Determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human serum by solid-phase extraction and liquid chromatography-mass spectrometry with electrospray ionisation

Journal of Chromatography A

Volumn 729, Issue 1-2, 1996, Pages 279-285

  Tyrefors, Niklas ^a,c   Hyllbrant, Benita ^b   Ekman, Lena ^a   Johansson, Monika ^a   Långström, Bengt ^c  

^a PMC Contract Research AB   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Glucuronide; Liquid chromatography mass spectrometry; Morphine; Morphine glucuronide

Indexed keywords

DRUG METABOLITE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ACCURACY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SOLID PHASE EXTRACTION; TECHNIQUE;

EID: 0029966451     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9673(95)01090-4     Document Type: Conference Paper

References (19)

1. U. Boerner, S. Abbott and R.L. Rose, Drug Metab. Rev., 4 (1975) 39.
2. S.Y. Yeh, J. Pharmacol. Exp. Ther., 192 (1975) 201.
3. U. Boerner, R.L. Roe and C.E. Becker, J. Pharm. Pharmacol., 26 (1974) 393.
4. J. Hasselström and J. Säwe, Clin. Pharmacokinet., 24 (1993) 344.
5. S. Spector and C.W. Parker, Science, 168 (1970) 1347.
6. G.W. Aherne, in J.F.B. Stuart (Editor), Methods of Morphine Estimation in Biological Fluids and the Concept of Free Morphine, Royal Society of Medicine, London, 1983, p. 21.
7. B. Dahlström and L. Paalzow, J. Pharm. Pharmacol., 27 (1975) 172.
8. P.O. Edlund, J. Chromatogr., 206 (1981) 109.
9. M.W. White, J. Chromatogr., 178 (1979) 229.
10. J.-O. Svensson, A. Rane, J. Säwe and F. Sjöqvist, J. Chromatogr., 230 (1982) 427.
11. J.-O. Svensson, J. Chromatogr., 375 (1986) 174.
12. P.P. Rop, F. Grimaldi, J. Burle, M.N. De Saint Leger and A. Viala, J. Chromatogr. B, 661 (1994) 245.
13. A.W.E. Wright, J.A. Watt, M. Kennedy, T. Cramond and M.T. Smith, Ther. Drug Monit., 16 (1994) 200.
14. F. Tagliaro, D. Franchi, R. Dorizzi and M. Marigo, J. Chromatogr., 488 (1989) 215.
15. P.A. Glare, T.D. Walsh and C.E. Pippenger, Ther. Drug Monit., 13 (1991) 226.
16. J. Papadoyannis, A. Zotou, V. Samanidou, G. Theodoridis and F. Zougrou, J. Liq. Chromatogr., 16 (1993) 3107.
17. E.C. Hung, T. Wachs, J.J. Conboy and J.D. Henion, Anal. Chem., 62 (1990) 713A.
18. Papadoyannis, A. Zotou, V. Samanidou, G. Theodoridis and F. Zougrou, J. Liq. Chromatogr., 16 (1993) 3107.
19. M. Pawula, D.A. Barrett and P.N. Shaw, J. Pharm. Biomed. Anal., 11 (1993) 401.