Enantioselective separation of methadone and its main metabolite in human hair by liquid chromatography/ion spray-mass spectrometry

Journal of Forensic Sciences

Volumn 42, Issue 2, 1997, Pages 291-295

  Kintz, Pascal ^a   Eser, Hans Peter ^b   Tracqui, Antoine ^a   Moeller, Manfred ^b   Cirimele, Vincent ^a   Mangin, Patrice ^a  

^a INSTITUT DE MÉDECINE LÉGALE   (France)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

chiral separation; forensic science; forensic toxicology; gas chromatography mass spectrometry; hair; methadone

Indexed keywords

2 ETHYL 1,5 DIMETHYL 3,3 DIPHENYLPYRROLINIUM; DRUG METABOLITE; METHADONE; OROSOMUCOID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; ENANTIOMER; HAIR ANALYSIS; HEROIN DEPENDENCE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; RACEMIC MIXTURE;

EID: 0031041810     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs14113j     Document Type: Article

References (17)

1. Meresaar U, Nilsson MI, Holmstrand J, Anggard E. Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotrope method. Eur J Clin Pharmacol 1981;20:473-8.
2. Säwe J, Hansen J, Ginman C, Hartvig P, Jakobsson PA, Nilson MI, et al. Patient-controlled dose regimen of methadone for chronic cancer pain. Br Med J 1981;7:771-3.
3. Judson BA, Horns WH, Goldstein A. Side effects of levomethadone and racemic methadone in a maintenance program. Clin Pharmacol Ther 1976;20:445-9.
4. Käferstein H, Staak M. Quantitative determination in a substitution programme with levomethadone. In: Mangin P, Ludes B, editors. Acta Medicinae Legalis, Berlin: 1995;507-10.
5. Brewer C. Hair analysis as a tool for monitoring and managing patients on methadone maintenance. A discussion. Forensic Sci Int 1993;63:277-83.
6. Kintz P. Forensic hair examination: Detection of drugs. In: Wecht C, editor, Forensic sciences New York: Matthew Bender: 1993;37D:1-32.
7. Baumgartner WA, Hill VA, Bear JD, Lyon IW, Charuvastra VC, Sramek JJ, et al. Detection of drug use by analysis of hair. J Nuclear Med 1988;29:980-6.
8. Balabanova S, Wolf HU. Determination of methadone in human hair by radioimmunoassay. Z Rechtsmed 1989;102:1-4.
9. Balabanova S, Arnold PJ, Brunner H, Luckow V, Wolf HU. Detection of methadone in human hair by gas chromatography/mass spectrometry. Z Rechtsmed 1989;102:495-501.
10. Moeller MR, Fey P, Wennig R. Simultaneous determination of drugs of abuse (opiates, cocaine, and amphetamine) in human hair by GC/MS and its application to a methadone treatment program. Forensic Sci Int 1993;63:185-206.
11. Goldberger BA, Darraj AG, Caplan YH, Cone FJ. Detection of methadone, methadone metabolites, and other illicit drugs of abuse in hair of methadone treatment subjects. Proceedings of the 2nd International Meeting on Clinical and Forensic Aspects of Hair Analysis; June 6-8, 1994, Geneva, Italy.
12. Kintz P, Moeller MR, Berthault F, Tracqui A, Eser HP, Mangin P. Separation of mediadone enantiomers in human urine and hair, Proceeding of the 48th Annual Meeting of the American Academy of Forensic Sciences, Feb. 19-24, 1996, Nashville, USA.
13. Beck O, Boreus LO, Lafolie P, Jacodsson G. Chiral analysis of methadone in plasma by high-performance liquid chromatography. J Chromatogr Biomed Appl 1991;570:198-202.
14. Kristensen K, Angelo HR. Stereospecific gas chromatographic method for determination of methadone in serum. Chirality 1992;4:263-7.
15. Kristensen K, Angelo HR, Blemmer T. Enantioselective high-performance liquid chromatographic method for the determination of methadone in serum using an AGP and CN column as chiral and analytical column, respectively. J Chromatogr 1994;666:283-7.
16. Kidwell DA, Blank DL. Environmental exposure - the stumbling block of hair testing. In: Kintz P, editor. Drug testing in hair, Boca Raton: CRC Press, 1996;17-68.
17. Henderson GL, Wilson BK. Excretion of methadone and metabolites in human sweat. Res Com Chem Pathol Pharmacol 1973;5:1-8.