaguchi, Y. Nakahara, and M. Hayashi. Studies on lysergic acid diethylamide and related compounds. Part 8. Structural identification of new metabolites of lysergic acid diethylamide obtained by microbial transformation using Streptomyces roseochromogenes. J. Chem. Soc., Perkin Trans. 1: 902-905 (1980).
    • (1980) J. Chem. Soc., Perkin Trans. , vol.1 , pp. 902-905
    • Ishii, H.1    Niwaguchi, T.2    Nakahara, Y.3    Hayashi, M.4
  • 23
    • 0018220153 scopus 로고
    • Mass spectroscopy of natural products III - Mass spectrometric comparison of lysergic acid and 9,10-dihydrolysergic acid
    • J. Schmidt, R. Kraft, and D. Voigt. Mass spectroscopy of natural products III - mass spectrometric comparison of lysergic acid and 9,10-dihydrolysergic acid. Biomed. Mass Spectrom. 5: 674-78 (1978).
    • (1978) Biomed. Mass Spectrom. , vol.5 , pp. 674-678
    • Schmidt, J.1    Kraft, R.2    Voigt, D.3
  • 24
    • 0013851092 scopus 로고
    • High resolution mass spectroscopy of the clavine and ergot-peptide alkaloids
    • M. Barber, J.A. Weisbach, B. Douglas, and G.O. Dudek. High resolution mass spectroscopy of the clavine and ergot-peptide alkaloids. Chem. Ind. 19: 1072-73 (1965).
    • (1965) Chem. Ind. , vol.19 , pp. 1072-1073
    • Barber, M.1    Weisbach, J.A.2    Douglas, B.3    Dudek, G.O.4
  • 25
    • 0011237942 scopus 로고
    • 'Metabolic mapping' of drugs: Rapid screening for polar metabolites using FAB MS/MS
    • S.J. Gaskell, Ed., Wiley, Sussex, England
    • K.M. Straub. 'Metabolic mapping' of drugs: rapid screening for polar metabolites using FAB MS/MS. In Mass Spectrometry in Biomedical Research. S.J. Gaskell, Ed., Wiley, Sussex, England, 1986, pp 115-34.
    • (1986) Mass Spectrometry in Biomedical Research , pp. 115-134
    • Straub, K.M.1
  • 26
    • 0026939415 scopus 로고
    • Utility of the parent-neutral loss scan screening technique: Partial characterization of urinary metabolites of U-78875 in monkey urine
    • J.J. Vrbanac, I.A. O'Leary, and L. Baczynskyj. Utility of the parent-neutral loss scan screening technique: partial characterization of urinary metabolites of U-78875 in monkey urine. Biol. Mass Spectrom. 21: 517-22 (1992).
    • (1992) Biol. Mass Spectrom. , vol.21 , pp. 517-522
    • Vrbanac, J.J.1    O'Leary, I.A.2    Baczynskyj, L.3
  • 27
    • 0023858064 scopus 로고
    • Rapid identification of drug metabolites with tandem mass spectrometry
    • M.S. Lee and Y.A. Yost. Rapid identification of drug metabolites with tandem mass spectrometry. Biomed. Environ. Mass Spectrom. 15:193-204 (1988).
    • (1988) Biomed. Environ. Mass Spectrom. , vol.15 , pp. 193-204
    • Lee, M.S.1    Yost, Y.A.2
  • 29
    • 0027407476 scopus 로고
    • High-flow ion spray liquid chromatography/mass spectrometry
    • G. Hopfgartner, T. Wachs, K. Bean, and J. Henion. High-flow ion spray liquid chromatography/mass spectrometry. Anal. Chem. 65: 439-46 (1993).
    • (1993) Anal. Chem. , vol.65 , pp. 439-446
    • Hopfgartner, G.1    Wachs, T.2    Bean, K.3    Henion, J.4
  • 30
    • 0015984577 scopus 로고
    • Studies on enzymatic dealkyiation of d-lysergic acid diethylamide (LSD)
    • T. Niwaguchi, T. Inoue, and Y. Nakahara. Studies on enzymatic dealkyiation of d-lysergic acid diethylamide (LSD). Biochem. Pharmacol. 23: 1073-78 (1974).
    • (1974) Biochem. Pharmacol. , vol.23 , pp. 1073-1078
    • Niwaguchi, T.1    Inoue, T.2    Nakahara, Y.3
  • 32
    • 0018646245 scopus 로고
    • Studies on lysergic acid diethylamide and related compounds. VII. Microbial transformation of lysergic acid diethylamide and related compounds
    • H. Ishii, M. Hayashi, T. Niwaguchi, and Y. Nakahara. Studies on lysergic acid diethylamide and related compounds. VII. Microbial transformation of lysergic acid diethylamide and related compounds. Chem. Pharm. Bull. 27: 1570-75 (1979).
    • (1979) Chem. Pharm. Bull. , vol.27 , pp. 1570-1575
    • Ishii, H.1    Hayashi, M.2    Niwaguchi, T.3    Nakahara, Y.4
  • 33
    • 3342965741 scopus 로고
    • The hallucinogenic drugs
    • M. Calvin and M.J. Jorgenson, Eds., W.H. Freeman and Co., San Francisco, CA
    • F. Barron, M.E. Jarvik, and S.B.J. Bunnel. The hallucinogenic drugs. In Bio-organic Chemistry. M. Calvin and M.J. Jorgenson, Eds., W.H. Freeman and Co., San Francisco, CA, 1968, pp 179-92.
    • (1968) Bio-organic Chemistry , pp. 179-192
    • Barron, F.1    Jarvik, M.E.2    Bunnel, S.B.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.