Fast screening for drugs of abuse by solid-phase extraction combined with flow-injection ionspray-tandem mass spectrometry

Journal of Analytical Toxicology

Volumn 22, Issue 4, 1998, Pages 319-328

  Weinmann, Wolfgang ^a   Svoboda, Michal ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b European Life Science Center   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; BENZOYLECGONINE; COCAINE; CODEINE; DIHYDROCODEINE; ECGONINE METHYL ESTER; HYDROCODONE; HYDROMORPHONE; ILLICIT DRUG; METHAMPHETAMINE; MORPHINE; MORPHINE 6 ACETATE;

ANALYTIC METHOD; ARTICLE; BLOOD LEVEL; DEVICE; DRUG ABUSE; DRUG SCREENING; FLOW INJECTION ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINE LEVEL;

EID: 0031829181     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/22.4.319     Document Type: Article

References (26)

1. J.B. Fenn, M. Mann, C.K. Meng, S.F. Wong, and C.M. Whitehouse. Electrospray ionization for mass spectrometry of large biomolecules. Science 246: 64-71 (1989).
2. P. Kebarle and T. Liang. From ions in solution to ions in gas phase-the mechanism of electrospray mass spectrometry. Anal. Chem. 65: A972-A986 (1993).
3. B. Kaye, M.W. Clark, N.J. Cussans, P.V. Macrae, and D.A. Stopher. The sensitive determination of abanoquil in blood by high-performance liquid chromatography/atmospheric pressure ionization mass spectrometry. Biol. Mass Spectrom. 21: 585-589 (1992).
4. P. Picotte, G. Sanchez, B. Shushan, and T. Sakuma. HPLC/ion-spray/MSMS analysis of common and illicit drugs in case samples. Proceedings of the 43rd Conference on Mass Spectrometry and Allied Topics (ASMS), American Society for Mass Spectrometry, Santa Fe, NM, 1995, p 517.
5. B. Casetta and F. Garofolo. Characterization of explosives by liquid chromatography mass spectrometry and liquid chromatography tandem mass spectrometry using electrospray ionization and parent ion scanning techniques. Org. Mass Spectrom. 29: 517-525 (1994).
6. D. Volmer and K. Levsen. Mass spectrometric analysis of nitrogen-containing and phosphorus-containing pesticides by liquid chromatography mass spectrometry. J. Am. Soc. Mass Spectrom. 5: 655-675 (1994).
7. G. Rule, L.G. McLaughlin, and J. Henion. A quest for oleandrin in decayed human tissue. Anal. Chem. 65: A857-A863 (1993).
8. M. Svoboda, W. Meister, and W. Vetter. A method for counting disulfide bridges in small proteins by reduction with mercaptoethanol and electrospray mass spectrometry. J. Mass Spectrom. 30: 1562-1566 (1995).
9. M. Przybylski and M.O. Glocker. Electrospray mass spectrometry of biomacromolecular complexes with noncovalent interactions - new analytical perspectives for supramolecular chemistry and molecular recognition processes. Angew. Chem. Int. Ed. Engl. 35: 806-626 (1996).
10. S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler, and F.W. McLafferty. Fourier-tranform electrospray instrumentation for tandem high-resolution mass spectrometry of large molecules. J. Am. Soc. Mass Spectrom. 7: 557-565 (1993).
11. C.E. Parker, J.R. Perkins, K.B. Tomer, Y. Shida, K. O'Hara, and M. Kono. Application of nanoscale packed capillary liquid chromatography (75 μm id) and capillary zone electrophoresis/electrospray ionization mass spectrometry to the analysis of macrolide antibiotics. J. Am. Soc. Mass Spectrom. 3: 563-574 (1992).
12. 252Cf plasma desorption and electrospray mass spectrometry for the structural characterization of hydrophobic polypeptides using organic solvents. Electrophoresis 15: 228-233 (1994).
13. J. Cai and J. Henion. Elucidation of LSD in vitro metabolism by liquid chromatography and capillary electrophoresis coupled with tandem mass spectrometry. J. Anal. Toxicol. 20: 27-37 (1996).
14. F.W. McLafferty. Tandem Mass Spectrometry. Wiley, New York, NY, 1983.
15. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and their Metabolites. Verlag Chemie, Weinheim, Germany, 1992, pp 5-32.
16. R.L. Foltz. Recent applications of mass spectrometry in forensic toxicology. Int. J. Mass Spectrom. Ion Processes 118/119: 237-263 (1992).
17. 6-monoacetylmorphine in urine samples by GC/MS as evidence for heroin use. J. Anal. Toxicol. 9: 134-138 (1985).
18. M.R. Moeller. Drug detection in hair by chromatographic procedures. J. Chromatogr. 580: 125-134 (1992).
19. M.R. Moeller, P. Fey, and R. Wennig. Simultaneous determination of drugs of abuse (opiates, cocaine and amphetamine) in human hair by GC/MS and its application to a methadone treatment program. Forensic Sci. Int. 63: 185-206 (1993).
20. W. Weinmann and M. Bohnert. Lethal monointoxication by over-dosage of MDEA. Forensic Sci. Int. 91: 91-101 (1998).
21. C.C. Nelson, M.D. Fraser, J.K. Wilfahrt, and R.L. Foltz. Gas chromatography/tandem mass spectrometry measurement of delta 9-tetrahydrocannabinol, naltrexone, and their active metabolites in plasma. Ther. Drug Monit. 15: 557-562 (1993).
22. C.C. Nelson and R.L. Foltz. Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry. Anal. Chem. 64: 1578-1585 (1992).
23. U. Hofmann, M.F. Fromm, S. Johnson, and G. Mikus. Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography tandem mass spectrometry. J. Chromatogr. Biomed. Appl. 663: 59-65 (1995).
24. Mass Spectrometry/Mass Spectrometry: Techniques and Applications of Tandem Mass Spectrometry. K.L. Busch, G.L. Glish, and S.A. McLuckey, Eds. Verlag Chemie, Weinheim, Germany, 1988, p 153.
25. W. Weinmann and C. Bohn. Quantitation of drugs of abuse by SPE and GC/MS using microliter-amounts of serum. Proceedings of the 44th Conference on Mass Spectrometry and Allied Topics (ASMS), American Society for Mass Spectrometry, Santa Fe, NM, 1996, p 977.
26. S. Vogt, M. Renz, R. Rickli, Th. Briellmann, and W. Weinmann. Automatische Festphasenextraktion zum Nachweis von Drogen und Psychopharmaka aus Blutserum und Vollblut. Toxichem. + Krimtech. 64: 96-101 (1997).